An adolescent female having hepatocellular carcinoma associated with hepatitis B virus genotype H with a deletion mutation in the pre-S2 region

Utako Oba, Yuhki Koga, Takayuki Hoshina, Aiko Suminoe, Kenji Abe, Makoto Hayashida, Tomoaki Taguchi, Toshiro Hara

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The genotypes of hepatitis B virus (HBV) have a distinct geographical distribution, with HBV genotype H being very rare in East Asia, including Japan. We herein report the case of a 12-year-old Japanese female with hepatocellular carcinoma (HCC) who exhibited HBV genotype H. Notably, the HBV isolated from the patient had a deletion mutation in the pre-S2 region. The genome of HBV genotype H in the patient with HCC has not been analyzed in detail. The deletion mutations in the pre-S2 region, which may play an important role in hepatocarcinogenesis in children, can also present in genotype H.

Original languageEnglish
Pages (from-to)302-304
Number of pages3
JournalJournal of Infection and Chemotherapy
Volume21
Issue number4
DOIs
Publication statusPublished - Apr 1 2015

All Science Journal Classification (ASJC) codes

  • Microbiology (medical)
  • Pharmacology (medical)
  • Infectious Diseases

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