An in vitro system for screening anti-hepatitis b virus drugs

Keiji Ueda, Toshiki Tsurimoto, Takemitsu Nagahata, Osamu Chisaka, Kenichi Matsubarai

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Abstract

A human hepatoblastoma cell line (HB 611) that continuously synthesizes hepatitis B viral (HBV) DNA was grown in the presence of various inhibitors of DNA synthesis, and the DNA from the cells was analyzed by the Southern blotting method to examine selective inhibition of the viral DNA synthesis. Among those that showed selective inhibition, and interferons α and β, acyclovir, and dideoxy cytidine were effective. This system should be useful for screening new antiviral agents against HBV.

Original languageEnglish
Pages (from-to)213-216
Number of pages4
JournalVirology
Volume169
Issue number1
DOIs
Publication statusPublished - Jan 1 1989
Externally publishedYes

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All Science Journal Classification (ASJC) codes

  • Virology

Cite this

Ueda, K., Tsurimoto, T., Nagahata, T., Chisaka, O., & Matsubarai, K. (1989). An in vitro system for screening anti-hepatitis b virus drugs. Virology, 169(1), 213-216. https://doi.org/10.1016/0042-6822(89)90057-3