An HLA-linked immune suppression gene in man

T. Sasazuki, H. Kaneoka, Y. Nishimura, R. Kaneoka, M. Hayama, H. Ohkuni

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Abstract

Genetic control of immune response in man was investigated with the system of antigen-specific T cell proliferation in vitro against streptococcal cell wall (SCW) antigen. Family analysis by Morton's maximum likelihood scoring method revealed that the low response to SCW antigen was controlled by a single dominant gene. Furthermore, this gene was shown to be closely linked to HLA (lod score was 3.209 at θ = 0). This is the first description of the HLA-linked immune suppression gene in man. The possible mechanism for this gene action was discussed.

Original languageEnglish
Pages (from-to)297-311
Number of pages15
JournalJournal of Experimental Medicine
Volume152
Issue number2 II
Publication statusPublished - Dec 1 1980
Externally publishedYes

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All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

Cite this

Sasazuki, T., Kaneoka, H., Nishimura, Y., Kaneoka, R., Hayama, M., & Ohkuni, H. (1980). An HLA-linked immune suppression gene in man. Journal of Experimental Medicine, 152(2 II), 297-311.