Abstract
Purpose: To prospectively investigate the ability of amide proton transfer (APT) imaging, in comparison with that of diffusion-weighted imaging (DWI), to predict pathological factors in rectal cancer. Materials and methods: Twenty-two patients who underwent MR examination including APT imaging and DWI for evaluation of rectal cancer were enrolled. APT signal intensity (SI) was defined as the magnetization transfer asymmetry at 3.5 ppm and was mapped. An apparent diffusion coefficient (ADC) map was generated using b-values of 0, 500 and 1000 s/mm 2 . APT SI and ADC were calculated by placing regions-of-interest in the tumors on these maps. Pathological factors including tumor size and tumor grade were also evaluated. Average APT SIs or ADCs were compared between the two groups classified based on each pathological factor using Student's t-test. Results: The average APT SI of tumors with diameters of 5 cm or more (3.09 ± 1.41%) was significantly higher than that of tumors with diameters < 5 cm (1.83 ± 1.38%). In addition, the average APT SI of moderately differentiated adenocarcinoma (2.82 ± 1.51%) was significantly higher than that of well-differentiated adenocarcinoma (1.24 ± 0.57%). There was no difference in ADC between groups classified based on any pathological factor. Conclusion: Amide proton transfer imaging can predict tumor grade in rectal cancer.
| Original language | English |
|---|---|
| Pages (from-to) | 96-103 |
| Number of pages | 8 |
| Journal | Magnetic Resonance Imaging |
| Volume | 51 |
| DOIs | |
| Publication status | Published - Sep 1 2018 |
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All Science Journal Classification (ASJC) codes
- Biophysics
- Biomedical Engineering
- Radiology Nuclear Medicine and imaging
Cite this
Amide proton transfer imaging can predict tumor grade in rectal cancer. / Nishie, Akihiro; Takayama, Yukihisa; Asayama, Yoshiki; Ishigami, Kosei; ushijima, yasuhiro; Okamoto, Daisuke; fujita, nobuhiro; Tsurumaru, Daisuke; Togao, Osamu; Manabe, Tatsuya; Oki, Eiji; kubo, yuichiro; Hida, Tomoyuki; Hirahashi-Fujiwara, Minako; Keupp, Jochen; Honda, Hiroshi.
In: Magnetic Resonance Imaging, Vol. 51, 01.09.2018, p. 96-103.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Amide proton transfer imaging can predict tumor grade in rectal cancer
AU - Nishie, Akihiro
AU - Takayama, Yukihisa
AU - Asayama, Yoshiki
AU - Ishigami, Kosei
AU - ushijima, yasuhiro
AU - Okamoto, Daisuke
AU - fujita, nobuhiro
AU - Tsurumaru, Daisuke
AU - Togao, Osamu
AU - Manabe, Tatsuya
AU - Oki, Eiji
AU - kubo, yuichiro
AU - Hida, Tomoyuki
AU - Hirahashi-Fujiwara, Minako
AU - Keupp, Jochen
AU - Honda, Hiroshi
PY - 2018/9/1
Y1 - 2018/9/1
N2 - Purpose: To prospectively investigate the ability of amide proton transfer (APT) imaging, in comparison with that of diffusion-weighted imaging (DWI), to predict pathological factors in rectal cancer. Materials and methods: Twenty-two patients who underwent MR examination including APT imaging and DWI for evaluation of rectal cancer were enrolled. APT signal intensity (SI) was defined as the magnetization transfer asymmetry at 3.5 ppm and was mapped. An apparent diffusion coefficient (ADC) map was generated using b-values of 0, 500 and 1000 s/mm 2 . APT SI and ADC were calculated by placing regions-of-interest in the tumors on these maps. Pathological factors including tumor size and tumor grade were also evaluated. Average APT SIs or ADCs were compared between the two groups classified based on each pathological factor using Student's t-test. Results: The average APT SI of tumors with diameters of 5 cm or more (3.09 ± 1.41%) was significantly higher than that of tumors with diameters < 5 cm (1.83 ± 1.38%). In addition, the average APT SI of moderately differentiated adenocarcinoma (2.82 ± 1.51%) was significantly higher than that of well-differentiated adenocarcinoma (1.24 ± 0.57%). There was no difference in ADC between groups classified based on any pathological factor. Conclusion: Amide proton transfer imaging can predict tumor grade in rectal cancer.
AB - Purpose: To prospectively investigate the ability of amide proton transfer (APT) imaging, in comparison with that of diffusion-weighted imaging (DWI), to predict pathological factors in rectal cancer. Materials and methods: Twenty-two patients who underwent MR examination including APT imaging and DWI for evaluation of rectal cancer were enrolled. APT signal intensity (SI) was defined as the magnetization transfer asymmetry at 3.5 ppm and was mapped. An apparent diffusion coefficient (ADC) map was generated using b-values of 0, 500 and 1000 s/mm 2 . APT SI and ADC were calculated by placing regions-of-interest in the tumors on these maps. Pathological factors including tumor size and tumor grade were also evaluated. Average APT SIs or ADCs were compared between the two groups classified based on each pathological factor using Student's t-test. Results: The average APT SI of tumors with diameters of 5 cm or more (3.09 ± 1.41%) was significantly higher than that of tumors with diameters < 5 cm (1.83 ± 1.38%). In addition, the average APT SI of moderately differentiated adenocarcinoma (2.82 ± 1.51%) was significantly higher than that of well-differentiated adenocarcinoma (1.24 ± 0.57%). There was no difference in ADC between groups classified based on any pathological factor. Conclusion: Amide proton transfer imaging can predict tumor grade in rectal cancer.
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UR - http://www.scopus.com/inward/citedby.url?scp=85046648558&partnerID=8YFLogxK
U2 - 10.1016/j.mri.2018.04.017
DO - 10.1016/j.mri.2018.04.017
M3 - Article
C2 - 29729438
AN - SCOPUS:85046648558
VL - 51
SP - 96
EP - 103
JO - Magnetic Resonance Imaging
JF - Magnetic Resonance Imaging
SN - 0730-725X
ER -