Amyloid β-protein gene duplication is not common in Alzheimer's disease: Analysis by polymorphic restriction fragments

Hirokazu Furuya, Hiroyuki Sasaki, Ikuo Goto, Caine W. Wong, George G. Glenner, Yoshiyuki Sakaki

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The amyloid β-protein(BP) is an important component of amyloid fibrils of both Alzheimer's disease(AD) and adult Down syndrome(DS). It has been hypothesized that sporadic AD may involve the duplication of a subregion of chromosome 21 containing the BP locus. However, an improved method for detection of the BP gene duplication using polymorphic Hind III fragments led us to a conclusion that BP gene duplication is rare, if any, in (Japanese) sporadic AD patients, indicating that the duplication of the BP gene itself is not the common underlying genetic defect in AD.

Original languageEnglish
Pages (from-to)75-81
Number of pages7
JournalBiochemical and Biophysical Research Communications
Issue number1
Publication statusPublished - Jan 15 1988


All Science Journal Classification (ASJC) codes

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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