Amide proton transfer imaging can predict tumor grade in rectal cancer

Akihiro Nishie, Yukihisa Takayama, Yoshiki Asayama, Kosei Ishigami, yasuhiro ushijima, Daisuke Okamoto, nobuhiro fujita, Daisuke Tsurumaru, Osamu Togao, Tatsuya Manabe, Eiji Oki, yuichiro kubo, Tomoyuki Hida, Minako Hirahashi-Fujiwara, Jochen Keupp, Hiroshi Honda

Research output: Contribution to journalArticle

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Abstract

Purpose: To prospectively investigate the ability of amide proton transfer (APT) imaging, in comparison with that of diffusion-weighted imaging (DWI), to predict pathological factors in rectal cancer. Materials and methods: Twenty-two patients who underwent MR examination including APT imaging and DWI for evaluation of rectal cancer were enrolled. APT signal intensity (SI) was defined as the magnetization transfer asymmetry at 3.5 ppm and was mapped. An apparent diffusion coefficient (ADC) map was generated using b-values of 0, 500 and 1000 s/mm 2 . APT SI and ADC were calculated by placing regions-of-interest in the tumors on these maps. Pathological factors including tumor size and tumor grade were also evaluated. Average APT SIs or ADCs were compared between the two groups classified based on each pathological factor using Student's t-test. Results: The average APT SI of tumors with diameters of 5 cm or more (3.09 ± 1.41%) was significantly higher than that of tumors with diameters < 5 cm (1.83 ± 1.38%). In addition, the average APT SI of moderately differentiated adenocarcinoma (2.82 ± 1.51%) was significantly higher than that of well-differentiated adenocarcinoma (1.24 ± 0.57%). There was no difference in ADC between groups classified based on any pathological factor. Conclusion: Amide proton transfer imaging can predict tumor grade in rectal cancer.

Original languageEnglish
Pages (from-to)96-103
Number of pages8
JournalMagnetic Resonance Imaging
Volume51
DOIs
Publication statusPublished - Sep 1 2018

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Proton transfer
Rectal Neoplasms
Amides
Protons
Tumors
Imaging techniques
Neoplasms
Adenocarcinoma
Magnetization
Students

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Biomedical Engineering
  • Radiology Nuclear Medicine and imaging

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Amide proton transfer imaging can predict tumor grade in rectal cancer. / Nishie, Akihiro; Takayama, Yukihisa; Asayama, Yoshiki; Ishigami, Kosei; ushijima, yasuhiro; Okamoto, Daisuke; fujita, nobuhiro; Tsurumaru, Daisuke; Togao, Osamu; Manabe, Tatsuya; Oki, Eiji; kubo, yuichiro; Hida, Tomoyuki; Hirahashi-Fujiwara, Minako; Keupp, Jochen; Honda, Hiroshi.

In: Magnetic Resonance Imaging, Vol. 51, 01.09.2018, p. 96-103.

Research output: Contribution to journalArticle

Nishie, Akihiro ; Takayama, Yukihisa ; Asayama, Yoshiki ; Ishigami, Kosei ; ushijima, yasuhiro ; Okamoto, Daisuke ; fujita, nobuhiro ; Tsurumaru, Daisuke ; Togao, Osamu ; Manabe, Tatsuya ; Oki, Eiji ; kubo, yuichiro ; Hida, Tomoyuki ; Hirahashi-Fujiwara, Minako ; Keupp, Jochen ; Honda, Hiroshi. / Amide proton transfer imaging can predict tumor grade in rectal cancer. In: Magnetic Resonance Imaging. 2018 ; Vol. 51. pp. 96-103.
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abstract = "Purpose: To prospectively investigate the ability of amide proton transfer (APT) imaging, in comparison with that of diffusion-weighted imaging (DWI), to predict pathological factors in rectal cancer. Materials and methods: Twenty-two patients who underwent MR examination including APT imaging and DWI for evaluation of rectal cancer were enrolled. APT signal intensity (SI) was defined as the magnetization transfer asymmetry at 3.5 ppm and was mapped. An apparent diffusion coefficient (ADC) map was generated using b-values of 0, 500 and 1000 s/mm 2 . APT SI and ADC were calculated by placing regions-of-interest in the tumors on these maps. Pathological factors including tumor size and tumor grade were also evaluated. Average APT SIs or ADCs were compared between the two groups classified based on each pathological factor using Student's t-test. Results: The average APT SI of tumors with diameters of 5 cm or more (3.09 ± 1.41{\%}) was significantly higher than that of tumors with diameters < 5 cm (1.83 ± 1.38{\%}). In addition, the average APT SI of moderately differentiated adenocarcinoma (2.82 ± 1.51{\%}) was significantly higher than that of well-differentiated adenocarcinoma (1.24 ± 0.57{\%}). There was no difference in ADC between groups classified based on any pathological factor. Conclusion: Amide proton transfer imaging can predict tumor grade in rectal cancer.",
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AU - Nishie, Akihiro

AU - Takayama, Yukihisa

AU - Asayama, Yoshiki

AU - Ishigami, Kosei

AU - ushijima, yasuhiro

AU - Okamoto, Daisuke

AU - fujita, nobuhiro

AU - Tsurumaru, Daisuke

AU - Togao, Osamu

AU - Manabe, Tatsuya

AU - Oki, Eiji

AU - kubo, yuichiro

AU - Hida, Tomoyuki

AU - Hirahashi-Fujiwara, Minako

AU - Keupp, Jochen

AU - Honda, Hiroshi

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Y1 - 2018/9/1

N2 - Purpose: To prospectively investigate the ability of amide proton transfer (APT) imaging, in comparison with that of diffusion-weighted imaging (DWI), to predict pathological factors in rectal cancer. Materials and methods: Twenty-two patients who underwent MR examination including APT imaging and DWI for evaluation of rectal cancer were enrolled. APT signal intensity (SI) was defined as the magnetization transfer asymmetry at 3.5 ppm and was mapped. An apparent diffusion coefficient (ADC) map was generated using b-values of 0, 500 and 1000 s/mm 2 . APT SI and ADC were calculated by placing regions-of-interest in the tumors on these maps. Pathological factors including tumor size and tumor grade were also evaluated. Average APT SIs or ADCs were compared between the two groups classified based on each pathological factor using Student's t-test. Results: The average APT SI of tumors with diameters of 5 cm or more (3.09 ± 1.41%) was significantly higher than that of tumors with diameters < 5 cm (1.83 ± 1.38%). In addition, the average APT SI of moderately differentiated adenocarcinoma (2.82 ± 1.51%) was significantly higher than that of well-differentiated adenocarcinoma (1.24 ± 0.57%). There was no difference in ADC between groups classified based on any pathological factor. Conclusion: Amide proton transfer imaging can predict tumor grade in rectal cancer.

AB - Purpose: To prospectively investigate the ability of amide proton transfer (APT) imaging, in comparison with that of diffusion-weighted imaging (DWI), to predict pathological factors in rectal cancer. Materials and methods: Twenty-two patients who underwent MR examination including APT imaging and DWI for evaluation of rectal cancer were enrolled. APT signal intensity (SI) was defined as the magnetization transfer asymmetry at 3.5 ppm and was mapped. An apparent diffusion coefficient (ADC) map was generated using b-values of 0, 500 and 1000 s/mm 2 . APT SI and ADC were calculated by placing regions-of-interest in the tumors on these maps. Pathological factors including tumor size and tumor grade were also evaluated. Average APT SIs or ADCs were compared between the two groups classified based on each pathological factor using Student's t-test. Results: The average APT SI of tumors with diameters of 5 cm or more (3.09 ± 1.41%) was significantly higher than that of tumors with diameters < 5 cm (1.83 ± 1.38%). In addition, the average APT SI of moderately differentiated adenocarcinoma (2.82 ± 1.51%) was significantly higher than that of well-differentiated adenocarcinoma (1.24 ± 0.57%). There was no difference in ADC between groups classified based on any pathological factor. Conclusion: Amide proton transfer imaging can predict tumor grade in rectal cancer.

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