An atomic force microscopy assay of intercalation binding, unwinding, and elongation of DNA, using a water-soluble psoralen derivative as a covalent binding probe molecule

Koji Nakano, Yosuke Katsumi, Nobuaki Soh, Toshihiko Imato

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

A single-molecule strategy using atomic force microscopy has simply yet robustly probed an intercalation binding related specific structural relaxation of covalently closed circular pBR322 DNA as well as double-strand elongation in its linear form by taking advantage of a new psoralen derivative, N,N,N-trimethyl-1-(2,5,9-trimethyl-7-oxo-7Hfuro[3,2-g]chromen-3-yl) methanaminium chloride, that covalently binds to DNA through a photo-crosslinking reaction.

Original languageEnglish
Pages (from-to)273-275
Number of pages3
JournalBulletin of the Chemical Society of Japan
Volume83
Issue number3
DOIs
Publication statusPublished - Mar 23 2010

All Science Journal Classification (ASJC) codes

  • Chemistry(all)

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