Amino acid composition of soybean protein increased postprandial carbohydrate oxidation in diabetic mice

Kengo Ishihara, Yoshiko Fukuchi, Wataru Mizunoya, Yukiko Mita, Yoko Fukuya, Tohru Fushiki, Kyoden Yasumoto

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

The effects of an amino acid mixture simulating dietary soybean protein on the postprandial energy metabolism was investigated using type II diabetic mice. KK-Ay strain mice were fed restrictive isoenergetic and isonitrogenous diets (35% of energy as protein and 5% as fat) based on either casein, soybean protein isolate hydrolysate (SPI-H), SPI-HET (ethanol unsoluble fraction of SPI-H), SPI-AA and casein-AA (amino acid mixtures simulating SPI-H and casein). To measure dietary carbohydrate oxidation, the animals were fed a diet containing 13C-glucose. Postprandial respiratory quotient and expired 13CO2 were higher in the SPI-AA than in the casein-AA group, as the differences were similarly observed in mice fed SPI-H and casein diet. No significant differences were observed in the postprandial respiratory quotient and expired 13CO2 between the SPI-H and SPI-HET group. In conclusion, this study on food-restricted mice indicates that the amino acid mixtures simulating SPI-H or casein could affect postprandial energy metabolism in diabetic mice, as observed in those fed SPI-H or casein in the form of peptide or protein.

Original languageEnglish
Pages (from-to)2505-2511
Number of pages7
JournalBioscience, Biotechnology and Biochemistry
Volume67
Issue number12
DOIs
Publication statusPublished - Dec 1 2003

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Soybean Proteins
Protein Hydrolysates
soy protein
protein isolates
amino acid composition
Caseins
hydrolysates
casein
Carbohydrates
oxidation
carbohydrates
Amino Acids
Oxidation
mice
Chemical analysis
Nutrition
respiratory quotient
Diet
energy metabolism
Energy Metabolism

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Analytical Chemistry
  • Biochemistry
  • Applied Microbiology and Biotechnology
  • Molecular Biology
  • Organic Chemistry

Cite this

Ishihara, K., Fukuchi, Y., Mizunoya, W., Mita, Y., Fukuya, Y., Fushiki, T., & Yasumoto, K. (2003). Amino acid composition of soybean protein increased postprandial carbohydrate oxidation in diabetic mice. Bioscience, Biotechnology and Biochemistry, 67(12), 2505-2511. https://doi.org/10.1271/bbb.67.2505

Amino acid composition of soybean protein increased postprandial carbohydrate oxidation in diabetic mice. / Ishihara, Kengo; Fukuchi, Yoshiko; Mizunoya, Wataru; Mita, Yukiko; Fukuya, Yoko; Fushiki, Tohru; Yasumoto, Kyoden.

In: Bioscience, Biotechnology and Biochemistry, Vol. 67, No. 12, 01.12.2003, p. 2505-2511.

Research output: Contribution to journalArticle

Ishihara, K, Fukuchi, Y, Mizunoya, W, Mita, Y, Fukuya, Y, Fushiki, T & Yasumoto, K 2003, 'Amino acid composition of soybean protein increased postprandial carbohydrate oxidation in diabetic mice', Bioscience, Biotechnology and Biochemistry, vol. 67, no. 12, pp. 2505-2511. https://doi.org/10.1271/bbb.67.2505
Ishihara, Kengo ; Fukuchi, Yoshiko ; Mizunoya, Wataru ; Mita, Yukiko ; Fukuya, Yoko ; Fushiki, Tohru ; Yasumoto, Kyoden. / Amino acid composition of soybean protein increased postprandial carbohydrate oxidation in diabetic mice. In: Bioscience, Biotechnology and Biochemistry. 2003 ; Vol. 67, No. 12. pp. 2505-2511.
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