An overall characterization of pediatric acute lymphoblastic leukemia with CRLF2 overexpression

Mio Yano, Toshihiko Imamura, Daisuke Asai, Akiko Moriya-Saito, So Ichi Suenobu, Daiichiro Hasegawa, Takao Deguchi, Yoshiko Hashii, Hirohide Kawasaki, Hiroki Hori, Yoshiyuki Kosaka, Koji Kato, Keizo Horibe, Keiko Yumura-Yagi, Junichi Hara, Kenji Matsumoto, Nobutaka Kiyokawa, Megumi Oda, Atsushi Sato

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    Abstract

    For an overall characterization of pediatric B-cell precursor acute lymphoblastic leukemia (BCPALL) with CRLF2 overexpression (OE), we conducted genetic analysis of CRLF2 in 167 pediatric BCPALL patients. CRLF2 OE was detected in 30 (18%) of 167 patients, the P2RY8-CRLF2 fusion was identified in only 3 (1.8%) of 167 patients, all of which demonstrated CRLF2 OE. Moreover, CRLF2 gain was identified in 18 (11%) of 167 patients. Messenger RNA sequencing revealed a novel fusion transcript, CSF2RA-CRLF2, in a case with CRLF2 OE, suggesting that this fusion is associated with CRLF2 OE. In survival analysis, no significant differences in 5-year event-free survival (EFS) and overall survival were observed between patients with and without CRLF2 OE (70.7 vs. 75.4%, log rank P=0.68 and 96.4 vs. 82.1%, log rank P=0.11, respectively). However, a significant difference in 5-year EFS between CRLF2 OE patients with and without IKZF1 deletion was observed (44.4 vs. 83.1%, log rank P=0.02). In multivariate analysis, only IKZF1 deletion was a significant predictor of inferior OS (hazard ratio: 2.427, P=0.04).These findings suggest that CRLF2 OE is not an independent prognostic factor in pediatric BCPALL.

    Original languageEnglish
    Pages (from-to)815-823
    Number of pages9
    JournalGenes Chromosomes and Cancer
    Volume53
    Issue number10
    DOIs
    Publication statusPublished - Oct 2014

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    Precursor Cell Lymphoblastic Leukemia-Lymphoma
    Pediatrics
    B-Lymphoid Precursor Cells
    Disease-Free Survival
    RNA Sequence Analysis
    Survival Analysis
    Multivariate Analysis
    Messenger RNA
    Survival

    All Science Journal Classification (ASJC) codes

    • Genetics
    • Cancer Research

    Cite this

    Yano, M., Imamura, T., Asai, D., Moriya-Saito, A., Suenobu, S. I., Hasegawa, D., ... Sato, A. (2014). An overall characterization of pediatric acute lymphoblastic leukemia with CRLF2 overexpression. Genes Chromosomes and Cancer, 53(10), 815-823. https://doi.org/10.1002/gcc.22190

    An overall characterization of pediatric acute lymphoblastic leukemia with CRLF2 overexpression. / Yano, Mio; Imamura, Toshihiko; Asai, Daisuke; Moriya-Saito, Akiko; Suenobu, So Ichi; Hasegawa, Daiichiro; Deguchi, Takao; Hashii, Yoshiko; Kawasaki, Hirohide; Hori, Hiroki; Kosaka, Yoshiyuki; Kato, Koji; Horibe, Keizo; Yumura-Yagi, Keiko; Hara, Junichi; Matsumoto, Kenji; Kiyokawa, Nobutaka; Oda, Megumi; Sato, Atsushi.

    In: Genes Chromosomes and Cancer, Vol. 53, No. 10, 10.2014, p. 815-823.

    Research output: Contribution to journalArticle

    Yano, M, Imamura, T, Asai, D, Moriya-Saito, A, Suenobu, SI, Hasegawa, D, Deguchi, T, Hashii, Y, Kawasaki, H, Hori, H, Kosaka, Y, Kato, K, Horibe, K, Yumura-Yagi, K, Hara, J, Matsumoto, K, Kiyokawa, N, Oda, M & Sato, A 2014, 'An overall characterization of pediatric acute lymphoblastic leukemia with CRLF2 overexpression', Genes Chromosomes and Cancer, vol. 53, no. 10, pp. 815-823. https://doi.org/10.1002/gcc.22190
    Yano, Mio ; Imamura, Toshihiko ; Asai, Daisuke ; Moriya-Saito, Akiko ; Suenobu, So Ichi ; Hasegawa, Daiichiro ; Deguchi, Takao ; Hashii, Yoshiko ; Kawasaki, Hirohide ; Hori, Hiroki ; Kosaka, Yoshiyuki ; Kato, Koji ; Horibe, Keizo ; Yumura-Yagi, Keiko ; Hara, Junichi ; Matsumoto, Kenji ; Kiyokawa, Nobutaka ; Oda, Megumi ; Sato, Atsushi. / An overall characterization of pediatric acute lymphoblastic leukemia with CRLF2 overexpression. In: Genes Chromosomes and Cancer. 2014 ; Vol. 53, No. 10. pp. 815-823.
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    abstract = "For an overall characterization of pediatric B-cell precursor acute lymphoblastic leukemia (BCPALL) with CRLF2 overexpression (OE), we conducted genetic analysis of CRLF2 in 167 pediatric BCPALL patients. CRLF2 OE was detected in 30 (18{\%}) of 167 patients, the P2RY8-CRLF2 fusion was identified in only 3 (1.8{\%}) of 167 patients, all of which demonstrated CRLF2 OE. Moreover, CRLF2 gain was identified in 18 (11{\%}) of 167 patients. Messenger RNA sequencing revealed a novel fusion transcript, CSF2RA-CRLF2, in a case with CRLF2 OE, suggesting that this fusion is associated with CRLF2 OE. In survival analysis, no significant differences in 5-year event-free survival (EFS) and overall survival were observed between patients with and without CRLF2 OE (70.7 vs. 75.4{\%}, log rank P=0.68 and 96.4 vs. 82.1{\%}, log rank P=0.11, respectively). However, a significant difference in 5-year EFS between CRLF2 OE patients with and without IKZF1 deletion was observed (44.4 vs. 83.1{\%}, log rank P=0.02). In multivariate analysis, only IKZF1 deletion was a significant predictor of inferior OS (hazard ratio: 2.427, P=0.04).These findings suggest that CRLF2 OE is not an independent prognostic factor in pediatric BCPALL.",
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    AU - Imamura, Toshihiko

    AU - Asai, Daisuke

    AU - Moriya-Saito, Akiko

    AU - Suenobu, So Ichi

    AU - Hasegawa, Daiichiro

    AU - Deguchi, Takao

    AU - Hashii, Yoshiko

    AU - Kawasaki, Hirohide

    AU - Hori, Hiroki

    AU - Kosaka, Yoshiyuki

    AU - Kato, Koji

    AU - Horibe, Keizo

    AU - Yumura-Yagi, Keiko

    AU - Hara, Junichi

    AU - Matsumoto, Kenji

    AU - Kiyokawa, Nobutaka

    AU - Oda, Megumi

    AU - Sato, Atsushi

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