TY - JOUR
T1 - An autopsy case of bird-related chronic hypersensitivity pneumonitis presenting with repeated acute exacerbation
AU - Mikumo, Hironori
AU - Yanagihara, Toyoshi
AU - Hamada, Naoki
AU - Hashisako, Mikiko
AU - Ijichi, Kayo
AU - Suzuki, Kunihiro
AU - Harada, Eiji
AU - Shikada, Yasunori
AU - Oda, Yoshinao
AU - Nakanishi, Yoichi
N1 - Funding Information:
The authors thank Dr. Y. Yoshizawa of Department of Integrated Pulmonology, Tokyo Medical and Dental University for his support with measurement of antibodies against pigeons and budgerigars by the ImmunoCap system in bird-related hypersensitivity pneumonitis and thank Dr. J. Fukuoka of Department of Pathology, Nagasaki University Hospital Nagasaki University Graduate School of Biomedical Sciences Nagasaki Educational and Diagnostic Center of Pathology for assistance of pathological diagnosis.
Publisher Copyright:
© 2018
PY - 2018/1/1
Y1 - 2018/1/1
N2 - A 68-year-old woman was admitted to our hospital with a dry cough in 2010. Chest computed tomography showed the appearance of a nonspecific interstitial pneumonia (NSIP) pattern. Video-assisted thoracoscopic surgery (VATS) was performed, and the specimens prominently showed a usual interstitial pneumonia (UIP) pattern. She was diagnosed with bird-related chronic hypersensitivity pneumonitis (BRCHP) on the basis of the detection of antibodies to pigeon dropping extract in her serum and a history of using feather-filled duvets and indirect exposure to birds in her living environment. Even though she was treated with corticosteroids and immunosuppressants and recommended to avoid bird-related antigens, she had a progressive course with repeated acute exacerbation episodes and died of respiratory failure. The autopsy findings showed diffuse alveolar damage superimposed on UIP. Clinicians should be aware that BRCHP patients especially with histopathologically UIP pattern may experience acute exacerbation.
AB - A 68-year-old woman was admitted to our hospital with a dry cough in 2010. Chest computed tomography showed the appearance of a nonspecific interstitial pneumonia (NSIP) pattern. Video-assisted thoracoscopic surgery (VATS) was performed, and the specimens prominently showed a usual interstitial pneumonia (UIP) pattern. She was diagnosed with bird-related chronic hypersensitivity pneumonitis (BRCHP) on the basis of the detection of antibodies to pigeon dropping extract in her serum and a history of using feather-filled duvets and indirect exposure to birds in her living environment. Even though she was treated with corticosteroids and immunosuppressants and recommended to avoid bird-related antigens, she had a progressive course with repeated acute exacerbation episodes and died of respiratory failure. The autopsy findings showed diffuse alveolar damage superimposed on UIP. Clinicians should be aware that BRCHP patients especially with histopathologically UIP pattern may experience acute exacerbation.
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U2 - 10.1016/j.rmcr.2018.04.016
DO - 10.1016/j.rmcr.2018.04.016
M3 - Article
AN - SCOPUS:85046475434
SN - 2213-0071
VL - 24
SP - 92
EP - 94
JO - Respiratory Medicine Case Reports
JF - Respiratory Medicine Case Reports
ER -