Amine modification reaction of C4'-oxidized abasic site generated from its caged precursors.

Kazuteru Usui, Mitsuhiro Fukuda, Mariko Aso, Hiroshi Suemune

Research output: Contribution to journalMeeting Abstract

Abstract

A method for the generation of ODNs containing a C4'-oxidized abasic site (C4'-OAS) from "photocaged" ODNs was investigated. We synthesized C4'-caged ODN 1 and C1'-caged ODN 2 bearing an o-nitrobenzyloxy group at the C-4' position and the C-1' position, respectively. The duplex stabilities of 1 and 2, with their complementary ODNs were studied by Tm measurements. The photochemical reaction of 1 and 2 to generate ODN 3 containing C4'-OAS, and the subsequent amine modification reaction were studied.

Original languageEnglish
Pages (from-to)191-192
Number of pages2
JournalNucleic acids symposium series (2004)
Issue number49
Publication statusPublished - 2005

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Fingerprint Dive into the research topics of 'Amine modification reaction of C4'-oxidized abasic site generated from its caged precursors.'. Together they form a unique fingerprint.

  • Cite this