An improved MR sequence for attenuation correction in PET/MR hybrid imaging

Koji Sagiyama, Yuji Watanabe, Ryotaro Kamei, Daiki Shinyama, Shingo Baba, Hiroshi Honda

Research output: Contribution to journalArticle

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Abstract

The aim of this study was to investigate the effects of MR parameters on tissue segmentation and determine the optimal MR sequence for attenuation correction in PET/MR hybrid imaging. Eight healthy volunteers were examined using a PET/MR hybrid scanner with six three-dimensional turbo-field-echo sequences for attenuation correction by modifying the echo time, k-space trajectory in the phase-encoding direction, and image contrast. MR images for attenuation correction were obtained from six MR sequences in each session; each volunteer underwent four sessions. Two radiologists assessed the attenuation correction maps generated from the MR images with respect to segmentation errors and ghost artifacts on a five-point scale, and the scores were decided by consensus. Segmentation accuracy and reproducibility were compared. Multiple regression analysis was performed to determine the effects of each MR parameter. The two three-dimensional turbo-field-echo sequences with an in-phase echo time and radial k-space sampling showed the highest total scores for segmentation accuracy, with a high reproducibility. In multiple regression analysis, the score with the shortest echo time (-3.44, P < 0.0001) and Cartesian sampling in the anterior/posterior phase-encoding direction (-2.72, P = 0.002) was significantly lower than that with in-phase echo time and Cartesian sampling in the right/left phase-encoding direction. Radial k-space sampling provided a significantly higher score (+. 5.08, P < 0.0001) compared with Cartesian sampling. Furthermore, radial sampling improved intrasubject variations in the segmentation score (-8.28%, P = 0.002). Image contrast had no significant effect on the total score or reproducibility. These results suggest that three-dimensional turbo-field-echo MR sequences with an in-phase echo time and radial k-space sampling provide improved MR-based attenuation correction maps.

Original languageEnglish
Pages (from-to)345-352
Number of pages8
JournalMagnetic Resonance Imaging
Volume34
Issue number3
DOIs
Publication statusPublished - Apr 1 2016

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Multimodal Imaging
Sampling
Imaging techniques
Regression Analysis
Regression analysis
Artifacts
Volunteers
Healthy Volunteers
Trajectories
Tissue
Direction compound

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Biomedical Engineering
  • Radiology Nuclear Medicine and imaging

Cite this

An improved MR sequence for attenuation correction in PET/MR hybrid imaging. / Sagiyama, Koji; Watanabe, Yuji; Kamei, Ryotaro; Shinyama, Daiki; Baba, Shingo; Honda, Hiroshi.

In: Magnetic Resonance Imaging, Vol. 34, No. 3, 01.04.2016, p. 345-352.

Research output: Contribution to journalArticle

Sagiyama, Koji ; Watanabe, Yuji ; Kamei, Ryotaro ; Shinyama, Daiki ; Baba, Shingo ; Honda, Hiroshi. / An improved MR sequence for attenuation correction in PET/MR hybrid imaging. In: Magnetic Resonance Imaging. 2016 ; Vol. 34, No. 3. pp. 345-352.
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