Amide proton transfer MR imaging of endometrioid endometrial adenocarcinoma: Association with histologic grade

Yukihisa Takayama, Akihiro Nishie, Osamu Togao, Yoshiki Asayama, Kosei Ishigami, yasuhiro ushijima, Daisuke Okamoto, nobuhiro fujita, Kenzo Sonoda, Tomoyuki Hida, Yoshihiro Ohishi, Jochen Keupp, Hiroshi Honda

Research output: Contribution to journalArticle

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Abstract

Purpose: To evaluate the utility of amide proton transfer (APT) imaging in estimating histologic grades of endometrioid endometrial adenocarcinoma (EEA). Materials and The institutional review board approved this prospective Methods: study. Between June 2012 and March 2016, 32 patients with EEA underwent magnetic resonance (MR) imaging. After their surgical procedures, their EEAs were confirmed pathologically and classified into histologic grades: grade 1 (n = 11), grade 2 (n = 11), and grade 3 (n = 10). The APT signal intensities (SIs) and the mean and minimum apparent diffusion coefficients (ADCs) of the three grades were calculated and compared. Spearman rank correlation coefficient was also calculated between the APT SIs and histologic grades, and between the ADCs and histologic grades. Results: The Spearman correlation coefficient with histologic grade of the APT SIs, the mean ADC, and the minimum ADC were 0.55 (P = .001), 0.03 (P = .84), and 20.30 (P = .09), respectively. The average APT SIs and the mean and minimum ADCs were 2.2% 6 0.2 (standard deviation), 0.9 3 1023 mm2/sec 6 0.2, and 0.6 3 1023 mm2/sec 6 0.1 for grade 1; 3.2% 6 0.3, 0.8 3 1023 mm2/sec 6 0.1, and 0.5 3 1023 mm2/sec 6 0.1 for grade 2; and 3.7% 6 0.3, 0.9 3 1023 mm2/sec 6 0.1, and 0.5 3 1023 mm2/sec 6 0.1 for grade 3, respectively. The APT SIs of grade 3 EEA were significantly higher than those of grade 1 EEA (P = .01), but other pairwise comparisons did not reveal any significant differences (P = .06-.51). The mean and minimum ADCs showed no significant differences among the three histologic grades (P =.13-.51). Conclusion: The APT SI was positively correlated with the histologic grades of EEA.

Original languageEnglish
Pages (from-to)909-917
Number of pages9
JournalRadiology
Volume286
Issue number3
DOIs
Publication statusPublished - Mar 1 2018

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Endometrioid Carcinoma
Amides
Protons
Magnetic Resonance Imaging
Research Ethics Committees
Nonparametric Statistics
Prospective Studies

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging

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Amide proton transfer MR imaging of endometrioid endometrial adenocarcinoma : Association with histologic grade. / Takayama, Yukihisa; Nishie, Akihiro; Togao, Osamu; Asayama, Yoshiki; Ishigami, Kosei; ushijima, yasuhiro; Okamoto, Daisuke; fujita, nobuhiro; Sonoda, Kenzo; Hida, Tomoyuki; Ohishi, Yoshihiro; Keupp, Jochen; Honda, Hiroshi.

In: Radiology, Vol. 286, No. 3, 01.03.2018, p. 909-917.

Research output: Contribution to journalArticle

Takayama, Yukihisa ; Nishie, Akihiro ; Togao, Osamu ; Asayama, Yoshiki ; Ishigami, Kosei ; ushijima, yasuhiro ; Okamoto, Daisuke ; fujita, nobuhiro ; Sonoda, Kenzo ; Hida, Tomoyuki ; Ohishi, Yoshihiro ; Keupp, Jochen ; Honda, Hiroshi. / Amide proton transfer MR imaging of endometrioid endometrial adenocarcinoma : Association with histologic grade. In: Radiology. 2018 ; Vol. 286, No. 3. pp. 909-917.
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abstract = "Purpose: To evaluate the utility of amide proton transfer (APT) imaging in estimating histologic grades of endometrioid endometrial adenocarcinoma (EEA). Materials and The institutional review board approved this prospective Methods: study. Between June 2012 and March 2016, 32 patients with EEA underwent magnetic resonance (MR) imaging. After their surgical procedures, their EEAs were confirmed pathologically and classified into histologic grades: grade 1 (n = 11), grade 2 (n = 11), and grade 3 (n = 10). The APT signal intensities (SIs) and the mean and minimum apparent diffusion coefficients (ADCs) of the three grades were calculated and compared. Spearman rank correlation coefficient was also calculated between the APT SIs and histologic grades, and between the ADCs and histologic grades. Results: The Spearman correlation coefficient with histologic grade of the APT SIs, the mean ADC, and the minimum ADC were 0.55 (P = .001), 0.03 (P = .84), and 20.30 (P = .09), respectively. The average APT SIs and the mean and minimum ADCs were 2.2{\%} 6 0.2 (standard deviation), 0.9 3 1023 mm2/sec 6 0.2, and 0.6 3 1023 mm2/sec 6 0.1 for grade 1; 3.2{\%} 6 0.3, 0.8 3 1023 mm2/sec 6 0.1, and 0.5 3 1023 mm2/sec 6 0.1 for grade 2; and 3.7{\%} 6 0.3, 0.9 3 1023 mm2/sec 6 0.1, and 0.5 3 1023 mm2/sec 6 0.1 for grade 3, respectively. The APT SIs of grade 3 EEA were significantly higher than those of grade 1 EEA (P = .01), but other pairwise comparisons did not reveal any significant differences (P = .06-.51). The mean and minimum ADCs showed no significant differences among the three histologic grades (P =.13-.51). Conclusion: The APT SI was positively correlated with the histologic grades of EEA.",
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T1 - Amide proton transfer MR imaging of endometrioid endometrial adenocarcinoma

T2 - Association with histologic grade

AU - Takayama, Yukihisa

AU - Nishie, Akihiro

AU - Togao, Osamu

AU - Asayama, Yoshiki

AU - Ishigami, Kosei

AU - ushijima, yasuhiro

AU - Okamoto, Daisuke

AU - fujita, nobuhiro

AU - Sonoda, Kenzo

AU - Hida, Tomoyuki

AU - Ohishi, Yoshihiro

AU - Keupp, Jochen

AU - Honda, Hiroshi

PY - 2018/3/1

Y1 - 2018/3/1

N2 - Purpose: To evaluate the utility of amide proton transfer (APT) imaging in estimating histologic grades of endometrioid endometrial adenocarcinoma (EEA). Materials and The institutional review board approved this prospective Methods: study. Between June 2012 and March 2016, 32 patients with EEA underwent magnetic resonance (MR) imaging. After their surgical procedures, their EEAs were confirmed pathologically and classified into histologic grades: grade 1 (n = 11), grade 2 (n = 11), and grade 3 (n = 10). The APT signal intensities (SIs) and the mean and minimum apparent diffusion coefficients (ADCs) of the three grades were calculated and compared. Spearman rank correlation coefficient was also calculated between the APT SIs and histologic grades, and between the ADCs and histologic grades. Results: The Spearman correlation coefficient with histologic grade of the APT SIs, the mean ADC, and the minimum ADC were 0.55 (P = .001), 0.03 (P = .84), and 20.30 (P = .09), respectively. The average APT SIs and the mean and minimum ADCs were 2.2% 6 0.2 (standard deviation), 0.9 3 1023 mm2/sec 6 0.2, and 0.6 3 1023 mm2/sec 6 0.1 for grade 1; 3.2% 6 0.3, 0.8 3 1023 mm2/sec 6 0.1, and 0.5 3 1023 mm2/sec 6 0.1 for grade 2; and 3.7% 6 0.3, 0.9 3 1023 mm2/sec 6 0.1, and 0.5 3 1023 mm2/sec 6 0.1 for grade 3, respectively. The APT SIs of grade 3 EEA were significantly higher than those of grade 1 EEA (P = .01), but other pairwise comparisons did not reveal any significant differences (P = .06-.51). The mean and minimum ADCs showed no significant differences among the three histologic grades (P =.13-.51). Conclusion: The APT SI was positively correlated with the histologic grades of EEA.

AB - Purpose: To evaluate the utility of amide proton transfer (APT) imaging in estimating histologic grades of endometrioid endometrial adenocarcinoma (EEA). Materials and The institutional review board approved this prospective Methods: study. Between June 2012 and March 2016, 32 patients with EEA underwent magnetic resonance (MR) imaging. After their surgical procedures, their EEAs were confirmed pathologically and classified into histologic grades: grade 1 (n = 11), grade 2 (n = 11), and grade 3 (n = 10). The APT signal intensities (SIs) and the mean and minimum apparent diffusion coefficients (ADCs) of the three grades were calculated and compared. Spearman rank correlation coefficient was also calculated between the APT SIs and histologic grades, and between the ADCs and histologic grades. Results: The Spearman correlation coefficient with histologic grade of the APT SIs, the mean ADC, and the minimum ADC were 0.55 (P = .001), 0.03 (P = .84), and 20.30 (P = .09), respectively. The average APT SIs and the mean and minimum ADCs were 2.2% 6 0.2 (standard deviation), 0.9 3 1023 mm2/sec 6 0.2, and 0.6 3 1023 mm2/sec 6 0.1 for grade 1; 3.2% 6 0.3, 0.8 3 1023 mm2/sec 6 0.1, and 0.5 3 1023 mm2/sec 6 0.1 for grade 2; and 3.7% 6 0.3, 0.9 3 1023 mm2/sec 6 0.1, and 0.5 3 1023 mm2/sec 6 0.1 for grade 3, respectively. The APT SIs of grade 3 EEA were significantly higher than those of grade 1 EEA (P = .01), but other pairwise comparisons did not reveal any significant differences (P = .06-.51). The mean and minimum ADCs showed no significant differences among the three histologic grades (P =.13-.51). Conclusion: The APT SI was positively correlated with the histologic grades of EEA.

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