Amphotericin B-phospholipid covalent conjugates: Dependence of membrane-permeabilizing activity on acyl-chain length

Shigeru Matsuoka, Nobuaki Matsumori, Michio Murata

Research output: Contribution to journalArticlepeer-review

27 Citations (Scopus)

Abstract

The interaction between amphotericin B and phospholipid upon forming ion channels across a biomembrane was investigated using their covalent conjugates. The membrane permeabilizing activity was greatly affected by the chain length of the fatty acyl groups, suggesting that their interaction is involved in ion channel assemblages.

Original languageEnglish
Pages (from-to)3882-3884
Number of pages3
JournalOrganic and Biomolecular Chemistry
Volume1
Issue number22
DOIs
Publication statusPublished - Nov 21 2003
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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