An osteopenic/osteoporotic phenotype delays alveolar bone repair

Chih Hao Chen, Liao Wang, U. Serdar Tulu, masaki arioka, Melika Maghazeh Moghim, Benjamin Salmon, Chien Tzung Chen, Waldemar Hoffmann, Jessica Gilgenbach, John B. Brunski, Jill A. Helms

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Aging is associated with a function decline in tissue homeostasis and tissue repair. Aging is also associated with an increased incidence in osteopenia and osteoporosis, but whether these low bone mass diseases are a risk factor for delayed bone healing still remains controversial. Addressing this question is of direct clinical relevance for dental patients, since most implants are performed in older patients who are at risk of developing low bone mass conditions. The objective of this study was to assess how an osteopenic/osteoporotic phenotype affected the rate of new alveolar bone formation. Using an ovariectomized (OVX) rat model, the rates of tooth extraction socket and osteotomy healing were compared with age-matched controls. Imaging, along with molecular, cellular, and histologic analyses, demonstrated that OVX produced an overt osteoporotic phenotype in long bones, but only a subtle phenotype in alveolar bone. Nonetheless, the OVX group demonstrated significantly slower alveolar bone healing in both the extraction socket, and in the osteotomy produced in a healed extraction site. Most notably, osteotomy site preparation created a dramatically wider zone of dying and dead osteocytes in the OVX group, which was coupled with more extensive bone remodeling and a delay in the differentiation of osteoblasts. Collectively, these analyses demonstrate that the emergence of an osteoporotic phenotype delays new alveolar bone formation.

Original languageEnglish
Pages (from-to)212-219
Number of pages8
JournalBone
Volume112
DOIs
Publication statusPublished - Jul 1 2018

Fingerprint

Phenotype
Bone and Bones
Osteotomy
Osteogenesis
Tooth Socket
Osteocytes
Tooth Extraction
Bone Remodeling
Metabolic Bone Diseases
Bone Diseases
Osteoblasts
Osteoporosis
Tooth
Homeostasis
Incidence

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Physiology
  • Histology

Cite this

Chen, C. H., Wang, L., Serdar Tulu, U., arioka, M., Moghim, M. M., Salmon, B., ... Helms, J. A. (2018). An osteopenic/osteoporotic phenotype delays alveolar bone repair. Bone, 112, 212-219. https://doi.org/10.1016/j.bone.2018.04.019

An osteopenic/osteoporotic phenotype delays alveolar bone repair. / Chen, Chih Hao; Wang, Liao; Serdar Tulu, U.; arioka, masaki; Moghim, Melika Maghazeh; Salmon, Benjamin; Chen, Chien Tzung; Hoffmann, Waldemar; Gilgenbach, Jessica; Brunski, John B.; Helms, Jill A.

In: Bone, Vol. 112, 01.07.2018, p. 212-219.

Research output: Contribution to journalArticle

Chen, CH, Wang, L, Serdar Tulu, U, arioka, M, Moghim, MM, Salmon, B, Chen, CT, Hoffmann, W, Gilgenbach, J, Brunski, JB & Helms, JA 2018, 'An osteopenic/osteoporotic phenotype delays alveolar bone repair', Bone, vol. 112, pp. 212-219. https://doi.org/10.1016/j.bone.2018.04.019
Chen CH, Wang L, Serdar Tulu U, arioka M, Moghim MM, Salmon B et al. An osteopenic/osteoporotic phenotype delays alveolar bone repair. Bone. 2018 Jul 1;112:212-219. https://doi.org/10.1016/j.bone.2018.04.019
Chen, Chih Hao ; Wang, Liao ; Serdar Tulu, U. ; arioka, masaki ; Moghim, Melika Maghazeh ; Salmon, Benjamin ; Chen, Chien Tzung ; Hoffmann, Waldemar ; Gilgenbach, Jessica ; Brunski, John B. ; Helms, Jill A. / An osteopenic/osteoporotic phenotype delays alveolar bone repair. In: Bone. 2018 ; Vol. 112. pp. 212-219.
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