An HLA-linked immune suppression gene in man

Takehiko Sasazuki, H. Kaneoka, Y. Nishimura, R. Kaneoka, M. Hayama, H. Ohkuni

Research output: Contribution to journalArticle

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Abstract

Genetic control of immune response in man was investigated with the system of antigen-specific T cell proliferation in vitro against streptococcal cell wall (SCW) antigen. Family analysis by Morton's maximum likelihood scoring method revealed that the low response to SCW antigen was controlled by a single dominant gene. Furthermore, this gene was shown to be closely linked to HLA (lod score was 3.209 at θ = 0). This is the first description of the HLA-linked immune suppression gene in man. The possible mechanism for this gene action was discussed.

Original languageEnglish
Pages (from-to)297-311
Number of pages15
JournalJournal of Experimental Medicine
Volume152
Issue number2 II
Publication statusPublished - Dec 1 1980

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Antigens
Cell Wall
Genes
Lod Score
Dominant Genes
Research Design
Cell Proliferation
T-Lymphocytes
In Vitro Techniques

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

Cite this

Sasazuki, T., Kaneoka, H., Nishimura, Y., Kaneoka, R., Hayama, M., & Ohkuni, H. (1980). An HLA-linked immune suppression gene in man. Journal of Experimental Medicine, 152(2 II), 297-311.

An HLA-linked immune suppression gene in man. / Sasazuki, Takehiko; Kaneoka, H.; Nishimura, Y.; Kaneoka, R.; Hayama, M.; Ohkuni, H.

In: Journal of Experimental Medicine, Vol. 152, No. 2 II, 01.12.1980, p. 297-311.

Research output: Contribution to journalArticle

Sasazuki, T, Kaneoka, H, Nishimura, Y, Kaneoka, R, Hayama, M & Ohkuni, H 1980, 'An HLA-linked immune suppression gene in man', Journal of Experimental Medicine, vol. 152, no. 2 II, pp. 297-311.
Sasazuki T, Kaneoka H, Nishimura Y, Kaneoka R, Hayama M, Ohkuni H. An HLA-linked immune suppression gene in man. Journal of Experimental Medicine. 1980 Dec 1;152(2 II):297-311.
Sasazuki, Takehiko ; Kaneoka, H. ; Nishimura, Y. ; Kaneoka, R. ; Hayama, M. ; Ohkuni, H. / An HLA-linked immune suppression gene in man. In: Journal of Experimental Medicine. 1980 ; Vol. 152, No. 2 II. pp. 297-311.
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