An in vitro system for screening anti-hepatitis b virus drugs

Keiji Ueda; Toshiki Tsurimoto; Takemitsu Nagahata; Osamu Chisaka; Kenichi Matsubarai

doi:10.1016/0042-6822(89)90057-3

An in vitro system for screening anti-hepatitis b virus drugs

Keiji Ueda, Toshiki Tsurimoto, Takemitsu Nagahata, Osamu Chisaka, Kenichi Matsubarai

Research output: Contribution to journal › Article › peer-review

74 Citations (Scopus)

Abstract

A human hepatoblastoma cell line (HB 611) that continuously synthesizes hepatitis B viral (HBV) DNA was grown in the presence of various inhibitors of DNA synthesis, and the DNA from the cells was analyzed by the Southern blotting method to examine selective inhibition of the viral DNA synthesis. Among those that showed selective inhibition, and interferons α and β, acyclovir, and dideoxy cytidine were effective. This system should be useful for screening new antiviral agents against HBV.

Original language	English
Pages (from-to)	213-216
Number of pages	4
Journal	Virology
Volume	169
Issue number	1
DOIs	https://doi.org/10.1016/0042-6822(89)90057-3
Publication status	Published - Jan 1 1989
Externally published	Yes

All Science Journal Classification (ASJC) codes

Virology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/0042-6822(89)90057-3

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AU - Matsubarai, Kenichi

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AB - A human hepatoblastoma cell line (HB 611) that continuously synthesizes hepatitis B viral (HBV) DNA was grown in the presence of various inhibitors of DNA synthesis, and the DNA from the cells was analyzed by the Southern blotting method to examine selective inhibition of the viral DNA synthesis. Among those that showed selective inhibition, and interferons α and β, acyclovir, and dideoxy cytidine were effective. This system should be useful for screening new antiviral agents against HBV.

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An in vitro system for screening anti-hepatitis b virus drugs

Abstract

All Science Journal Classification (ASJC) codes

UN SDGs

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