An air-stable chiral Hf-based catalyst for asymmetric Mannich-type reactions

Shu Kobayashi; Ryo Yazaki; Kazutaka Seki; Masaharu Ueno

doi:10.1016/j.tet.2007.05.115

An air-stable chiral Hf-based catalyst for asymmetric Mannich-type reactions

Shu Kobayashi, Ryo Yazaki, Kazutaka Seki, Masaharu Ueno

Research output: Contribution to journal › Article › peer-review

14 Citations (Scopus)

Abstract

A new class of isolable, air-stable, storable, and Hf-based catalyst has been developed. In the presence of 10 mol % of the powdered Hf catalyst, the asymmetric Mannich-type reactions of imines with silicon enolates derived from esters proceeded smoothly to afford the corresponding Mannich-type adducts in high yields with high enantioselectivities. Hafnium single crystals for X-ray analysis were obtained, and the crystals also showed high performance in the asymmetric Mannich-type reactions.

Original language	English
Pages (from-to)	8425-8429
Number of pages	5
Journal	Tetrahedron
Volume	63
Issue number	35
DOIs	https://doi.org/10.1016/j.tet.2007.05.115
Publication status	Published - Aug 27 2007
Externally published	Yes

All Science Journal Classification (ASJC) codes

Biochemistry
Drug Discovery
Organic Chemistry

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10.1016/j.tet.2007.05.115

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author = "Shu Kobayashi and Ryo Yazaki and Kazutaka Seki and Masaharu Ueno",

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AU - Kobayashi, Shu

AU - Yazaki, Ryo

AU - Seki, Kazutaka

AU - Ueno, Masaharu

PY - 2007/8/27

Y1 - 2007/8/27

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AB - A new class of isolable, air-stable, storable, and Hf-based catalyst has been developed. In the presence of 10 mol % of the powdered Hf catalyst, the asymmetric Mannich-type reactions of imines with silicon enolates derived from esters proceeded smoothly to afford the corresponding Mannich-type adducts in high yields with high enantioselectivities. Hafnium single crystals for X-ray analysis were obtained, and the crystals also showed high performance in the asymmetric Mannich-type reactions.

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SP - 8425

EP - 8429

JO - Tetrahedron

JF - Tetrahedron

IS - 35

ER -

An air-stable chiral Hf-based catalyst for asymmetric Mannich-type reactions

Abstract

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