機能性ディスペプシアと十二指腸粘膜バリア機能障害

Translated title of the contribution: An Altered Duodenal Function Associated with the Pathophysiology of Functional Dyspepsia

小森 圭司, 伊原 栄吉, 後藤 和人, 康 東天, 小川 佳宏

Research output: Contribution to journalArticlepeer-review

Abstract

<p>Functional dyspepsia (FD) is a functional gastrointestinal disorder characterized by heterogeneous symptoms thought to originate from the gastroduodenal region, including postprandial fullness, early satiety, epigastric pain, and epigastric burning, although it does not have any associated organic disease that explains its symptoms. The pathogenesis of FD remains unclear, but it has been shown that the gastric function is basically associated with the pathogenesis of FD, which is also linked to the brain function along with psychological factors, a relationship known as brain-gut correlation. Recently, attention has been focused on the involvement of the duodenal function in the pathogenesis of FD. We previously showed that the mucosal barrier function was impaired in FD patients by measuring the duodenal mucosal barrier function directly during esophagogastroduodenoscopy. We therefore believe that the altered duodenal mucosal barrier function plays a role in the pathogenesis of FD.</p>
Translated title of the contributionAn Altered Duodenal Function Associated with the Pathophysiology of Functional Dyspepsia
Original languageJapanese
Pages (from-to)7-13
Number of pages7
Journal日本臨床生理学会雑誌
Volume50
Issue number1
DOIs
Publication statusPublished - 2020

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