Amygdala-centred functional connectivity affects daily cortisol concentrations: A putative link with anxiety

Yuko Hakamata, Shotaro Komi, Yoshiya Moriguchi, Shuhei Izawa, Yuki Motomura, Eisuke Sato, Shinya Mizukami, Yoshiharu Kim, Takashi Hanakawa, Yusuke Inoue, Hirokuni Tagaya

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

The amygdala plays a critical role in emotion. Its functional coupling with the hippocampus and ventromedial prefrontal cortex extending to a portion of the anterior cingulate cortex (ACC) is implicated in anxiogenesis and hypothalamic-pituitary-adrenal (HPA) system regulation. However, it remains unclear how amygdala-centred functional connectivity (FC) affects anxiety and cortisol concentrations in everyday life. Here, we investigate the relationship between daily cortisol concentrations (dCOR) and amygdala-centred FC during emotional processing in forty-one healthy humans. FC analyses revealed that higher dCOR predicted strengthened amygdala-centred FC with the hippocampus and cerebellum, but inhibited FC with the supramarginal gyrus and a perigenual part of the ACC (pgACC) when processing fearful faces (vs. neutral faces). Notably, the strength of amygdala-hippocampus FC mediated the positive relationship between cortisol and anxiety, specifically when the effect of amygdala-pgACC FC, a presumptive neural indicator of emotional control, was taken into account. Individuals with diminished connectivity between the amygdala and pgACC during fear-related processing might be more vulnerable to anxiogenesis as it pertains to greater circulating cortisol levels in everyday life. Individual functional patterns of amygdala-hippocampal-pgACC connectivity might provide a key to understand the complicate link between cortisol and anxiety-related behaviors.

Original languageEnglish
Article number8313
JournalScientific reports
Volume7
Issue number1
DOIs
Publication statusPublished - Dec 1 2017

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Amygdala
Hydrocortisone
Anxiety
Hippocampus
Gyrus Cinguli
Pituitary-Adrenal System
Parietal Lobe
Prefrontal Cortex
Cerebellum
Fear
Emotions

All Science Journal Classification (ASJC) codes

  • General

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Amygdala-centred functional connectivity affects daily cortisol concentrations : A putative link with anxiety. / Hakamata, Yuko; Komi, Shotaro; Moriguchi, Yoshiya; Izawa, Shuhei; Motomura, Yuki; Sato, Eisuke; Mizukami, Shinya; Kim, Yoshiharu; Hanakawa, Takashi; Inoue, Yusuke; Tagaya, Hirokuni.

In: Scientific reports, Vol. 7, No. 1, 8313, 01.12.2017.

Research output: Contribution to journalArticle

Hakamata, Y, Komi, S, Moriguchi, Y, Izawa, S, Motomura, Y, Sato, E, Mizukami, S, Kim, Y, Hanakawa, T, Inoue, Y & Tagaya, H 2017, 'Amygdala-centred functional connectivity affects daily cortisol concentrations: A putative link with anxiety', Scientific reports, vol. 7, no. 1, 8313. https://doi.org/10.1038/s41598-017-08918-7
Hakamata, Yuko ; Komi, Shotaro ; Moriguchi, Yoshiya ; Izawa, Shuhei ; Motomura, Yuki ; Sato, Eisuke ; Mizukami, Shinya ; Kim, Yoshiharu ; Hanakawa, Takashi ; Inoue, Yusuke ; Tagaya, Hirokuni. / Amygdala-centred functional connectivity affects daily cortisol concentrations : A putative link with anxiety. In: Scientific reports. 2017 ; Vol. 7, No. 1.
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