Abstract
Genetic control of immune response in man was investigated with the system of antigen-specific T cell proliferation in vitro against streptococcal cell wall (SCW) antigen. Family analysis by Morton's maximum likelihood scoring method revealed that the low response to SCW antigen was controlled by a single dominant gene. Furthermore, this gene was shown to be closely linked to HLA (lod score was 3.209 at θ = 0). This is the first description of the HLA-linked immune suppression gene in man. The possible mechanism for this gene action was discussed.
| Original language | English |
|---|---|
| Pages (from-to) | 297-311 |
| Number of pages | 15 |
| Journal | Journal of Experimental Medicine |
| Volume | 152 |
| Issue number | 2 II |
| Publication status | Published - 1980 |
| Externally published | Yes |
All Science Journal Classification (ASJC) codes
- Immunology and Allergy
- Immunology