An algebraic-numeric algorithm for the model selection in kinetic networks

Hiroshi Yoshida, Koji Nakagawa, Hirokazu Anai, Katsuhisa Horimoto

Research output: Chapter in Book/Report/Conference proceedingConference contribution

3 Citations (Scopus)

Abstract

We propose a novel algorithm to select a model that is consistent with the time series of observed data. In the first step, the kinetics for describing a biological phenomenon is expressed by a system of differential equations, assuming that the relationships between the variables are linear. Simultaneously, the time series of the data are numerically fitted as a series of exponentials. In the next step, both the system of differential equations with the kinetic parameters and the series of exponentials fitted to the observed data are transformed into the corresponding system of algebraic equations, by the Laplace transformation. Finally, the two systems of algebraic equations are compared by an algebraic approach. The present method estimates the model's consistency with the observed data and the determined kinetic parameters. One of the merits of the present method is that it allows a kinetic model with cyclic relationships between variables that cannot be handled by the usual approaches. The plausibility of the present method is illustrated by the actual relationships between specific leaf area, leaf nitrogen and leaf gas exchange with the corresponding simulated data.

Original languageEnglish
Title of host publicationComputer Algebra in Scientific Computing - 10th International Workshop, CASC 2007, Proceedings
Pages433-447
Number of pages15
Publication statusPublished - Dec 1 2007
Event10th International Workshop Computer Algebra in Scientific Computing, CASC 2007 - Bonn, Germany
Duration: Sep 16 2007Sep 20 2007

Publication series

NameLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Volume4770 LNCS
ISSN (Print)0302-9743
ISSN (Electronic)1611-3349

Other

Other10th International Workshop Computer Algebra in Scientific Computing, CASC 2007
CountryGermany
CityBonn
Period9/16/079/20/07

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All Science Journal Classification (ASJC) codes

  • Theoretical Computer Science
  • Computer Science(all)

Cite this

Yoshida, H., Nakagawa, K., Anai, H., & Horimoto, K. (2007). An algebraic-numeric algorithm for the model selection in kinetic networks. In Computer Algebra in Scientific Computing - 10th International Workshop, CASC 2007, Proceedings (pp. 433-447). (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics); Vol. 4770 LNCS).