An On-Chip Vascular Network to Investigate Pericyte Migration and Intercellular Signaling

Scott Erickson; Hiroki Ihara; Sanshiro Hanada; Koichi Nishiyama; Takashi Miura; Ryuji Yokokawa

doi:10.1109/MEMS46641.2020.9056369

An On-Chip Vascular Network to Investigate Pericyte Migration and Intercellular Signaling

Scott Erickson, Hiroki Ihara, Sanshiro Hanada, Koichi Nishiyama, Takashi Miura, Ryuji Yokokawa

Bioregulation

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

Pericytes are critical support cells for vasculature. They aid in sprout formation, promote the expression of junction proteins between endothelial cells, and help regulate blood flow. But to perform these roles, they must first be recruited by endothelial cells. Here, we use a microchannel device to create self-assembling vasculature and study the effect of inhibiting pericyte-endothelial cell communication. We explore the effect of pericytes on vascular morphology and track pericyte coverage with and without the inhibitory drug, Imatinib. We find that pericyte migration and vessel morphology are changed with inhibition of platelet-derived growth factor (PDGF) receptor. In this way, we show the value of this system for both drug development and basic biological studies.

Original language	English
Title of host publication	33rd IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2020
Publisher	Institute of Electrical and Electronics Engineers Inc.
Pages	444-447
Number of pages	4
ISBN (Electronic)	9781728135809
DOIs	https://doi.org/10.1109/MEMS46641.2020.9056369
Publication status	Published - Jan 2020
Event	33rd IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2020 - Vancouver, Canada Duration: Jan 18 2020 → Jan 22 2020

Publication series

Name	Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)
Volume	2020-January
ISSN (Print)	1084-6999

Conference

Conference	33rd IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2020
Country	Canada
City	Vancouver
Period	1/18/20 → 1/22/20

All Science Journal Classification (ASJC) codes

Electronic, Optical and Magnetic Materials
Condensed Matter Physics
Mechanical Engineering
Electrical and Electronic Engineering

Access to Document

10.1109/MEMS46641.2020.9056369

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Cite this

Erickson, S., Ihara, H., Hanada, S., Nishiyama, K., Miura, T., & Yokokawa, R. (2020). An On-Chip Vascular Network to Investigate Pericyte Migration and Intercellular Signaling. In 33rd IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2020 (pp. 444-447). [9056369] (Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS); Vol. 2020-January). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/MEMS46641.2020.9056369

An On-Chip Vascular Network to Investigate Pericyte Migration and Intercellular Signaling. / Erickson, Scott; Ihara, Hiroki; Hanada, Sanshiro; Nishiyama, Koichi; Miura, Takashi; Yokokawa, Ryuji.

33rd IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2020. Institute of Electrical and Electronics Engineers Inc., 2020. p. 444-447 9056369 (Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS); Vol. 2020-January).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Erickson, S, Ihara, H, Hanada, S, Nishiyama, K, Miura, T & Yokokawa, R 2020, An On-Chip Vascular Network to Investigate Pericyte Migration and Intercellular Signaling. in 33rd IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2020., 9056369, Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS), vol. 2020-January, Institute of Electrical and Electronics Engineers Inc., pp. 444-447, 33rd IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2020, Vancouver, Canada, 1/18/20. https://doi.org/10.1109/MEMS46641.2020.9056369

Erickson S, Ihara H, Hanada S, Nishiyama K, Miura T, Yokokawa R. An On-Chip Vascular Network to Investigate Pericyte Migration and Intercellular Signaling. In 33rd IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2020. Institute of Electrical and Electronics Engineers Inc. 2020. p. 444-447. 9056369. (Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)). https://doi.org/10.1109/MEMS46641.2020.9056369

Erickson, Scott ; Ihara, Hiroki ; Hanada, Sanshiro ; Nishiyama, Koichi ; Miura, Takashi ; Yokokawa, Ryuji. / An On-Chip Vascular Network to Investigate Pericyte Migration and Intercellular Signaling. 33rd IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2020. Institute of Electrical and Electronics Engineers Inc., 2020. pp. 444-447 (Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)).

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