An ATP-sensitive potassium channel activator reduces infarct volume in focal cerebral ischemia in rats

Hitonori Takaba, Tetsuhiko Nagao, Hiroshi Yao, Takanari Kitazono, Setsuro Ibayashi, Masatoshi Fujishima

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Abstract

ATP-sensitive potassium channels are activated under hypoxic or ischemic conditions. The effects of ATP-sensitive potassium channel activators on cerebrovasculature and cerebral blood flow (CBF) are not well understood. We examined the effect of the ATP-sensitive potassium channel activator Y-26763 on focal cerebral ischemia in rats. In 24 spontaneously hypertensive rats, either Y-26763 (24 μg/kg) or vehicle was given by intracarotid infusion over 60 min, starting 30 min before photochemically induced thrombotic occlusion of the middle cerebral artery. CBF was measured by laser-Doppler flowmetry in the peri-ischemic penumbral cortex. Although Y-26763 lowered systemic blood pressure by 13 mmHg, the infarct volume assessed 3 days after the occlusion was significantly smaller in the Y-26763-treated group (n = 12, 71.2 ± 22.0 mm8) than in the control group (η = 12, 94.7 ± 20.4 mm3, P = 0.013). Y- 26763 did not affect CBF before or after occlusion compared with CBF values of the control group. The results are consistent with the view that the activation of the ATP-sensitive potassium channel is neuroprotective in focal cerebral ischemia.

Original languageEnglish
JournalAmerican Journal of Physiology - Regulatory Integrative and Comparative Physiology
Volume273
Issue number2 42-2
Publication statusPublished - Oct 18 1997

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Cerebrovascular Circulation
KATP Channels
Brain Ischemia
Control Groups
Laser-Doppler Flowmetry
Middle Cerebral Artery Infarction
Inbred SHR Rats
Y 26763
Blood Pressure

All Science Journal Classification (ASJC) codes

  • Physiology
  • Physiology (medical)

Cite this

An ATP-sensitive potassium channel activator reduces infarct volume in focal cerebral ischemia in rats. / Takaba, Hitonori; Nagao, Tetsuhiko; Yao, Hiroshi; Kitazono, Takanari; Ibayashi, Setsuro; Fujishima, Masatoshi.

In: American Journal of Physiology - Regulatory Integrative and Comparative Physiology, Vol. 273, No. 2 42-2, 18.10.1997.

Research output: Contribution to journalArticle

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AU - Ibayashi, Setsuro

AU - Fujishima, Masatoshi

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