Amniotic fluid proteins in the antenatal diagnosis of some fetal abnormalities

Yumi Higa, Takehiko Sasazuki, Hiroshi Nakajima, Masaomi Takayama, Masaki Tada, Hiroaki Soma

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

This study has been performed in an attempt to find marker protein molecules in amniotic fluid or maternal serum which would indicate fetuses with certain abnormalities. Amniotic fluid from normal pregnancies and those which lead to Down's syndrome, anencephaly, and intrauterine fetal death at different stages of pregnancy and delivery was subjected to quantitative and qualitative determination of protein constituents. The values of total protein, 19 protein components reactive to antihuman serum antisera, and α-fetoprotein in amniotic fluid as well as α-fetoprotein in maternal serum are shown for various stages of gestation. Among these, γM, γA, γG, and α-fetoprotein in amniotic fluid were assumed to be useful for the antenatal diagnosis of anencephaly and intrauterine fetal death. It was further demonstrated that α-fetoprotein in maternal serum shows a highly significant increase in these abnormalities, offering the possibility of antenatal diagnosis of other fetal distress through the monitoring of α-fetoprotein levels in maternal serum.

Original languageEnglish
Pages (from-to)932-938
Number of pages7
JournalAmerican Journal of Obstetrics and Gynecology
Volume119
Issue number7
DOIs
Publication statusPublished - Aug 1 1974
Externally publishedYes

Fingerprint

Fetal Proteins
Amniotic Fluid
Prenatal Diagnosis
Mothers
Anencephaly
Serum
Fetal Death
Proteins
Pregnancy
Fetal Distress
Down Syndrome
Immune Sera
Fetus

All Science Journal Classification (ASJC) codes

  • Obstetrics and Gynaecology

Cite this

Amniotic fluid proteins in the antenatal diagnosis of some fetal abnormalities. / Higa, Yumi; Sasazuki, Takehiko; Nakajima, Hiroshi; Takayama, Masaomi; Tada, Masaki; Soma, Hiroaki.

In: American Journal of Obstetrics and Gynecology, Vol. 119, No. 7, 01.08.1974, p. 932-938.

Research output: Contribution to journalArticle

Higa, Yumi ; Sasazuki, Takehiko ; Nakajima, Hiroshi ; Takayama, Masaomi ; Tada, Masaki ; Soma, Hiroaki. / Amniotic fluid proteins in the antenatal diagnosis of some fetal abnormalities. In: American Journal of Obstetrics and Gynecology. 1974 ; Vol. 119, No. 7. pp. 932-938.
@article{04ad5c2beea142c29151b694c252e89c,
title = "Amniotic fluid proteins in the antenatal diagnosis of some fetal abnormalities",
abstract = "This study has been performed in an attempt to find marker protein molecules in amniotic fluid or maternal serum which would indicate fetuses with certain abnormalities. Amniotic fluid from normal pregnancies and those which lead to Down's syndrome, anencephaly, and intrauterine fetal death at different stages of pregnancy and delivery was subjected to quantitative and qualitative determination of protein constituents. The values of total protein, 19 protein components reactive to antihuman serum antisera, and α-fetoprotein in amniotic fluid as well as α-fetoprotein in maternal serum are shown for various stages of gestation. Among these, γM, γA, γG, and α-fetoprotein in amniotic fluid were assumed to be useful for the antenatal diagnosis of anencephaly and intrauterine fetal death. It was further demonstrated that α-fetoprotein in maternal serum shows a highly significant increase in these abnormalities, offering the possibility of antenatal diagnosis of other fetal distress through the monitoring of α-fetoprotein levels in maternal serum.",
author = "Yumi Higa and Takehiko Sasazuki and Hiroshi Nakajima and Masaomi Takayama and Masaki Tada and Hiroaki Soma",
year = "1974",
month = "8",
day = "1",
doi = "10.1016/0002-9378(74)90010-6",
language = "English",
volume = "119",
pages = "932--938",
journal = "American Journal of Obstetrics and Gynecology",
issn = "0002-9378",
publisher = "Mosby Inc.",
number = "7",

}

TY - JOUR

T1 - Amniotic fluid proteins in the antenatal diagnosis of some fetal abnormalities

AU - Higa, Yumi

AU - Sasazuki, Takehiko

AU - Nakajima, Hiroshi

AU - Takayama, Masaomi

AU - Tada, Masaki

AU - Soma, Hiroaki

PY - 1974/8/1

Y1 - 1974/8/1

N2 - This study has been performed in an attempt to find marker protein molecules in amniotic fluid or maternal serum which would indicate fetuses with certain abnormalities. Amniotic fluid from normal pregnancies and those which lead to Down's syndrome, anencephaly, and intrauterine fetal death at different stages of pregnancy and delivery was subjected to quantitative and qualitative determination of protein constituents. The values of total protein, 19 protein components reactive to antihuman serum antisera, and α-fetoprotein in amniotic fluid as well as α-fetoprotein in maternal serum are shown for various stages of gestation. Among these, γM, γA, γG, and α-fetoprotein in amniotic fluid were assumed to be useful for the antenatal diagnosis of anencephaly and intrauterine fetal death. It was further demonstrated that α-fetoprotein in maternal serum shows a highly significant increase in these abnormalities, offering the possibility of antenatal diagnosis of other fetal distress through the monitoring of α-fetoprotein levels in maternal serum.

AB - This study has been performed in an attempt to find marker protein molecules in amniotic fluid or maternal serum which would indicate fetuses with certain abnormalities. Amniotic fluid from normal pregnancies and those which lead to Down's syndrome, anencephaly, and intrauterine fetal death at different stages of pregnancy and delivery was subjected to quantitative and qualitative determination of protein constituents. The values of total protein, 19 protein components reactive to antihuman serum antisera, and α-fetoprotein in amniotic fluid as well as α-fetoprotein in maternal serum are shown for various stages of gestation. Among these, γM, γA, γG, and α-fetoprotein in amniotic fluid were assumed to be useful for the antenatal diagnosis of anencephaly and intrauterine fetal death. It was further demonstrated that α-fetoprotein in maternal serum shows a highly significant increase in these abnormalities, offering the possibility of antenatal diagnosis of other fetal distress through the monitoring of α-fetoprotein levels in maternal serum.

UR - http://www.scopus.com/inward/record.url?scp=0016137343&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0016137343&partnerID=8YFLogxK

U2 - 10.1016/0002-9378(74)90010-6

DO - 10.1016/0002-9378(74)90010-6

M3 - Article

C2 - 4276312

AN - SCOPUS:0016137343

VL - 119

SP - 932

EP - 938

JO - American Journal of Obstetrics and Gynecology

JF - American Journal of Obstetrics and Gynecology

SN - 0002-9378

IS - 7

ER -