An attempt on acceleration of peptide synthesis using the enzyme model having preorganized catalytic groups

Shigeki Sasaki, Yasutaka Takase, Kenji Koga

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

An attempt was made to accelerate intramolecular amide bond formation by introducing additional catalytic groups to the crown ether having two thiol groups as the enzyme model for the peptide synthesis. The host with methyl ester groups performed the reaction more effectively than that without them. It has been suggested that the ester groups can achieve acceleration through their preorganization in the crown host.

Original languageEnglish
Pages (from-to)6051-6054
Number of pages4
JournalTetrahedron Letters
Volume31
Issue number42
DOIs
Publication statusPublished - 1990
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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