Amino acid composition of soybean protein increased postprandial carbohydrate oxidation in diabetic mice

Kengo Ishihara, Yoshiko Fukuchi, Wataru Mizunoya, Yukiko Mita, Yoko Fukuya, Tohru Fushiki, Kyoden Yasumoto

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

The effects of an amino acid mixture simulating dietary soybean protein on the postprandial energy metabolism was investigated using type II diabetic mice. KK-Ay strain mice were fed restrictive isoenergetic and isonitrogenous diets (35% of energy as protein and 5% as fat) based on either casein, soybean protein isolate hydrolysate (SPI-H), SPI-HET (ethanol unsoluble fraction of SPI-H), SPI-AA and casein-AA (amino acid mixtures simulating SPI-H and casein). To measure dietary carbohydrate oxidation, the animals were fed a diet containing 13C-glucose. Postprandial respiratory quotient and expired 13CO2 were higher in the SPI-AA than in the casein-AA group, as the differences were similarly observed in mice fed SPI-H and casein diet. No significant differences were observed in the postprandial respiratory quotient and expired 13CO2 between the SPI-H and SPI-HET group. In conclusion, this study on food-restricted mice indicates that the amino acid mixtures simulating SPI-H or casein could affect postprandial energy metabolism in diabetic mice, as observed in those fed SPI-H or casein in the form of peptide or protein.

Original languageEnglish
Pages (from-to)2505-2511
Number of pages7
JournalBioscience, Biotechnology and Biochemistry
Volume67
Issue number12
DOIs
Publication statusPublished - Dec 1 2003

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Analytical Chemistry
  • Biochemistry
  • Applied Microbiology and Biotechnology
  • Molecular Biology
  • Organic Chemistry

Fingerprint Dive into the research topics of 'Amino acid composition of soybean protein increased postprandial carbohydrate oxidation in diabetic mice'. Together they form a unique fingerprint.

  • Cite this

    Ishihara, K., Fukuchi, Y., Mizunoya, W., Mita, Y., Fukuya, Y., Fushiki, T., & Yasumoto, K. (2003). Amino acid composition of soybean protein increased postprandial carbohydrate oxidation in diabetic mice. Bioscience, Biotechnology and Biochemistry, 67(12), 2505-2511. https://doi.org/10.1271/bbb.67.2505