TY - JOUR
T1 - An inhibitor of lipoxygenase, nordihydroguaiaretic acid, shortens actin filaments
AU - Hirata, Masato
AU - Inamitsu, Tetsuaki
AU - Hashimoto, Toshihiko
AU - Koga, Toshitaka
PY - 1984/1/1
Y1 - 1984/1/1
N2 - An inhibitor of lipoxygenase of arachidonic acid, nordihydroguaiaretic acid, shortens actin filaments, as judged by electron microscopic observation of negatively stained actin filaments, actin sedimentability and measurement of specific viscosity, at concentrations that inhibit the migration of phagocytic cells. At higher concentrations (more than 10 μM), nordihydroguaiaretic acid strikingly inhibits myosin ATPase activity. Thus nordihydroguaiaretic acid has a severe side effect on the cytoskeleton.
AB - An inhibitor of lipoxygenase of arachidonic acid, nordihydroguaiaretic acid, shortens actin filaments, as judged by electron microscopic observation of negatively stained actin filaments, actin sedimentability and measurement of specific viscosity, at concentrations that inhibit the migration of phagocytic cells. At higher concentrations (more than 10 μM), nordihydroguaiaretic acid strikingly inhibits myosin ATPase activity. Thus nordihydroguaiaretic acid has a severe side effect on the cytoskeleton.
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U2 - 10.1093/oxfordjournals.jbchem.a134683
DO - 10.1093/oxfordjournals.jbchem.a134683
M3 - Article
C2 - 6427204
AN - SCOPUS:0021401218
SN - 0021-924X
VL - 95
SP - 891
EP - 894
JO - Journal of Biochemistry
JF - Journal of Biochemistry
IS - 3
ER -