Abstract
A single-molecule strategy using atomic force microscopy has simply yet robustly probed an intercalation binding related specific structural relaxation of covalently closed circular pBR322 DNA as well as double-strand elongation in its linear form by taking advantage of a new psoralen derivative, N,N,N-trimethyl-1-(2,5,9-trimethyl-7-oxo-7Hfuro[3,2-g]chromen-3-yl) methanaminium chloride, that covalently binds to DNA through a photo-crosslinking reaction.
| Original language | English |
|---|---|
| Pages (from-to) | 273-275 |
| Number of pages | 3 |
| Journal | Bulletin of the Chemical Society of Japan |
| Volume | 83 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - Mar 23 2010 |
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All Science Journal Classification (ASJC) codes
- Chemistry(all)
Cite this
An atomic force microscopy assay of intercalation binding, unwinding, and elongation of DNA, using a water-soluble psoralen derivative as a covalent binding probe molecule. / Nakano, Koji; Katsumi, Yosuke; Soh, Nobuaki; Imato, Toshihiko.
In: Bulletin of the Chemical Society of Japan, Vol. 83, No. 3, 23.03.2010, p. 273-275.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - An atomic force microscopy assay of intercalation binding, unwinding, and elongation of DNA, using a water-soluble psoralen derivative as a covalent binding probe molecule
AU - Nakano, Koji
AU - Katsumi, Yosuke
AU - Soh, Nobuaki
AU - Imato, Toshihiko
PY - 2010/3/23
Y1 - 2010/3/23
N2 - A single-molecule strategy using atomic force microscopy has simply yet robustly probed an intercalation binding related specific structural relaxation of covalently closed circular pBR322 DNA as well as double-strand elongation in its linear form by taking advantage of a new psoralen derivative, N,N,N-trimethyl-1-(2,5,9-trimethyl-7-oxo-7Hfuro[3,2-g]chromen-3-yl) methanaminium chloride, that covalently binds to DNA through a photo-crosslinking reaction.
AB - A single-molecule strategy using atomic force microscopy has simply yet robustly probed an intercalation binding related specific structural relaxation of covalently closed circular pBR322 DNA as well as double-strand elongation in its linear form by taking advantage of a new psoralen derivative, N,N,N-trimethyl-1-(2,5,9-trimethyl-7-oxo-7Hfuro[3,2-g]chromen-3-yl) methanaminium chloride, that covalently binds to DNA through a photo-crosslinking reaction.
UR - http://www.scopus.com/inward/record.url?scp=77949520627&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77949520627&partnerID=8YFLogxK
U2 - 10.1246/bcsj.20090166
DO - 10.1246/bcsj.20090166
M3 - Article
AN - SCOPUS:77949520627
VL - 83
SP - 273
EP - 275
JO - Bulletin of the Chemical Society of Japan
JF - Bulletin of the Chemical Society of Japan
SN - 0009-2673
IS - 3
ER -