Amide proton transfer (APT) magnetic resonance imaging of prostate cancer: comparison with Gleason scores

Yukihisa Takayama, Akihiro Nishie, Masaaki Sugimoto, Osamu Togao, Yoshiki Asayama, Kousei Ishigami, Yasuhiro Ushijima, Daisuke Okamoto, Nobuhiro Fujita, Akira Yokomizo, Jochen Keupp, Hiroshi Honda

Research output: Contribution to journalArticle

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Abstract

Objective: To evaluate the utility of amide proton transfer (APT) imaging in estimating the Gleason score (GS) of prostate cancer (Pca). Materials and methods: Sixty-six biopsy-proven cancers were categorized into four groups according to the GS: GS-6 (3 + 3); GS-7 (3 + 4/4 + 3); GS-8 (4 + 4) and GS-9 (4 + 5/5 + 4). APT signal intensities (APT SIs) and apparent diffusion coefficient (ADC) values of each GS group were compared by one-way analysis of variance with Tukey’s HSD post hoc test. Results: The mean and standard deviation of the APT SIs (%) and ADC values (×10−3 mm2/s) were as follows: GS-6, 2.48 ± 0.59 and 1.16 ± 0.26; GS-7, 5.17 ± 0.66 and 0.92 ± 0.18; GS-8, 2.56 ± 0.85 and 0.86 ± 0.17; GS-9, 1.96 ± 0.75 and 0.85 ± 0.18, respectively. The APT SI of the GS-7 group was highest, and there were significant differences between the GS-6 and GS-7 groups and the GS-7 and GS-9 groups (p < 0.05). The ADC value of the GS-6 group was significantly higher than each value of the GS-7, GS-8, and GS-9 groups (p < 0.05), but no significant differences were obtained among the GS-7, GS-8, and GS-9 groups. Conclusion: The mean APT SI in Pca with a GS of 7 was higher than that for the other GS groups.

Original languageEnglish
Pages (from-to)671-679
Number of pages9
JournalMagnetic Resonance Materials in Physics, Biology and Medicine
Volume29
Issue number4
DOIs
Publication statusPublished - Aug 1 2016

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Neoplasm Grading
Amides
Protons
Prostatic Neoplasms
Magnetic Resonance Imaging

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging

Cite this

Amide proton transfer (APT) magnetic resonance imaging of prostate cancer : comparison with Gleason scores. / Takayama, Yukihisa; Nishie, Akihiro; Sugimoto, Masaaki; Togao, Osamu; Asayama, Yoshiki; Ishigami, Kousei; Ushijima, Yasuhiro; Okamoto, Daisuke; Fujita, Nobuhiro; Yokomizo, Akira; Keupp, Jochen; Honda, Hiroshi.

In: Magnetic Resonance Materials in Physics, Biology and Medicine, Vol. 29, No. 4, 01.08.2016, p. 671-679.

Research output: Contribution to journalArticle

Takayama, Yukihisa ; Nishie, Akihiro ; Sugimoto, Masaaki ; Togao, Osamu ; Asayama, Yoshiki ; Ishigami, Kousei ; Ushijima, Yasuhiro ; Okamoto, Daisuke ; Fujita, Nobuhiro ; Yokomizo, Akira ; Keupp, Jochen ; Honda, Hiroshi. / Amide proton transfer (APT) magnetic resonance imaging of prostate cancer : comparison with Gleason scores. In: Magnetic Resonance Materials in Physics, Biology and Medicine. 2016 ; Vol. 29, No. 4. pp. 671-679.
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abstract = "Objective: To evaluate the utility of amide proton transfer (APT) imaging in estimating the Gleason score (GS) of prostate cancer (Pca). Materials and methods: Sixty-six biopsy-proven cancers were categorized into four groups according to the GS: GS-6 (3 + 3); GS-7 (3 + 4/4 + 3); GS-8 (4 + 4) and GS-9 (4 + 5/5 + 4). APT signal intensities (APT SIs) and apparent diffusion coefficient (ADC) values of each GS group were compared by one-way analysis of variance with Tukey’s HSD post hoc test. Results: The mean and standard deviation of the APT SIs ({\%}) and ADC values (×10−3 mm2/s) were as follows: GS-6, 2.48 ± 0.59 and 1.16 ± 0.26; GS-7, 5.17 ± 0.66 and 0.92 ± 0.18; GS-8, 2.56 ± 0.85 and 0.86 ± 0.17; GS-9, 1.96 ± 0.75 and 0.85 ± 0.18, respectively. The APT SI of the GS-7 group was highest, and there were significant differences between the GS-6 and GS-7 groups and the GS-7 and GS-9 groups (p < 0.05). The ADC value of the GS-6 group was significantly higher than each value of the GS-7, GS-8, and GS-9 groups (p < 0.05), but no significant differences were obtained among the GS-7, GS-8, and GS-9 groups. Conclusion: The mean APT SI in Pca with a GS of 7 was higher than that for the other GS groups.",
author = "Yukihisa Takayama and Akihiro Nishie and Masaaki Sugimoto and Osamu Togao and Yoshiki Asayama and Kousei Ishigami and Yasuhiro Ushijima and Daisuke Okamoto and Nobuhiro Fujita and Akira Yokomizo and Jochen Keupp and Hiroshi Honda",
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T1 - Amide proton transfer (APT) magnetic resonance imaging of prostate cancer

T2 - comparison with Gleason scores

AU - Takayama, Yukihisa

AU - Nishie, Akihiro

AU - Sugimoto, Masaaki

AU - Togao, Osamu

AU - Asayama, Yoshiki

AU - Ishigami, Kousei

AU - Ushijima, Yasuhiro

AU - Okamoto, Daisuke

AU - Fujita, Nobuhiro

AU - Yokomizo, Akira

AU - Keupp, Jochen

AU - Honda, Hiroshi

PY - 2016/8/1

Y1 - 2016/8/1

N2 - Objective: To evaluate the utility of amide proton transfer (APT) imaging in estimating the Gleason score (GS) of prostate cancer (Pca). Materials and methods: Sixty-six biopsy-proven cancers were categorized into four groups according to the GS: GS-6 (3 + 3); GS-7 (3 + 4/4 + 3); GS-8 (4 + 4) and GS-9 (4 + 5/5 + 4). APT signal intensities (APT SIs) and apparent diffusion coefficient (ADC) values of each GS group were compared by one-way analysis of variance with Tukey’s HSD post hoc test. Results: The mean and standard deviation of the APT SIs (%) and ADC values (×10−3 mm2/s) were as follows: GS-6, 2.48 ± 0.59 and 1.16 ± 0.26; GS-7, 5.17 ± 0.66 and 0.92 ± 0.18; GS-8, 2.56 ± 0.85 and 0.86 ± 0.17; GS-9, 1.96 ± 0.75 and 0.85 ± 0.18, respectively. The APT SI of the GS-7 group was highest, and there were significant differences between the GS-6 and GS-7 groups and the GS-7 and GS-9 groups (p < 0.05). The ADC value of the GS-6 group was significantly higher than each value of the GS-7, GS-8, and GS-9 groups (p < 0.05), but no significant differences were obtained among the GS-7, GS-8, and GS-9 groups. Conclusion: The mean APT SI in Pca with a GS of 7 was higher than that for the other GS groups.

AB - Objective: To evaluate the utility of amide proton transfer (APT) imaging in estimating the Gleason score (GS) of prostate cancer (Pca). Materials and methods: Sixty-six biopsy-proven cancers were categorized into four groups according to the GS: GS-6 (3 + 3); GS-7 (3 + 4/4 + 3); GS-8 (4 + 4) and GS-9 (4 + 5/5 + 4). APT signal intensities (APT SIs) and apparent diffusion coefficient (ADC) values of each GS group were compared by one-way analysis of variance with Tukey’s HSD post hoc test. Results: The mean and standard deviation of the APT SIs (%) and ADC values (×10−3 mm2/s) were as follows: GS-6, 2.48 ± 0.59 and 1.16 ± 0.26; GS-7, 5.17 ± 0.66 and 0.92 ± 0.18; GS-8, 2.56 ± 0.85 and 0.86 ± 0.17; GS-9, 1.96 ± 0.75 and 0.85 ± 0.18, respectively. The APT SI of the GS-7 group was highest, and there were significant differences between the GS-6 and GS-7 groups and the GS-7 and GS-9 groups (p < 0.05). The ADC value of the GS-6 group was significantly higher than each value of the GS-7, GS-8, and GS-9 groups (p < 0.05), but no significant differences were obtained among the GS-7, GS-8, and GS-9 groups. Conclusion: The mean APT SI in Pca with a GS of 7 was higher than that for the other GS groups.

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