TY - JOUR
T1 - An extremely rare case of small-cell lung cancer harboring variant 2 of the EML4-ALK fusion gene
AU - Toyokawa, Gouji
AU - Takenoyama, Mitsuhiro
AU - Taguchi, Kenichi
AU - Toyozawa, Ryo
AU - Inamasu, Eiko
AU - Kojo, Miyako
AU - Shiraishi, Yoshimasa
AU - Morodomi, Yosuke
AU - Takenaka, Tomoyoshi
AU - Hirai, Fumihiko
AU - Yamaguchi, Masafumi
AU - Seto, Takashi
AU - Shimokawa, Mototsugu
AU - Ichinose, Yukito
N1 - Copyright:
Copyright 2013 Elsevier B.V., All rights reserved.
PY - 2013/9
Y1 - 2013/9
N2 - Anaplastic lymphoma kinase ( ALK) fuses echinoderm microtubule-. associated protein-. like 4 ( EML4) to acquire a transforming activity in lung adenocarcinomas. However, the presence of an EML4-. ALK fusion gene in other lung cancer histologies is an extremely rare phenomenon. A 43-year-old female was referred to our department due to dyspnea on effort and left back pain. Computed tomography (CT) showed a large mass in the upper lobe of the left lung and a massive left pleural effusion, while a CT-guided needle biopsy confirmed a diagnosis of small-cell lung cancer (SCLC). Surprisingly, the tumor was genetically considered to harbor the EML4-. ALK fusion gene (variant 2). Although the patient underwent two regimens of cytotoxic chemotherapy for SCLC, she died approximately seven months after the administration of first-line chemotherapy. Our analysis of 30 consecutive patients with SCLC for EML4-. ALK revealed that two patients, including the current patient and a patient we previously reported, harbored the EML4-. ALK fusion gene.
AB - Anaplastic lymphoma kinase ( ALK) fuses echinoderm microtubule-. associated protein-. like 4 ( EML4) to acquire a transforming activity in lung adenocarcinomas. However, the presence of an EML4-. ALK fusion gene in other lung cancer histologies is an extremely rare phenomenon. A 43-year-old female was referred to our department due to dyspnea on effort and left back pain. Computed tomography (CT) showed a large mass in the upper lobe of the left lung and a massive left pleural effusion, while a CT-guided needle biopsy confirmed a diagnosis of small-cell lung cancer (SCLC). Surprisingly, the tumor was genetically considered to harbor the EML4-. ALK fusion gene (variant 2). Although the patient underwent two regimens of cytotoxic chemotherapy for SCLC, she died approximately seven months after the administration of first-line chemotherapy. Our analysis of 30 consecutive patients with SCLC for EML4-. ALK revealed that two patients, including the current patient and a patient we previously reported, harbored the EML4-. ALK fusion gene.
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U2 - 10.1016/j.lungcan.2013.05.022
DO - 10.1016/j.lungcan.2013.05.022
M3 - Article
C2 - 23787064
AN - SCOPUS:84881664426
SN - 0169-5002
VL - 81
SP - 487
EP - 490
JO - Lung Cancer
JF - Lung Cancer
IS - 3
ER -
