An inadequate dose of ribavirin is related to virological relapse by chronic hepatitis C patients treated with pegylated interferon alpha-2b and ribavirin

Eiichi Ogawa, Norihiro Furusyo, Eiji Kajiwara, Kazuhiro Takahashi, Hideyuki Nomura, Yuichi Tanabe, Takeaki Satoh, Toshihiro Maruyama, Makoto Nakamuta, Kazuhiro Kotoh, Koichi Azuma, Kazufumi Dohmen, Shinji Shimoda, Jun Hayashi

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The aim of this large-scale analysis was to assess the effect of 48-week pegylated interferon (PEGIFN) a-2b and ribavirin (RBV) therapy on virological relapse by patients infected with hepatitis C virus (HCV) genotype 1. The relationship between virological relapse and the dose of PEG-IFNa-2b and RBV was investigated in 619 patients who had once cleared HCV RNA during PEGIFNa- 2b and RBV treatment for 48 weeks. The overall virological relapse rate was 34.1% (211 of 619). The relapse rate was 59.5% (22 of 37) for patients who received <6 mg/kg/day of RBV, even if a sufficient dose of PEGIFNa- 2b (C1.5 lg/kg/day) was received. In contrast, the relapse rate was 28.1% (16 of 57) for patients who received C12 mg/kg/day of RBV, irrespective of the PEG-IFNa-2b dose. The relapse rates were significantly increased with the reduction of the RBV dose for both PEG-IFNa-2b doses of C1.2 and ≥1.2 lg/kg/week (P<0.0001 and P = 0.0006, respectively). Moreover, the relapse rate was 41.2% (35 of 85) for patients with an early virological response (EVR) who received<6 mg/kg/day of RBV. The relapse rates were significantly increased with the reduction of the RBV dose in both those patients with an EVR and those with a late virological response (P = 0.0006 and P = 0.0088, respectively). To summarize, for HCV genotype 1 patients treated with PEG-IFNa-2b and RBV, the virological relapse of HCV was RBV dose-dependent, irrespective of the dose of PEG-IFNa or the effect of early viral kinetics.

Original languageEnglish
Pages (from-to)689-697
Number of pages9
JournalJournal of Infection and Chemotherapy
Issue number5
Publication statusPublished - Oct 2012


All Science Journal Classification (ASJC) codes

  • Microbiology (medical)
  • Pharmacology (medical)
  • Infectious Diseases

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