An inhibitor of lipoxygenase, nordihydroguaiaretic acid, shortens actin filaments

Masato Hirata, Tetsuaki Inamitsu, Toshihiko Hashimoto, Toshitaka Koga

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)

Abstract

An inhibitor of lipoxygenase of arachidonic acid, nordihydroguaiaretic acid, shortens actin filaments, as judged by electron microscopic observation of negatively stained actin filaments, actin sedimentability and measurement of specific viscosity, at concentrations that inhibit the migration of phagocytic cells. At higher concentrations (more than 10 μM), nordihydroguaiaretic acid strikingly inhibits myosin ATPase activity. Thus nordihydroguaiaretic acid has a severe side effect on the cytoskeleton.

Original languageEnglish
Pages (from-to)891-894
Number of pages4
JournalJournal of biochemistry
Volume95
Issue number3
DOIs
Publication statusPublished - Jan 1 1984

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology

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