An On-Chip Vascular Network to Investigate Pericyte Migration and Intercellular Signaling

Scott Erickson, Hiroki Ihara, Sanshiro Hanada, Koichi Nishiyama, Takashi Miura, Ryuji Yokokawa

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Pericytes are critical support cells for vasculature. They aid in sprout formation, promote the expression of junction proteins between endothelial cells, and help regulate blood flow. But to perform these roles, they must first be recruited by endothelial cells. Here, we use a microchannel device to create self-assembling vasculature and study the effect of inhibiting pericyte-endothelial cell communication. We explore the effect of pericytes on vascular morphology and track pericyte coverage with and without the inhibitory drug, Imatinib. We find that pericyte migration and vessel morphology are changed with inhibition of platelet-derived growth factor (PDGF) receptor. In this way, we show the value of this system for both drug development and basic biological studies.

Original languageEnglish
Title of host publication33rd IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2020
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages444-447
Number of pages4
ISBN (Electronic)9781728135809
DOIs
Publication statusPublished - Jan 2020
Event33rd IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2020 - Vancouver, Canada
Duration: Jan 18 2020Jan 22 2020

Publication series

NameProceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)
Volume2020-January
ISSN (Print)1084-6999

Conference

Conference33rd IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2020
CountryCanada
CityVancouver
Period1/18/201/22/20

All Science Journal Classification (ASJC) codes

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Mechanical Engineering
  • Electrical and Electronic Engineering

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  • Cite this

    Erickson, S., Ihara, H., Hanada, S., Nishiyama, K., Miura, T., & Yokokawa, R. (2020). An On-Chip Vascular Network to Investigate Pericyte Migration and Intercellular Signaling. In 33rd IEEE International Conference on Micro Electro Mechanical Systems, MEMS 2020 (pp. 444-447). [9056369] (Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS); Vol. 2020-January). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/MEMS46641.2020.9056369