An association of human T-cell lymphotropic virus type I infection with vascular dementia

Jun-Ichi Kira, T. Hamada, Y. Kawano, M. Okayama, K. Yamasaki

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Subjects ranging in age from 50 to 89 years old, either with or without dementia were studied by both ELISA for anti-human T-cell lymphotropic virus type I (HTLV-I) gag 100-130 antibody and by cranial CT in order to clarify the relationship between HTLV-I infection and dementia. The frequency of anti-HTLV-I antibody was found to be significantly higher in the patients with dementia (24/130, 18.5%) than in those without dementia (11/139, 7.9%) (P=0.0169). Among the various types of dementia, HTLV-I seropositivity was found to be significantly associated with vascular dementia (11/48, 23%) (P=0.0087), but not with Alzheimer type dementia. In addition, HTLV-I seropositivity was also associated with Babinski sign, and the severity of cerebral infarction, ventricular dilatation and periventricular lucency on CT. The presence of HTLV-I therefore appears to be one of the risk factors for vascular dementia in HTLV-I endemic areas.

Original languageEnglish
Pages (from-to)305-309
Number of pages5
JournalActa Neurologica Scandinavica
Volume96
Issue number5
Publication statusPublished - 1997

Fingerprint

Vascular Dementia
Virus Diseases
T-Lymphocytes
Dementia
Viruses
Babinski's Reflex
Antibodies
Cerebral Infarction
Dilatation
Alzheimer Disease
Enzyme-Linked Immunosorbent Assay

All Science Journal Classification (ASJC) codes

  • Clinical Neurology
  • Neuroscience(all)

Cite this

An association of human T-cell lymphotropic virus type I infection with vascular dementia. / Kira, Jun-Ichi; Hamada, T.; Kawano, Y.; Okayama, M.; Yamasaki, K.

In: Acta Neurologica Scandinavica, Vol. 96, No. 5, 1997, p. 305-309.

Research output: Contribution to journalArticle

Kira, J-I, Hamada, T, Kawano, Y, Okayama, M & Yamasaki, K 1997, 'An association of human T-cell lymphotropic virus type I infection with vascular dementia', Acta Neurologica Scandinavica, vol. 96, no. 5, pp. 305-309.
Kira, Jun-Ichi ; Hamada, T. ; Kawano, Y. ; Okayama, M. ; Yamasaki, K. / An association of human T-cell lymphotropic virus type I infection with vascular dementia. In: Acta Neurologica Scandinavica. 1997 ; Vol. 96, No. 5. pp. 305-309.
@article{87968a258a56498d8dcdda42eec3f890,
title = "An association of human T-cell lymphotropic virus type I infection with vascular dementia",
abstract = "Subjects ranging in age from 50 to 89 years old, either with or without dementia were studied by both ELISA for anti-human T-cell lymphotropic virus type I (HTLV-I) gag 100-130 antibody and by cranial CT in order to clarify the relationship between HTLV-I infection and dementia. The frequency of anti-HTLV-I antibody was found to be significantly higher in the patients with dementia (24/130, 18.5{\%}) than in those without dementia (11/139, 7.9{\%}) (P=0.0169). Among the various types of dementia, HTLV-I seropositivity was found to be significantly associated with vascular dementia (11/48, 23{\%}) (P=0.0087), but not with Alzheimer type dementia. In addition, HTLV-I seropositivity was also associated with Babinski sign, and the severity of cerebral infarction, ventricular dilatation and periventricular lucency on CT. The presence of HTLV-I therefore appears to be one of the risk factors for vascular dementia in HTLV-I endemic areas.",
author = "Jun-Ichi Kira and T. Hamada and Y. Kawano and M. Okayama and K. Yamasaki",
year = "1997",
language = "English",
volume = "96",
pages = "305--309",
journal = "Acta Neurologica Scandinavica",
issn = "0001-6314",
publisher = "Wiley-Blackwell",
number = "5",

}

TY - JOUR

T1 - An association of human T-cell lymphotropic virus type I infection with vascular dementia

AU - Kira, Jun-Ichi

AU - Hamada, T.

AU - Kawano, Y.

AU - Okayama, M.

AU - Yamasaki, K.

PY - 1997

Y1 - 1997

N2 - Subjects ranging in age from 50 to 89 years old, either with or without dementia were studied by both ELISA for anti-human T-cell lymphotropic virus type I (HTLV-I) gag 100-130 antibody and by cranial CT in order to clarify the relationship between HTLV-I infection and dementia. The frequency of anti-HTLV-I antibody was found to be significantly higher in the patients with dementia (24/130, 18.5%) than in those without dementia (11/139, 7.9%) (P=0.0169). Among the various types of dementia, HTLV-I seropositivity was found to be significantly associated with vascular dementia (11/48, 23%) (P=0.0087), but not with Alzheimer type dementia. In addition, HTLV-I seropositivity was also associated with Babinski sign, and the severity of cerebral infarction, ventricular dilatation and periventricular lucency on CT. The presence of HTLV-I therefore appears to be one of the risk factors for vascular dementia in HTLV-I endemic areas.

AB - Subjects ranging in age from 50 to 89 years old, either with or without dementia were studied by both ELISA for anti-human T-cell lymphotropic virus type I (HTLV-I) gag 100-130 antibody and by cranial CT in order to clarify the relationship between HTLV-I infection and dementia. The frequency of anti-HTLV-I antibody was found to be significantly higher in the patients with dementia (24/130, 18.5%) than in those without dementia (11/139, 7.9%) (P=0.0169). Among the various types of dementia, HTLV-I seropositivity was found to be significantly associated with vascular dementia (11/48, 23%) (P=0.0087), but not with Alzheimer type dementia. In addition, HTLV-I seropositivity was also associated with Babinski sign, and the severity of cerebral infarction, ventricular dilatation and periventricular lucency on CT. The presence of HTLV-I therefore appears to be one of the risk factors for vascular dementia in HTLV-I endemic areas.

UR - http://www.scopus.com/inward/record.url?scp=0030728292&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030728292&partnerID=8YFLogxK

M3 - Article

C2 - 9405000

AN - SCOPUS:0030728292

VL - 96

SP - 305

EP - 309

JO - Acta Neurologica Scandinavica

JF - Acta Neurologica Scandinavica

SN - 0001-6314

IS - 5

ER -