TY - JOUR
T1 - Amide proton transfer MR imaging of endometrioid endometrial adenocarcinoma
T2 - Association with histologic grade
AU - Takayama, Yukihisa
AU - Nishie, Akihiro
AU - Togao, Osamu
AU - Asayama, Yoshiki
AU - Ishigami, Kousei
AU - Ushijima, Yasuhiro
AU - Okamoto, Daisuke
AU - Fujita, Nobuhiro
AU - Sonoda, Kenzo
AU - Hida, Tomoyuki
AU - Ohishi, Yoshihiro
AU - Keupp, Jochen
AU - Honda, Hiroshi
N1 - Funding Information:
Supported by Grant-in-Aid for Scientific Research (C) (Japan Society for the Promotion of Science, KAKENHI 25461833).
Funding Information:
no relevant relationships. A.N. disclosed no relevant relationships. O.T. disclosed no relevant relationships. Y.A. disclosed no relevant relationships. K.T. disclosed no relevant relationships. Y.U. disclosed no relevant relationships. D.O. disclosed no relevant relationships. N.F. disclosed no relevant relationships. K.S. disclosed no relevant relationships. T.H. disclosed no relevant relationships. Y.O. disclosed no relevant relationships. J.K. Activities related to the present article: disclosed no relevant relationships. Activities not related to the present article: is an employee of Philips Research; reports grants from the National Cancer Institute (NCI R01CA166171) and European Commission (EU FP7 603028 iPaCT). Other relationships: disclosed no relevant relationships. H.H. disclosed no relevant relationships.
PY - 2018/3
Y1 - 2018/3
N2 - Purpose: To evaluate the utility of amide proton transfer (APT) imaging in estimating histologic grades of endometrioid endometrial adenocarcinoma (EEA). Materials and The institutional review board approved this prospective Methods: study. Between June 2012 and March 2016, 32 patients with EEA underwent magnetic resonance (MR) imaging. After their surgical procedures, their EEAs were confirmed pathologically and classified into histologic grades: grade 1 (n = 11), grade 2 (n = 11), and grade 3 (n = 10). The APT signal intensities (SIs) and the mean and minimum apparent diffusion coefficients (ADCs) of the three grades were calculated and compared. Spearman rank correlation coefficient was also calculated between the APT SIs and histologic grades, and between the ADCs and histologic grades. Results: The Spearman correlation coefficient with histologic grade of the APT SIs, the mean ADC, and the minimum ADC were 0.55 (P = .001), 0.03 (P = .84), and 20.30 (P = .09), respectively. The average APT SIs and the mean and minimum ADCs were 2.2% 6 0.2 (standard deviation), 0.9 3 1023 mm2/sec 6 0.2, and 0.6 3 1023 mm2/sec 6 0.1 for grade 1; 3.2% 6 0.3, 0.8 3 1023 mm2/sec 6 0.1, and 0.5 3 1023 mm2/sec 6 0.1 for grade 2; and 3.7% 6 0.3, 0.9 3 1023 mm2/sec 6 0.1, and 0.5 3 1023 mm2/sec 6 0.1 for grade 3, respectively. The APT SIs of grade 3 EEA were significantly higher than those of grade 1 EEA (P = .01), but other pairwise comparisons did not reveal any significant differences (P = .06-.51). The mean and minimum ADCs showed no significant differences among the three histologic grades (P =.13-.51). Conclusion: The APT SI was positively correlated with the histologic grades of EEA.
AB - Purpose: To evaluate the utility of amide proton transfer (APT) imaging in estimating histologic grades of endometrioid endometrial adenocarcinoma (EEA). Materials and The institutional review board approved this prospective Methods: study. Between June 2012 and March 2016, 32 patients with EEA underwent magnetic resonance (MR) imaging. After their surgical procedures, their EEAs were confirmed pathologically and classified into histologic grades: grade 1 (n = 11), grade 2 (n = 11), and grade 3 (n = 10). The APT signal intensities (SIs) and the mean and minimum apparent diffusion coefficients (ADCs) of the three grades were calculated and compared. Spearman rank correlation coefficient was also calculated between the APT SIs and histologic grades, and between the ADCs and histologic grades. Results: The Spearman correlation coefficient with histologic grade of the APT SIs, the mean ADC, and the minimum ADC were 0.55 (P = .001), 0.03 (P = .84), and 20.30 (P = .09), respectively. The average APT SIs and the mean and minimum ADCs were 2.2% 6 0.2 (standard deviation), 0.9 3 1023 mm2/sec 6 0.2, and 0.6 3 1023 mm2/sec 6 0.1 for grade 1; 3.2% 6 0.3, 0.8 3 1023 mm2/sec 6 0.1, and 0.5 3 1023 mm2/sec 6 0.1 for grade 2; and 3.7% 6 0.3, 0.9 3 1023 mm2/sec 6 0.1, and 0.5 3 1023 mm2/sec 6 0.1 for grade 3, respectively. The APT SIs of grade 3 EEA were significantly higher than those of grade 1 EEA (P = .01), but other pairwise comparisons did not reveal any significant differences (P = .06-.51). The mean and minimum ADCs showed no significant differences among the three histologic grades (P =.13-.51). Conclusion: The APT SI was positively correlated with the histologic grades of EEA.
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U2 - 10.1148/radiol.2017170349
DO - 10.1148/radiol.2017170349
M3 - Article
C2 - 29083987
AN - SCOPUS:85042451012
VL - 286
SP - 909
EP - 917
JO - Radiology
JF - Radiology
SN - 0033-8419
IS - 3
ER -