Amphotericin B covalent dimers with carbonyl-amino linkage: a new probe for investigating ion channel assemblies

Yuichi Umegawa, Nobuaki Matsumori, Tohru Oishi, Michio Murata

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Based on an amphotericin B (AmB) ion-channel model where the close proximity of neighboring molecules is effected by interaction between carboxyl and amino groups, we prepared covalent dimers of AmB connected between these functionalities. While directly connected and short-tethered derivatives (2 and 3) lacked the activities, dimer 4 with a longer linker revealed K+ ion flux activity, suggesting that some distance and/or flexibility between the carboxyl and amino groups in adjacent molecules is required for the formation of ion-permeable complex in biomembranes.

Original languageEnglish
Pages (from-to)3393-3396
Number of pages4
JournalTetrahedron Letters
Volume48
Issue number19
DOIs
Publication statusPublished - May 7 2007
Externally publishedYes

Fingerprint

Amphotericin B
Ion Channels
Dimers
Ions
Molecules
Fluxes
Derivatives

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

Cite this

Amphotericin B covalent dimers with carbonyl-amino linkage : a new probe for investigating ion channel assemblies. / Umegawa, Yuichi; Matsumori, Nobuaki; Oishi, Tohru; Murata, Michio.

In: Tetrahedron Letters, Vol. 48, No. 19, 07.05.2007, p. 3393-3396.

Research output: Contribution to journalArticle

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