TY - GEN
T1 - An On-Chip Vascular Network to Investigate Pericyte Migration and Intercellular Signaling
AU - Erickson, Scott
AU - Ihara, Hiroki
AU - Hanada, Sanshiro
AU - Nishiyama, Koichi
AU - Miura, Takashi
AU - Yokokawa, Ryuji
N1 - Funding Information:
This work is supported by grants from CREST Biodynamics and the Japanese Science and Technology Agency.
Publisher Copyright:
© 2020 IEEE.
Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2020/1
Y1 - 2020/1
N2 - Pericytes are critical support cells for vasculature. They aid in sprout formation, promote the expression of junction proteins between endothelial cells, and help regulate blood flow. But to perform these roles, they must first be recruited by endothelial cells. Here, we use a microchannel device to create self-assembling vasculature and study the effect of inhibiting pericyte-endothelial cell communication. We explore the effect of pericytes on vascular morphology and track pericyte coverage with and without the inhibitory drug, Imatinib. We find that pericyte migration and vessel morphology are changed with inhibition of platelet-derived growth factor (PDGF) receptor. In this way, we show the value of this system for both drug development and basic biological studies.
AB - Pericytes are critical support cells for vasculature. They aid in sprout formation, promote the expression of junction proteins between endothelial cells, and help regulate blood flow. But to perform these roles, they must first be recruited by endothelial cells. Here, we use a microchannel device to create self-assembling vasculature and study the effect of inhibiting pericyte-endothelial cell communication. We explore the effect of pericytes on vascular morphology and track pericyte coverage with and without the inhibitory drug, Imatinib. We find that pericyte migration and vessel morphology are changed with inhibition of platelet-derived growth factor (PDGF) receptor. In this way, we show the value of this system for both drug development and basic biological studies.
UR - http://www.scopus.com/inward/record.url?scp=85083170574&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85083170574&partnerID=8YFLogxK
U2 - 10.1109/MEMS46641.2020.9056369
DO - 10.1109/MEMS46641.2020.9056369
M3 - Conference contribution
AN - SCOPUS:85083170574
T3 - Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)
SP - 444
EP - 447
BT - 33rd IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2020
PB - Institute of Electrical and Electronics Engineers Inc.
T2 - 33rd IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2020
Y2 - 18 January 2020 through 22 January 2020
ER -