An autopsy case of non-specific interstitial pneumonia

Taishi Harada, Takanori Akagi, Takemasa Matsumoto, Takashige Kuraki, Motokimi Shiraishi, Kentaro Watanabe, Takayuki Shirakusa, Hiroshi Iwasaki

Research output: Contribution to journalArticle

Abstract

An autopsy case of fibrotic non-specific interstitial pneumonia (NSIP) is herein reported. A 54-year-old woman was admitted to our hospital because of dry cough and fever that had continued for a month. Her chest radiograph showed diffuse reticular shadows in both lower lung fields. Analyses of bronchoalveolar lavage fluid (BALF) showed an increase in the percentage of lymphocytes and a decrease in CD4/CD8 ratio. Video-assisted thoracoscopic (VATS) lung biopsy revealed that she had fibrotic NSIP. She was treated with corticosteroid with a transient increase in vital capacity, but her condition gradually deteriorated, associated with a decrease in lymphocytes and an increase in CD4/CD8 ratio shown by repeated measurement of BALF. She died 6 years after the diagnosis. The autopsied lungs showed diffuse consolidated lesions predominantly in both lower lung fields, without honeycombing. Histologically, the lung parenchyma was diffusely involved with homogeneous fibrosis, compatible with fibrotic NSIP. However, mononuclear cell infiltration was less severe, and collagen deposition was more extensive than shown by the VATS specimen. There is a possibility that the CD4/CD8 ratio in BALF may reflect the severity of fibrosis in the lung parenchyma. Histological differences between autopsy and biopsy specimens in this case could help to elucidate the natural course of fibrotic NSIP.

Original languageEnglish
Pages (from-to)389-395
Number of pages7
JournalNihon Kokyūki Gakkai zasshi = the journal of the Japanese Respiratory Society
Volume43
Issue number7
Publication statusPublished - Jan 1 2005

Fingerprint

Interstitial Lung Diseases
Autopsy
Lung
CD4-CD8 Ratio
Bronchoalveolar Lavage Fluid
Fibrosis
Lymphocytes
Biopsy
Vital Capacity
Cough
Adrenal Cortex Hormones
Fever
Collagen
Thorax

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Harada, T., Akagi, T., Matsumoto, T., Kuraki, T., Shiraishi, M., Watanabe, K., ... Iwasaki, H. (2005). An autopsy case of non-specific interstitial pneumonia. Nihon Kokyūki Gakkai zasshi = the journal of the Japanese Respiratory Society, 43(7), 389-395.

An autopsy case of non-specific interstitial pneumonia. / Harada, Taishi; Akagi, Takanori; Matsumoto, Takemasa; Kuraki, Takashige; Shiraishi, Motokimi; Watanabe, Kentaro; Shirakusa, Takayuki; Iwasaki, Hiroshi.

In: Nihon Kokyūki Gakkai zasshi = the journal of the Japanese Respiratory Society, Vol. 43, No. 7, 01.01.2005, p. 389-395.

Research output: Contribution to journalArticle

Harada, T, Akagi, T, Matsumoto, T, Kuraki, T, Shiraishi, M, Watanabe, K, Shirakusa, T & Iwasaki, H 2005, 'An autopsy case of non-specific interstitial pneumonia', Nihon Kokyūki Gakkai zasshi = the journal of the Japanese Respiratory Society, vol. 43, no. 7, pp. 389-395.
Harada T, Akagi T, Matsumoto T, Kuraki T, Shiraishi M, Watanabe K et al. An autopsy case of non-specific interstitial pneumonia. Nihon Kokyūki Gakkai zasshi = the journal of the Japanese Respiratory Society. 2005 Jan 1;43(7):389-395.
Harada, Taishi ; Akagi, Takanori ; Matsumoto, Takemasa ; Kuraki, Takashige ; Shiraishi, Motokimi ; Watanabe, Kentaro ; Shirakusa, Takayuki ; Iwasaki, Hiroshi. / An autopsy case of non-specific interstitial pneumonia. In: Nihon Kokyūki Gakkai zasshi = the journal of the Japanese Respiratory Society. 2005 ; Vol. 43, No. 7. pp. 389-395.
@article{e0b07e6aed104fee80a65a115296e038,
title = "An autopsy case of non-specific interstitial pneumonia",
abstract = "An autopsy case of fibrotic non-specific interstitial pneumonia (NSIP) is herein reported. A 54-year-old woman was admitted to our hospital because of dry cough and fever that had continued for a month. Her chest radiograph showed diffuse reticular shadows in both lower lung fields. Analyses of bronchoalveolar lavage fluid (BALF) showed an increase in the percentage of lymphocytes and a decrease in CD4/CD8 ratio. Video-assisted thoracoscopic (VATS) lung biopsy revealed that she had fibrotic NSIP. She was treated with corticosteroid with a transient increase in vital capacity, but her condition gradually deteriorated, associated with a decrease in lymphocytes and an increase in CD4/CD8 ratio shown by repeated measurement of BALF. She died 6 years after the diagnosis. The autopsied lungs showed diffuse consolidated lesions predominantly in both lower lung fields, without honeycombing. Histologically, the lung parenchyma was diffusely involved with homogeneous fibrosis, compatible with fibrotic NSIP. However, mononuclear cell infiltration was less severe, and collagen deposition was more extensive than shown by the VATS specimen. There is a possibility that the CD4/CD8 ratio in BALF may reflect the severity of fibrosis in the lung parenchyma. Histological differences between autopsy and biopsy specimens in this case could help to elucidate the natural course of fibrotic NSIP.",
author = "Taishi Harada and Takanori Akagi and Takemasa Matsumoto and Takashige Kuraki and Motokimi Shiraishi and Kentaro Watanabe and Takayuki Shirakusa and Hiroshi Iwasaki",
year = "2005",
month = "1",
day = "1",
language = "English",
volume = "43",
pages = "389--395",
journal = "Respiratory Investigation",
issn = "2212-5345",
publisher = "Elsevier BV",
number = "7",

}

TY - JOUR

T1 - An autopsy case of non-specific interstitial pneumonia

AU - Harada, Taishi

AU - Akagi, Takanori

AU - Matsumoto, Takemasa

AU - Kuraki, Takashige

AU - Shiraishi, Motokimi

AU - Watanabe, Kentaro

AU - Shirakusa, Takayuki

AU - Iwasaki, Hiroshi

PY - 2005/1/1

Y1 - 2005/1/1

N2 - An autopsy case of fibrotic non-specific interstitial pneumonia (NSIP) is herein reported. A 54-year-old woman was admitted to our hospital because of dry cough and fever that had continued for a month. Her chest radiograph showed diffuse reticular shadows in both lower lung fields. Analyses of bronchoalveolar lavage fluid (BALF) showed an increase in the percentage of lymphocytes and a decrease in CD4/CD8 ratio. Video-assisted thoracoscopic (VATS) lung biopsy revealed that she had fibrotic NSIP. She was treated with corticosteroid with a transient increase in vital capacity, but her condition gradually deteriorated, associated with a decrease in lymphocytes and an increase in CD4/CD8 ratio shown by repeated measurement of BALF. She died 6 years after the diagnosis. The autopsied lungs showed diffuse consolidated lesions predominantly in both lower lung fields, without honeycombing. Histologically, the lung parenchyma was diffusely involved with homogeneous fibrosis, compatible with fibrotic NSIP. However, mononuclear cell infiltration was less severe, and collagen deposition was more extensive than shown by the VATS specimen. There is a possibility that the CD4/CD8 ratio in BALF may reflect the severity of fibrosis in the lung parenchyma. Histological differences between autopsy and biopsy specimens in this case could help to elucidate the natural course of fibrotic NSIP.

AB - An autopsy case of fibrotic non-specific interstitial pneumonia (NSIP) is herein reported. A 54-year-old woman was admitted to our hospital because of dry cough and fever that had continued for a month. Her chest radiograph showed diffuse reticular shadows in both lower lung fields. Analyses of bronchoalveolar lavage fluid (BALF) showed an increase in the percentage of lymphocytes and a decrease in CD4/CD8 ratio. Video-assisted thoracoscopic (VATS) lung biopsy revealed that she had fibrotic NSIP. She was treated with corticosteroid with a transient increase in vital capacity, but her condition gradually deteriorated, associated with a decrease in lymphocytes and an increase in CD4/CD8 ratio shown by repeated measurement of BALF. She died 6 years after the diagnosis. The autopsied lungs showed diffuse consolidated lesions predominantly in both lower lung fields, without honeycombing. Histologically, the lung parenchyma was diffusely involved with homogeneous fibrosis, compatible with fibrotic NSIP. However, mononuclear cell infiltration was less severe, and collagen deposition was more extensive than shown by the VATS specimen. There is a possibility that the CD4/CD8 ratio in BALF may reflect the severity of fibrosis in the lung parenchyma. Histological differences between autopsy and biopsy specimens in this case could help to elucidate the natural course of fibrotic NSIP.

UR - http://www.scopus.com/inward/record.url?scp=23844555243&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=23844555243&partnerID=8YFLogxK

M3 - Article

C2 - 16050463

AN - SCOPUS:23844555243

VL - 43

SP - 389

EP - 395

JO - Respiratory Investigation

JF - Respiratory Investigation

SN - 2212-5345

IS - 7

ER -