An ATP-sensitive potassium channel activator reduces infarct volume in focal cerebral ischemia in rats

Hitonori Takaba, Tetsuhiko Nagao, Hiroshi Yao, Takanari Kitazono, Setsuro Ibayashi, Masatoshi Fujishima

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

ATP-sensitive potassium channels are activated under hypoxic or ischemic conditions. The effects of ATP-sensitive potassium channel activators on cerebrovasculature and cerebral blood flow (CBF) are not well understood. We examined the effect of the ATP-sensitive potassium channel activator Y-26763 on focal cerebral ischemia in rats. In 24 spontaneously hypertensive rats, either Y-26763 (24 μg/kg) or vehicle was given by intracarotid infusion over 60 min, starting 30 min before photochemically induced thrombotic occlusion of the middle cerebral artery. CBF was measured by laser-Doppler flowmetry in the peri-ischemic penumbral cortex. Although Y-26763 lowered systemic blood pressure by 13 mmHg, the infarct volume assessed 3 days after the occlusion was significantly smaller in the Y-26763-treated group (n = 12, 71.2 ± 22.0 mm8) than in the control group (η = 12, 94.7 ± 20.4 mm3, P = 0.013). Y- 26763 did not affect CBF before or after occlusion compared with CBF values of the control group. The results are consistent with the view that the activation of the ATP-sensitive potassium channel is neuroprotective in focal cerebral ischemia.

Original languageEnglish
Pages (from-to)R583-R586
JournalAmerican Journal of Physiology - Regulatory Integrative and Comparative Physiology
Volume273
Issue number2 42-2
DOIs
Publication statusPublished - 1997

All Science Journal Classification (ASJC) codes

  • Physiology
  • Physiology (medical)

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