An approach to a synthesis of the host-specific toxins ak-toxin i and ii, starting from vitamin c as a chiral material

Hiroshi Irie, Jun'etsu Igarashi, Kohei Matsumoto, Yumi Yanagawa, Tadakazu Nakashima, Tamio Ueno, Hiroshi Fukami

    Research output: Contribution to journalArticlepeer-review

    9 Citations (Scopus)

    Abstract

    An approach to the synthesis of AK-toxin I and II starting from Vitamin C was investigated. During the course of the approach, the stereostructure of the trienoic acid part of the toxins were reveled to be 8(R),9(S)- or 8(S),9(R)-9,10-epoxy-9-methyl-8-hydroxy-2E,4Z,6E-decatrienoic acid.

    Original languageEnglish
    Pages (from-to)1313-1315
    Number of pages3
    JournalChemical and Pharmaceutical Bulletin
    Volume33
    Issue number3
    DOIs
    Publication statusPublished - 1985

    All Science Journal Classification (ASJC) codes

    • Chemistry(all)
    • Drug Discovery

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