An astroblastoma case associated with loss of heterozygosity on chromosome 9p

Nobuhiro Hata; Tadahisa Shono; Koji Yoshimoto; Masahiro Mizoguchi; Tadao Kawamura; Shinji Nagata; Kenichi Matsumoto; Kenshi Hayashi; Toru Iwaki; Tomio Sasaki

doi:10.1007/s11060-006-9157-6

An astroblastoma case associated with loss of heterozygosity on chromosome 9p

Nobuhiro Hata, Tadahisa Shono, Koji Yoshimoto, Masahiro Mizoguchi, Tadao Kawamura, Shinji Nagata, Kenichi Matsumoto, Kenshi Hayashi, Toru Iwaki, Tomio Sasaki

Research output: Contribution to journal › Article

10 Citations (Scopus)

Abstract

The tumorigenesis of astroblastomas has not yet been elucidated on the basis of histopathological studies, and genetic studies may be useful for obtaining additional information regarding the tumorigenesis of these tumors. Here, we report an astroblastoma case in which a genetic analysis was performed. A 16-year-old female with a progressive headache was found to have a demarcated cystic tumor with a mural nodule in the right parietal lobe. Total removal of the tumor was achieved and a histological examination verified that the tumor was an astroblastoma. A genetic analysis using microsatellite markers revealed loss of heterozygosity (LOH) on chromosome 9p. The postoperative course was uneventful and, to date, she has been followed up for 2 years with no signs of recurrence. This is the first reported case of an astroblastoma in which LOH was detected on 9p. Based on this result, the tumorigenesis of astroblastomas is discussed.

Original language	English
Pages (from-to)	69-73
Number of pages	5
Journal	Journal of Neuro-Oncology
Volume	80
Issue number	1
DOIs	https://doi.org/10.1007/s11060-006-9157-6
Publication status	Published - Oct 1 2006

All Science Journal Classification (ASJC) codes

Oncology
Neurology
Clinical Neurology
Cancer Research

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Hata, N., Shono, T., Yoshimoto, K., Mizoguchi, M., Kawamura, T., Nagata, S., Matsumoto, K., Hayashi, K., Iwaki, T., & Sasaki, T. (2006). An astroblastoma case associated with loss of heterozygosity on chromosome 9p. Journal of Neuro-Oncology, 80(1), 69-73. https://doi.org/10.1007/s11060-006-9157-6

An astroblastoma case associated with loss of heterozygosity on chromosome 9p. / Hata, Nobuhiro; Shono, Tadahisa; Yoshimoto, Koji; Mizoguchi, Masahiro; Kawamura, Tadao; Nagata, Shinji; Matsumoto, Kenichi; Hayashi, Kenshi; Iwaki, Toru; Sasaki, Tomio.

In: Journal of Neuro-Oncology, Vol. 80, No. 1, 01.10.2006, p. 69-73.

Research output: Contribution to journal › Article

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abstract = "The tumorigenesis of astroblastomas has not yet been elucidated on the basis of histopathological studies, and genetic studies may be useful for obtaining additional information regarding the tumorigenesis of these tumors. Here, we report an astroblastoma case in which a genetic analysis was performed. A 16-year-old female with a progressive headache was found to have a demarcated cystic tumor with a mural nodule in the right parietal lobe. Total removal of the tumor was achieved and a histological examination verified that the tumor was an astroblastoma. A genetic analysis using microsatellite markers revealed loss of heterozygosity (LOH) on chromosome 9p. The postoperative course was uneventful and, to date, she has been followed up for 2 years with no signs of recurrence. This is the first reported case of an astroblastoma in which LOH was detected on 9p. Based on this result, the tumorigenesis of astroblastomas is discussed.",

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