An enteric-coated dry emulsion formulation for oral insulin delivery

Eiichi Toorisaka, Masakazu Hashida, Noriho Kamiya, Hiroshige Ono, Yuko Kokazu, Masahiro Goto

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75 Citations (Scopus)

Abstract

A novel oral dosage formulation of insulin consisting of a surfactant, a vegetable oil, and a pH-responsive polymer has been developed. First, a solid-in-oil (S/O) suspension containing a surfactant-insulin complex was prepared. Solid-in-oil-in-water (S/O/W) emulsions were obtained by homogenizing the S/O suspension and the aqueous solution of hydroxypropylmethylcellulose phthalate (HPMCP). A microparticulate solid emulsion formulation was successfully prepared from the S/O/W emulsions by extruding them to an acidic aqueous solution, followed by lyophilization. The insulin release from the resultant dry emulsion responded to the change in external environment simulated by gastrointestinal conditions, suggesting that the new enteric-coated dry emulsion formulation is potentially applicable for the oral delivery of peptide and protein drugs.

Original languageEnglish
Pages (from-to)91-96
Number of pages6
JournalJournal of Controlled Release
Volume107
Issue number1
DOIs
Publication statusPublished - Sep 20 2005

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All Science Journal Classification (ASJC) codes

  • Pharmaceutical Science

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