Amide proton transfer imaging for differentiating benign ovarian cystic lesions: Potential of first time right

Keisuke Ishimatsu, Akihiro Nishie, Yukihisa Takayama, Yoshiki Asayama, Yasuhiro Ushijima, Daisuke Kakihara, Koichiro Morita, Seiichiro Takao, Kenzo Sonoda, Yoshihiro Ohishi, Hiroshi Honda

Research output: Contribution to journalArticle

Abstract

Purpose: To investigate whether amide proton transfer (APT) imaging is useful to differentiate benign ovarian cystic lesions. Materials and methods: This prospective study enrolled a total of 19 lesions in 18 patients with benign ovarian cystic lesion: serous cystadenoma (SCA), n = 4; mucinous cystadenoma (MCA), n = 9; or functional cyst (FC), n = 6. APT imaging was performed with three different presaturation pulse durations: 0.5, 1.0 and 2.0 s. APT signal was defined as magnetization transfer ratio asymmetry at 3.5 ppm. The SI ratios of cyst to muscle calculated on T1- and T2-weighted images were defined as T1- and T2-ratios. Apparent diffusion coefficient (ADC) maps were also generated. We compared the three cystic lesion groups’ APT signals, T1-ratio, T2-ratio, and ADC. Results: When using 2.0 s of presaturation, the APT signals were 1.41 ± 0.71% in SCA, 5.15 ± 1.92% in MCA and 8.52 ± 1.17% in FC. Significant differences were observed between SCA and MCA (p <.01) and MCA and FC (p <.05), as well as between SCA and FC (P <.0001). When 1.0 s presaturation pulse was used, similar results were obtained. On the other hand, ADC value shows significance only between SCA (2.91±0.03×10−3 mm2/s) and MCA (2.59 ± 0.49 × 10−3 mm2/s, p <.05). Further, there was no significant difference in the T1-ratio, T2-ratio among the three groups. Conclusions: APT imaging might be useful for the non-invasive diagnosis of benign ovarian cystic lesions. With the use of the longer presaturation pulse as possible, APT imaging may provide an early and correct diagnosis of ovarian cystic lesions without additional follow-up studies.

Original languageEnglish
Article number108656
JournalEuropean Journal of Radiology
Volume120
DOIs
Publication statusPublished - Nov 2019

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Serous Cystadenoma
Mucinous Cystadenoma
Amides
Protons
Cysts
Early Diagnosis
Prospective Studies
Muscles

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging

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Amide proton transfer imaging for differentiating benign ovarian cystic lesions : Potential of first time right. / Ishimatsu, Keisuke; Nishie, Akihiro; Takayama, Yukihisa; Asayama, Yoshiki; Ushijima, Yasuhiro; Kakihara, Daisuke; Morita, Koichiro; Takao, Seiichiro; Sonoda, Kenzo; Ohishi, Yoshihiro; Honda, Hiroshi.

In: European Journal of Radiology, Vol. 120, 108656, 11.2019.

Research output: Contribution to journalArticle

Ishimatsu, Keisuke ; Nishie, Akihiro ; Takayama, Yukihisa ; Asayama, Yoshiki ; Ushijima, Yasuhiro ; Kakihara, Daisuke ; Morita, Koichiro ; Takao, Seiichiro ; Sonoda, Kenzo ; Ohishi, Yoshihiro ; Honda, Hiroshi. / Amide proton transfer imaging for differentiating benign ovarian cystic lesions : Potential of first time right. In: European Journal of Radiology. 2019 ; Vol. 120.
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abstract = "Purpose: To investigate whether amide proton transfer (APT) imaging is useful to differentiate benign ovarian cystic lesions. Materials and methods: This prospective study enrolled a total of 19 lesions in 18 patients with benign ovarian cystic lesion: serous cystadenoma (SCA), n = 4; mucinous cystadenoma (MCA), n = 9; or functional cyst (FC), n = 6. APT imaging was performed with three different presaturation pulse durations: 0.5, 1.0 and 2.0 s. APT signal was defined as magnetization transfer ratio asymmetry at 3.5 ppm. The SI ratios of cyst to muscle calculated on T1- and T2-weighted images were defined as T1- and T2-ratios. Apparent diffusion coefficient (ADC) maps were also generated. We compared the three cystic lesion groups’ APT signals, T1-ratio, T2-ratio, and ADC. Results: When using 2.0 s of presaturation, the APT signals were 1.41 ± 0.71{\%} in SCA, 5.15 ± 1.92{\%} in MCA and 8.52 ± 1.17{\%} in FC. Significant differences were observed between SCA and MCA (p <.01) and MCA and FC (p <.05), as well as between SCA and FC (P <.0001). When 1.0 s presaturation pulse was used, similar results were obtained. On the other hand, ADC value shows significance only between SCA (2.91±0.03×10−3 mm2/s) and MCA (2.59 ± 0.49 × 10−3 mm2/s, p <.05). Further, there was no significant difference in the T1-ratio, T2-ratio among the three groups. Conclusions: APT imaging might be useful for the non-invasive diagnosis of benign ovarian cystic lesions. With the use of the longer presaturation pulse as possible, APT imaging may provide an early and correct diagnosis of ovarian cystic lesions without additional follow-up studies.",
author = "Keisuke Ishimatsu and Akihiro Nishie and Yukihisa Takayama and Yoshiki Asayama and Yasuhiro Ushijima and Daisuke Kakihara and Koichiro Morita and Seiichiro Takao and Kenzo Sonoda and Yoshihiro Ohishi and Hiroshi Honda",
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T1 - Amide proton transfer imaging for differentiating benign ovarian cystic lesions

T2 - Potential of first time right

AU - Ishimatsu, Keisuke

AU - Nishie, Akihiro

AU - Takayama, Yukihisa

AU - Asayama, Yoshiki

AU - Ushijima, Yasuhiro

AU - Kakihara, Daisuke

AU - Morita, Koichiro

AU - Takao, Seiichiro

AU - Sonoda, Kenzo

AU - Ohishi, Yoshihiro

AU - Honda, Hiroshi

PY - 2019/11

Y1 - 2019/11

N2 - Purpose: To investigate whether amide proton transfer (APT) imaging is useful to differentiate benign ovarian cystic lesions. Materials and methods: This prospective study enrolled a total of 19 lesions in 18 patients with benign ovarian cystic lesion: serous cystadenoma (SCA), n = 4; mucinous cystadenoma (MCA), n = 9; or functional cyst (FC), n = 6. APT imaging was performed with three different presaturation pulse durations: 0.5, 1.0 and 2.0 s. APT signal was defined as magnetization transfer ratio asymmetry at 3.5 ppm. The SI ratios of cyst to muscle calculated on T1- and T2-weighted images were defined as T1- and T2-ratios. Apparent diffusion coefficient (ADC) maps were also generated. We compared the three cystic lesion groups’ APT signals, T1-ratio, T2-ratio, and ADC. Results: When using 2.0 s of presaturation, the APT signals were 1.41 ± 0.71% in SCA, 5.15 ± 1.92% in MCA and 8.52 ± 1.17% in FC. Significant differences were observed between SCA and MCA (p <.01) and MCA and FC (p <.05), as well as between SCA and FC (P <.0001). When 1.0 s presaturation pulse was used, similar results were obtained. On the other hand, ADC value shows significance only between SCA (2.91±0.03×10−3 mm2/s) and MCA (2.59 ± 0.49 × 10−3 mm2/s, p <.05). Further, there was no significant difference in the T1-ratio, T2-ratio among the three groups. Conclusions: APT imaging might be useful for the non-invasive diagnosis of benign ovarian cystic lesions. With the use of the longer presaturation pulse as possible, APT imaging may provide an early and correct diagnosis of ovarian cystic lesions without additional follow-up studies.

AB - Purpose: To investigate whether amide proton transfer (APT) imaging is useful to differentiate benign ovarian cystic lesions. Materials and methods: This prospective study enrolled a total of 19 lesions in 18 patients with benign ovarian cystic lesion: serous cystadenoma (SCA), n = 4; mucinous cystadenoma (MCA), n = 9; or functional cyst (FC), n = 6. APT imaging was performed with three different presaturation pulse durations: 0.5, 1.0 and 2.0 s. APT signal was defined as magnetization transfer ratio asymmetry at 3.5 ppm. The SI ratios of cyst to muscle calculated on T1- and T2-weighted images were defined as T1- and T2-ratios. Apparent diffusion coefficient (ADC) maps were also generated. We compared the three cystic lesion groups’ APT signals, T1-ratio, T2-ratio, and ADC. Results: When using 2.0 s of presaturation, the APT signals were 1.41 ± 0.71% in SCA, 5.15 ± 1.92% in MCA and 8.52 ± 1.17% in FC. Significant differences were observed between SCA and MCA (p <.01) and MCA and FC (p <.05), as well as between SCA and FC (P <.0001). When 1.0 s presaturation pulse was used, similar results were obtained. On the other hand, ADC value shows significance only between SCA (2.91±0.03×10−3 mm2/s) and MCA (2.59 ± 0.49 × 10−3 mm2/s, p <.05). Further, there was no significant difference in the T1-ratio, T2-ratio among the three groups. Conclusions: APT imaging might be useful for the non-invasive diagnosis of benign ovarian cystic lesions. With the use of the longer presaturation pulse as possible, APT imaging may provide an early and correct diagnosis of ovarian cystic lesions without additional follow-up studies.

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