An endocrine disruptor, bisphenol A, affects development in the protochordate Ciona intestinalis: Hatching rates and swimming behavior alter in a dose-dependent manner

Ayami Matsushima, Kerrianne Ryan, Yasuyuki Shimohigashi, Ian A. Meinertzhagen

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Bisphenol A (BPA) is widely used industrially to produce polycarbonate plastics and epoxy resins. Numerous studies document the harmful effects caused by low-dose BPA exposure especially on nervous systems and behavior in experimental animals such as mice and rats. Here, we exposed embryos of a model chordate, Ciona intestinalis, to seawater containing BPA to evaluate adverse effects on embryonic development and on the swimming behavior of subsequent larvae. Ciona is ideal because its larva develops rapidly and has few cells. The rate of larval hatching decreased in a dose-dependent manner with exposures to BPA above 3 μM; swimming behavior was also affected in larvae emerging from embryos exposed to 1 μM BPA. Adverse effects were most severe on fertilized eggs exposed to BPA within 7 h post-fertilization. Ciona shares twelve nuclear receptors with mammals, and BPA is proposed to disturb the physiological functions of one or more of these.

Original languageEnglish
Pages (from-to)257-263
Number of pages7
JournalEnvironmental Pollution
Volume173
DOIs
Publication statusPublished - Feb 1 2013

Fingerprint

Ciona intestinalis
Endocrine Disruptors
Mammals
Neurology
Polycarbonates
Seawater
Epoxy resins
Rats
Animals
Larva
Plastics
Embryonic Structures
Chordata
Epoxy Resins
Zygote
Cytoplasmic and Nuclear Receptors
bisphenol A
Swimming
Fertilization
Nervous System

All Science Journal Classification (ASJC) codes

  • Toxicology
  • Pollution
  • Health, Toxicology and Mutagenesis

Cite this

An endocrine disruptor, bisphenol A, affects development in the protochordate Ciona intestinalis : Hatching rates and swimming behavior alter in a dose-dependent manner. / Matsushima, Ayami; Ryan, Kerrianne; Shimohigashi, Yasuyuki; Meinertzhagen, Ian A.

In: Environmental Pollution, Vol. 173, 01.02.2013, p. 257-263.

Research output: Contribution to journalArticle

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