An electrophysiological analysis of brainstem function in rats with diabetes mellitus

Deshan Liu, Wei Gao, Weiwei Lin, Toyoshi Inoguchi, Ryoichi Takayanagi

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    Abstract

    Diabetes mellitus (DM) can affect both the peripheral and the central nervous system (CNS). However, central deficits are documented less well than peripheral deficits. We believe that brainstem auditory evoked potential (BAEP) studies help in the understanding of the dysfunction of the ascending sensory pathways at various levels. Twenty-two male rats were randomly divided into two groups: normal control rats (group NC) and diabetic rats (group DM). DM was induced by a single intraperitoneal injection of 1% streptozotocin (STZ, 60 mg/kg of body weight) in all rats of DM group. After six weeks, Absolute peak latencies (PLs) of waves I, II, III, IV and V, and interpeak latencies (IPL) of I-III, III-V and I-V were measured in each rats of the experiment. Then serum insulin levels, blood biochemical indices, superoxide dismutase (SOD) and malondialdehyde (MDA) were measured. The diabetic status of the rats of DM group was kept uncontrolled throughout the study. Body weight and blood glucose of non-fasting rats (BG) in DM group were significantly altered than those of NC group (P<0.05, respectively). Neuroelectrophysiological results showed that all wave latencies and IPL I-III, I-V in DM group were prolonged at 6 weeks after induction of diabetes, and delay in waves III, V and IPL I-III, I-V was significant compared with NC group (P<0.05, respectively). It was discovered that central conduction time (CCT) of rats with diabetes had a close correlation with fasting insulin (FINS), fasting blood glucose (FBG) and MDA. These findings indicate that experimentally induced diabetes can result in a brain dysfunction as measured by the increased latencies of the IPL I-V of BAEP. In conclusion, BAEP prove to be a useful non-invasive neuroelectrophysiological technique that may help unravel both the relative involvement of the peripheral and central nervous systems in the course of diabetes mellitus, and the evolution of diabetic neuropathy.

    Original languageEnglish
    Title of host publication2011 International Conference on Remote Sensing, Environment and Transportation Engineering, RSETE 2011 - Proceedings
    Pages7372-7375
    Number of pages4
    DOIs
    Publication statusPublished - Sep 5 2011
    Event2011 International Conference on Remote Sensing, Environment and Transportation Engineering, RSETE 2011 - Nanjing, China
    Duration: Jun 24 2011Jun 26 2011

    Other

    Other2011 International Conference on Remote Sensing, Environment and Transportation Engineering, RSETE 2011
    CountryChina
    CityNanjing
    Period6/24/116/26/11

    Fingerprint

    Medical problems
    chronic illness
    Rats
    Bioelectric potentials
    Group
    Blood
    Insulin
    Neurology
    body weight
    Glucose
    deficit
    Rat control
    induction
    Brain
    brain

    All Science Journal Classification (ASJC) codes

    • Computer Networks and Communications
    • Environmental Engineering
    • Transportation

    Cite this

    Liu, D., Gao, W., Lin, W., Inoguchi, T., & Takayanagi, R. (2011). An electrophysiological analysis of brainstem function in rats with diabetes mellitus. In 2011 International Conference on Remote Sensing, Environment and Transportation Engineering, RSETE 2011 - Proceedings (pp. 7372-7375). [5966072] https://doi.org/10.1109/RSETE.2011.5966072

    An electrophysiological analysis of brainstem function in rats with diabetes mellitus. / Liu, Deshan; Gao, Wei; Lin, Weiwei; Inoguchi, Toyoshi; Takayanagi, Ryoichi.

    2011 International Conference on Remote Sensing, Environment and Transportation Engineering, RSETE 2011 - Proceedings. 2011. p. 7372-7375 5966072.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    Liu, D, Gao, W, Lin, W, Inoguchi, T & Takayanagi, R 2011, An electrophysiological analysis of brainstem function in rats with diabetes mellitus. in 2011 International Conference on Remote Sensing, Environment and Transportation Engineering, RSETE 2011 - Proceedings., 5966072, pp. 7372-7375, 2011 International Conference on Remote Sensing, Environment and Transportation Engineering, RSETE 2011, Nanjing, China, 6/24/11. https://doi.org/10.1109/RSETE.2011.5966072
    Liu D, Gao W, Lin W, Inoguchi T, Takayanagi R. An electrophysiological analysis of brainstem function in rats with diabetes mellitus. In 2011 International Conference on Remote Sensing, Environment and Transportation Engineering, RSETE 2011 - Proceedings. 2011. p. 7372-7375. 5966072 https://doi.org/10.1109/RSETE.2011.5966072
    Liu, Deshan ; Gao, Wei ; Lin, Weiwei ; Inoguchi, Toyoshi ; Takayanagi, Ryoichi. / An electrophysiological analysis of brainstem function in rats with diabetes mellitus. 2011 International Conference on Remote Sensing, Environment and Transportation Engineering, RSETE 2011 - Proceedings. 2011. pp. 7372-7375
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