An autopsy case of idiopathic interstitial pneumonia with diffuse alveolar hemorrhage due to acute exacerbation

K. Kuwano, Satoru Fukuyama, T. Ikegami, H. Koto, N. Hagimoto, T. Matsuba, N. Fujita, N. Hara

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

There has hitherto been no report describing idiopathic interstitial pneumonia associated with diffuse alveolar hemorrhage, but we herein report one such rare case. A 75-year-old man who had received a diagnosis of idiopathic interstitial pneumonia had been followed in our hospital since 1995, and had been treated with cyclophosphamide since September 1999. He discontinued taking cyclophosphamide without informing us, and two months later he was admitted to our hospital with deterioration of dyspnea on September 13, 2000. Since chest radiography and CT findings demonstrated alveolar infiltrates in the right middle lung field, he was treated with antibiotic agents. Although no deterioration of symptoms occurred, on September 14 he began to suffer rapidly progressive dyspnea accompanied with production of bloody sputum, which eventually developed into full-blown hemoptysis in the evening of September 15. He died of respiratory failure early the next morning. The autopsy findings demonstrated diffuse alveolar hemorrhage, diffuse alveolar damage, interstitial pneumonia, and pulmonary fibrosis.

Original languageEnglish
Pages (from-to)787-791
Number of pages5
JournalNihon Kokyūki Gakkai zasshi = the journal of the Japanese Respiratory Society
Volume39
Issue number10
Publication statusPublished - Jan 1 2001

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Idiopathic Interstitial Pneumonias
Dyspnea
Cyclophosphamide
Autopsy
Hemorrhage
Hemoptysis
Pulmonary Fibrosis
Interstitial Lung Diseases
Sputum
Radiography
Respiratory Insufficiency
Thorax
Anti-Bacterial Agents
Lung

All Science Journal Classification (ASJC) codes

  • Medicine(all)

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An autopsy case of idiopathic interstitial pneumonia with diffuse alveolar hemorrhage due to acute exacerbation. / Kuwano, K.; Fukuyama, Satoru; Ikegami, T.; Koto, H.; Hagimoto, N.; Matsuba, T.; Fujita, N.; Hara, N.

In: Nihon Kokyūki Gakkai zasshi = the journal of the Japanese Respiratory Society, Vol. 39, No. 10, 01.01.2001, p. 787-791.

Research output: Contribution to journalArticle

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AU - Matsuba, T.

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AB - There has hitherto been no report describing idiopathic interstitial pneumonia associated with diffuse alveolar hemorrhage, but we herein report one such rare case. A 75-year-old man who had received a diagnosis of idiopathic interstitial pneumonia had been followed in our hospital since 1995, and had been treated with cyclophosphamide since September 1999. He discontinued taking cyclophosphamide without informing us, and two months later he was admitted to our hospital with deterioration of dyspnea on September 13, 2000. Since chest radiography and CT findings demonstrated alveolar infiltrates in the right middle lung field, he was treated with antibiotic agents. Although no deterioration of symptoms occurred, on September 14 he began to suffer rapidly progressive dyspnea accompanied with production of bloody sputum, which eventually developed into full-blown hemoptysis in the evening of September 15. He died of respiratory failure early the next morning. The autopsy findings demonstrated diffuse alveolar hemorrhage, diffuse alveolar damage, interstitial pneumonia, and pulmonary fibrosis.

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