An advanced case of indium lung disease with progressive emphysema

Makiko Nakano, Akiyo Tanaka, Miyuki Hirata, Hiroyuki Kumazoe, Kentaro Wakamatsu, Dan Kamada, Kazuyuki Omae

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Objectives: To report the occurrence of an advanced case of indium lung disease with severely progressive emphysema in an indium-exposed worker. Case report: A healthy 42-year-old male smoker was employed to primarily grind indium-tin oxide (ITO) target plates, exposing him to indium for 9 years (1998-2008). In 2004, an epidemiological study was conducted on indium-exposed workers at the factory in which he worked. The subject's serum indium concentration (In-S) was 99.7 μg/l, while his serum Krebs von den Lungen-6 level was 2,350 U/ml. Pulmonary function tests showed forced vital capacity (FVC) of 4.17 l (91.5% of the JRS predicted value), forced expiratory volume in 1 s (FEV1) of 3.19 l (80.8% of predicted), and an FEV1-to-FVC ratio of 76.5%. A high-resolution chest computed tomography (HRCT) scan showed mild interlobular septal thickening and mild emphysematous changes. In 2008, he was transferred from the ITO grinding workplace to an inspection work section, where indium concentrations in total dusts had a range of 0.001-0.002 mg/m3. In 2009, the subject's In-S had increased to 132.1 μg / l, and pulmonary function tests revealed obstructive changes. In addition, HRCT scan showed clear evidence of progressive lung destruction with accompanying severe centrilobular emphysema and interlobular septal thickening in both lung fields. The subject's condition gradually worsened, and in 2015, he was registered with the Japan Organ Transplant Network for lung transplantation (LTx). Conclusions: Heavy indium exposure is a risk factor for emphysema, which can lead to a severity level that requires LTx as the final therapeutic option.

Original languageEnglish
Pages (from-to)477-481
Number of pages5
JournalJournal of Occupational Health
Volume58
Issue number5
DOIs
Publication statusPublished - Jan 1 2016

Fingerprint

Indium
Emphysema
Lung Diseases
Respiratory Function Tests
Vital Capacity
Forced Expiratory Volume
Thorax
Tomography
Lung
Pulmonary Emphysema
Lung Transplantation
Dust
Serum
Workplace
Epidemiologic Studies
Japan
Transplants

All Science Journal Classification (ASJC) codes

  • Public Health, Environmental and Occupational Health

Cite this

An advanced case of indium lung disease with progressive emphysema. / Nakano, Makiko; Tanaka, Akiyo; Hirata, Miyuki; Kumazoe, Hiroyuki; Wakamatsu, Kentaro; Kamada, Dan; Omae, Kazuyuki.

In: Journal of Occupational Health, Vol. 58, No. 5, 01.01.2016, p. 477-481.

Research output: Contribution to journalArticle

Nakano, Makiko ; Tanaka, Akiyo ; Hirata, Miyuki ; Kumazoe, Hiroyuki ; Wakamatsu, Kentaro ; Kamada, Dan ; Omae, Kazuyuki. / An advanced case of indium lung disease with progressive emphysema. In: Journal of Occupational Health. 2016 ; Vol. 58, No. 5. pp. 477-481.
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abstract = "Objectives: To report the occurrence of an advanced case of indium lung disease with severely progressive emphysema in an indium-exposed worker. Case report: A healthy 42-year-old male smoker was employed to primarily grind indium-tin oxide (ITO) target plates, exposing him to indium for 9 years (1998-2008). In 2004, an epidemiological study was conducted on indium-exposed workers at the factory in which he worked. The subject's serum indium concentration (In-S) was 99.7 μg/l, while his serum Krebs von den Lungen-6 level was 2,350 U/ml. Pulmonary function tests showed forced vital capacity (FVC) of 4.17 l (91.5{\%} of the JRS predicted value), forced expiratory volume in 1 s (FEV1) of 3.19 l (80.8{\%} of predicted), and an FEV1-to-FVC ratio of 76.5{\%}. A high-resolution chest computed tomography (HRCT) scan showed mild interlobular septal thickening and mild emphysematous changes. In 2008, he was transferred from the ITO grinding workplace to an inspection work section, where indium concentrations in total dusts had a range of 0.001-0.002 mg/m3. In 2009, the subject's In-S had increased to 132.1 μg / l, and pulmonary function tests revealed obstructive changes. In addition, HRCT scan showed clear evidence of progressive lung destruction with accompanying severe centrilobular emphysema and interlobular septal thickening in both lung fields. The subject's condition gradually worsened, and in 2015, he was registered with the Japan Organ Transplant Network for lung transplantation (LTx). Conclusions: Heavy indium exposure is a risk factor for emphysema, which can lead to a severity level that requires LTx as the final therapeutic option.",
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