An association between salivary gland disease and serological abnormalities in Sjogren's syndrome

Seiji Nakamura, Akiko Ikebe-Hiroki, Masanori Shinohara, Yukiko Ohyama, Takefumi Mouri, Masanori Sasaki, Kanemitsu Shirasuna, Kikuo Nomoto

Research output: Contribution to journalArticle

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Abstract

In the labial salivary glands (LSGs) of 16 primary and 18 secondary Sjogren's syndrome (SS) patients, infiltrating lymphocytes were histologically and immunohistochemically examined; also, the serum levels of rheumatoid factor, antinuclear antibodies, anti-DNA antibodies, anti-SS-A and anti-SS-B antibodies, and immunoglobulins (including IgG, IgM and IgA) were all assayed. An immunohistochemical analysis of the lymphocyte subsets in LSGs revealed that severe lymphocytic infiltration was frequently accompanied by marked B cell accumulation both in primary and secondary SS patients. Furthermore, local B cell accumulation was also closely associated with elevated levels of anti-SS-A and anti-SS-B antibodies and IgG, and this association was statistically significant in the group with primary SS but not in the group with secondary SS. Thus, local lymphocytic infiltration, especially B cell accumulation, in the salivary glands is suggested to be involved in serological abnormalities in primary SS, while complicated autoimmune diseases other than SS may also be involved in serological abnormalities in secondary SS.

Original languageEnglish
Pages (from-to)426-430
Number of pages5
JournalJournal of Oral Pathology and Medicine
Volume26
Issue number9
DOIs
Publication statusPublished - Jan 1 1997

Fingerprint

Salivary Gland Diseases
Sjogren's Syndrome
Salivary Glands
B-Lymphocytes
Antinuclear Antibodies
Lip
Immunoglobulin G
Antibodies
Rheumatoid Factor
Lymphocyte Subsets
Immunoglobulin A
Autoimmune Diseases
Immunoglobulin M

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine
  • Oral Surgery
  • Otorhinolaryngology
  • Cancer Research
  • Periodontics

Cite this

An association between salivary gland disease and serological abnormalities in Sjogren's syndrome. / Nakamura, Seiji; Ikebe-Hiroki, Akiko; Shinohara, Masanori; Ohyama, Yukiko; Mouri, Takefumi; Sasaki, Masanori; Shirasuna, Kanemitsu; Nomoto, Kikuo.

In: Journal of Oral Pathology and Medicine, Vol. 26, No. 9, 01.01.1997, p. 426-430.

Research output: Contribution to journalArticle

Nakamura, Seiji ; Ikebe-Hiroki, Akiko ; Shinohara, Masanori ; Ohyama, Yukiko ; Mouri, Takefumi ; Sasaki, Masanori ; Shirasuna, Kanemitsu ; Nomoto, Kikuo. / An association between salivary gland disease and serological abnormalities in Sjogren's syndrome. In: Journal of Oral Pathology and Medicine. 1997 ; Vol. 26, No. 9. pp. 426-430.
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