An air-stable chiral Hf-based catalyst for asymmetric Mannich-type reactions

Shu Kobayashi, Ryo Yazaki, Kazutaka Seki, Masaharu Ueno

Research output: Contribution to journalArticlepeer-review

19 Citations (Scopus)

Abstract

A new class of isolable, air-stable, storable, and Hf-based catalyst has been developed. In the presence of 10 mol % of the powdered Hf catalyst, the asymmetric Mannich-type reactions of imines with silicon enolates derived from esters proceeded smoothly to afford the corresponding Mannich-type adducts in high yields with high enantioselectivities. Hafnium single crystals for X-ray analysis were obtained, and the crystals also showed high performance in the asymmetric Mannich-type reactions.

Original languageEnglish
Pages (from-to)8425-8429
Number of pages5
JournalTetrahedron
Volume63
Issue number35
DOIs
Publication statusPublished - Aug 27 2007
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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