An autopsy case of the Marburg variant of multiple sclerosis (acute multiple sclerosis)

Makiko Suzuki, Hideya Kawasaki, Katsuhisa Masaki, Satoshi O. Suzuki, Tatsuhiro Terada, Takashi Tsuchida, Tsutomu Tokuyama, Satoshi Kono, Takashi Komori, Satoshi Baba, Jun ichi Kira, Hiroaki Miyajima

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Abstract

We herein report an autopsy case of the Marburg variant of multiple sclerosis (MS). A 29-year-old woman developed acute and progressive neurological symptoms. A diagnosis of MS was suspected based on the patient's clinical background and brain MRI findings and the lack of evidence of malignancy on a brain biopsy. Despite the administration of typical treatment for MS, a fatal outcome occurred three months after disease onset. The autopsy revealed multiple inflammatory demyelinating lesions in the central nervous system. In addition, two noteworthy histopathological features were observed compared with prototypical MS. We evaluate the pathogenic differences between the Marburg type and prototypical MS by discussing the neuropathology and cerebrospinal fluid (CSF) findings of our case.

Original languageEnglish
Pages (from-to)1825-1832
Number of pages8
JournalInternal Medicine
Volume52
Issue number16
DOIs
Publication statusPublished - Aug 21 2013

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Multiple Sclerosis
Autopsy
Fatal Outcome
Brain
Cerebrospinal Fluid
Central Nervous System
Biopsy
Neoplasms
Therapeutics

All Science Journal Classification (ASJC) codes

  • Internal Medicine

Cite this

An autopsy case of the Marburg variant of multiple sclerosis (acute multiple sclerosis). / Suzuki, Makiko; Kawasaki, Hideya; Masaki, Katsuhisa; Suzuki, Satoshi O.; Terada, Tatsuhiro; Tsuchida, Takashi; Tokuyama, Tsutomu; Kono, Satoshi; Komori, Takashi; Baba, Satoshi; Kira, Jun ichi; Miyajima, Hiroaki.

In: Internal Medicine, Vol. 52, No. 16, 21.08.2013, p. 1825-1832.

Research output: Contribution to journalArticle

Suzuki, M, Kawasaki, H, Masaki, K, Suzuki, SO, Terada, T, Tsuchida, T, Tokuyama, T, Kono, S, Komori, T, Baba, S, Kira, JI & Miyajima, H 2013, 'An autopsy case of the Marburg variant of multiple sclerosis (acute multiple sclerosis)', Internal Medicine, vol. 52, no. 16, pp. 1825-1832. https://doi.org/10.2169/internalmedicine.52.0425
Suzuki, Makiko ; Kawasaki, Hideya ; Masaki, Katsuhisa ; Suzuki, Satoshi O. ; Terada, Tatsuhiro ; Tsuchida, Takashi ; Tokuyama, Tsutomu ; Kono, Satoshi ; Komori, Takashi ; Baba, Satoshi ; Kira, Jun ichi ; Miyajima, Hiroaki. / An autopsy case of the Marburg variant of multiple sclerosis (acute multiple sclerosis). In: Internal Medicine. 2013 ; Vol. 52, No. 16. pp. 1825-1832.
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