TY - JOUR
T1 - Amino acid composition of soybean protein increased postprandial carbohydrate oxidation in diabetic mice
AU - Ishihara, Kengo
AU - Fukuchi, Yoshiko
AU - Mizunoya, Wataru
AU - Mita, Yukiko
AU - Fukuya, Yoko
AU - Fushiki, Tohru
AU - Yasumoto, Kyoden
N1 - Funding Information:
We acknowledge the kind assistance of Miki Takahashi, Kikumi Segawa, Koichiro Ohnuki, Satoshi Haramizu, Akimori Hirayama, Tetsuro Shibakusa, and Yuki Okabe. This work was supported in part by the Fuji Foundation for Protein Research, Japan.
Copyright:
Copyright 2008 Elsevier B.V., All rights reserved.
PY - 2003/12
Y1 - 2003/12
N2 - The effects of an amino acid mixture simulating dietary soybean protein on the postprandial energy metabolism was investigated using type II diabetic mice. KK-Ay strain mice were fed restrictive isoenergetic and isonitrogenous diets (35% of energy as protein and 5% as fat) based on either casein, soybean protein isolate hydrolysate (SPI-H), SPI-HET (ethanol unsoluble fraction of SPI-H), SPI-AA and casein-AA (amino acid mixtures simulating SPI-H and casein). To measure dietary carbohydrate oxidation, the animals were fed a diet containing 13C-glucose. Postprandial respiratory quotient and expired 13CO2 were higher in the SPI-AA than in the casein-AA group, as the differences were similarly observed in mice fed SPI-H and casein diet. No significant differences were observed in the postprandial respiratory quotient and expired 13CO2 between the SPI-H and SPI-HET group. In conclusion, this study on food-restricted mice indicates that the amino acid mixtures simulating SPI-H or casein could affect postprandial energy metabolism in diabetic mice, as observed in those fed SPI-H or casein in the form of peptide or protein.
AB - The effects of an amino acid mixture simulating dietary soybean protein on the postprandial energy metabolism was investigated using type II diabetic mice. KK-Ay strain mice were fed restrictive isoenergetic and isonitrogenous diets (35% of energy as protein and 5% as fat) based on either casein, soybean protein isolate hydrolysate (SPI-H), SPI-HET (ethanol unsoluble fraction of SPI-H), SPI-AA and casein-AA (amino acid mixtures simulating SPI-H and casein). To measure dietary carbohydrate oxidation, the animals were fed a diet containing 13C-glucose. Postprandial respiratory quotient and expired 13CO2 were higher in the SPI-AA than in the casein-AA group, as the differences were similarly observed in mice fed SPI-H and casein diet. No significant differences were observed in the postprandial respiratory quotient and expired 13CO2 between the SPI-H and SPI-HET group. In conclusion, this study on food-restricted mice indicates that the amino acid mixtures simulating SPI-H or casein could affect postprandial energy metabolism in diabetic mice, as observed in those fed SPI-H or casein in the form of peptide or protein.
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U2 - 10.1271/bbb.67.2505
DO - 10.1271/bbb.67.2505
M3 - Article
C2 - 14730126
AN - SCOPUS:4544363739
SN - 0916-8451
VL - 67
SP - 2505
EP - 2511
JO - Bioscience, Biotechnology and Biochemistry
JF - Bioscience, Biotechnology and Biochemistry
IS - 12
ER -
