Genetic control of immune response in man was investigated with the system of antigen-specific T cell proliferation in vitro against streptococcal cell wall (SCW) antigen. Family analysis by Morton's maximum likelihood scoring method revealed that the low response to SCW antigen was controlled by a single dominant gene. Furthermore, this gene was shown to be closely linked to HLA (lod score was 3.209 at θ = 0). This is the first description of the HLA-linked immune suppression gene in man. The possible mechanism for this gene action was discussed.
|Number of pages||15|
|Journal||Journal of Experimental Medicine|
|Issue number||2 II|
|Publication status||Published - Dec 1 1980|
All Science Journal Classification (ASJC) codes
- Immunology and Allergy