TY - JOUR
T1 - An α-glucosidase inhibitor, voglibose, reduces oxidative stress markers and soluble intercellular adhesion molecule 1 in obese type 2 diabetic patients
AU - Satoh, Noriko
AU - Shimatsu, Akira
AU - Yamada, Kazunori
AU - Aizawa-Abe, Megumi
AU - Suganami, Takayoshi
AU - Kuzuya, Hideshi
AU - Ogawa, Yoshihiro
N1 - Funding Information:
This work was supported in part by a Grant-in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science, and Technology of Japan, and research grants from ONO Medical Foundation and Takeda Science Foundation (to YO), and Research Grant for Cardiovascular Diseases (16C-2) from the Ministry of Health, Labor and Welfare, Smoking Research Foundation, and Japan Heart Foundation/Pfizer Grant for Research on Hyperlipidemia and Vascular Metabolism (to NS).
PY - 2006/6
Y1 - 2006/6
N2 - Postprandial hyperglycemia and hyperlipidemia are considered risk factors for cardiovascular disease. This study was designed to elucidate whether improving the postprandial state by voglibose, an α-glucosidase inhibitor, leads to the reduction of oxidative stress markers and soluble adhesion molecules in obese type 2 diabetic patients. A total of 30 Japanese obese type 2 diabetic patients were randomly assigned and treated for 3 weeks with either diet alone (the control group) or diet plus voglibose (0.9 mg daily) (the voglibose group) (n = 15 each). Analysis of the diurnal metabolic profiles revealed a significant reduction of postprandial hyperglycemia and hyperlipidemia in the voglibose group relative to the control group (P < .05), despite the similar improvement in body mass index and hemoglobin A1c in both groups. Voglibose also decreased significantly the plasma levels of soluble intercellular adhesion molecule 1 and urinary excretion of 8-iso-prostaglandin F2α and 8-hydroxydeoxyguanosine (P < .01) and C-reactive protein (P < .05) relative to the control group. In conclusion, this study represents the first demonstration that voglibose reduces oxidative stress generation and soluble intercellular adhesion molecule 1 in parallel with the reduction of postprandial hyperglycemia and hyperlipidemia in obese type 2 diabetic patients.
AB - Postprandial hyperglycemia and hyperlipidemia are considered risk factors for cardiovascular disease. This study was designed to elucidate whether improving the postprandial state by voglibose, an α-glucosidase inhibitor, leads to the reduction of oxidative stress markers and soluble adhesion molecules in obese type 2 diabetic patients. A total of 30 Japanese obese type 2 diabetic patients were randomly assigned and treated for 3 weeks with either diet alone (the control group) or diet plus voglibose (0.9 mg daily) (the voglibose group) (n = 15 each). Analysis of the diurnal metabolic profiles revealed a significant reduction of postprandial hyperglycemia and hyperlipidemia in the voglibose group relative to the control group (P < .05), despite the similar improvement in body mass index and hemoglobin A1c in both groups. Voglibose also decreased significantly the plasma levels of soluble intercellular adhesion molecule 1 and urinary excretion of 8-iso-prostaglandin F2α and 8-hydroxydeoxyguanosine (P < .01) and C-reactive protein (P < .05) relative to the control group. In conclusion, this study represents the first demonstration that voglibose reduces oxidative stress generation and soluble intercellular adhesion molecule 1 in parallel with the reduction of postprandial hyperglycemia and hyperlipidemia in obese type 2 diabetic patients.
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U2 - 10.1016/j.metabol.2006.01.016
DO - 10.1016/j.metabol.2006.01.016
M3 - Article
C2 - 16713439
AN - SCOPUS:33646518771
SN - 0026-0495
VL - 55
SP - 786
EP - 793
JO - Metabolism: Clinical and Experimental
JF - Metabolism: Clinical and Experimental
IS - 6
ER -
