An unexpected cause of a febrile patient with huge splenomegaly

Atsushi Nonami, Hidetaka Yamamoto, Masafumi Nakamura, Koji Nagafuji, Takanori Teshima

Research output: Contribution to journalArticle

Abstract

We report an unexpected cause of a febrile patient with huge splenomegaly. A 32-year-old patient with fever and huge splenomegaly was admitted to our hospital. Diagnostic splenectomy revealed that the enlarged spleen adhered strongly to the abdominal organs. Pathologically, the splenic parenchyma showed no malignant cells, and the soft tissue adjacent to the splenic hilum showed a proliferation of fibroblastic or myofibroblastic spindle cells with fibrosis and lymphoplasmacytic infiltration. These findings lead to a diagnosis of peritoneal fibrosis, and an administration of 50 mg/day of prednisolone alleviated all the symptoms. The differential diagnosis of huge splenomegaly with fever usually includes hematolymphoid malignancies and infectious diseases; however, our case was diagnosed as idiopathic retroperitoneal fibrosis. Our case suggests that when we see patients with fever and huge splenomegaly, differential diagnosis should include retroperitoneal fibrosis.

Original languageEnglish
Pages (from-to)941-943
Number of pages3
JournalClinical Rheumatology
Volume27
Issue number7
DOIs
Publication statusPublished - Jul 1 2008

Fingerprint

Splenomegaly
Fever
Retroperitoneal Fibrosis
Differential Diagnosis
Peritoneal Fibrosis
Splenectomy
Prednisolone
Communicable Diseases
Fibrosis
Neoplasms

All Science Journal Classification (ASJC) codes

  • Rheumatology

Cite this

An unexpected cause of a febrile patient with huge splenomegaly. / Nonami, Atsushi; Yamamoto, Hidetaka; Nakamura, Masafumi; Nagafuji, Koji; Teshima, Takanori.

In: Clinical Rheumatology, Vol. 27, No. 7, 01.07.2008, p. 941-943.

Research output: Contribution to journalArticle

@article{5218b449eff54d968f9eceb1a75d98e0,
title = "An unexpected cause of a febrile patient with huge splenomegaly",
abstract = "We report an unexpected cause of a febrile patient with huge splenomegaly. A 32-year-old patient with fever and huge splenomegaly was admitted to our hospital. Diagnostic splenectomy revealed that the enlarged spleen adhered strongly to the abdominal organs. Pathologically, the splenic parenchyma showed no malignant cells, and the soft tissue adjacent to the splenic hilum showed a proliferation of fibroblastic or myofibroblastic spindle cells with fibrosis and lymphoplasmacytic infiltration. These findings lead to a diagnosis of peritoneal fibrosis, and an administration of 50 mg/day of prednisolone alleviated all the symptoms. The differential diagnosis of huge splenomegaly with fever usually includes hematolymphoid malignancies and infectious diseases; however, our case was diagnosed as idiopathic retroperitoneal fibrosis. Our case suggests that when we see patients with fever and huge splenomegaly, differential diagnosis should include retroperitoneal fibrosis.",
author = "Atsushi Nonami and Hidetaka Yamamoto and Masafumi Nakamura and Koji Nagafuji and Takanori Teshima",
year = "2008",
month = "7",
day = "1",
doi = "10.1007/s10067-008-0856-6",
language = "English",
volume = "27",
pages = "941--943",
journal = "Clinical Rheumatology",
issn = "0770-3198",
publisher = "Springer London",
number = "7",

}

TY - JOUR

T1 - An unexpected cause of a febrile patient with huge splenomegaly

AU - Nonami, Atsushi

AU - Yamamoto, Hidetaka

AU - Nakamura, Masafumi

AU - Nagafuji, Koji

AU - Teshima, Takanori

PY - 2008/7/1

Y1 - 2008/7/1

N2 - We report an unexpected cause of a febrile patient with huge splenomegaly. A 32-year-old patient with fever and huge splenomegaly was admitted to our hospital. Diagnostic splenectomy revealed that the enlarged spleen adhered strongly to the abdominal organs. Pathologically, the splenic parenchyma showed no malignant cells, and the soft tissue adjacent to the splenic hilum showed a proliferation of fibroblastic or myofibroblastic spindle cells with fibrosis and lymphoplasmacytic infiltration. These findings lead to a diagnosis of peritoneal fibrosis, and an administration of 50 mg/day of prednisolone alleviated all the symptoms. The differential diagnosis of huge splenomegaly with fever usually includes hematolymphoid malignancies and infectious diseases; however, our case was diagnosed as idiopathic retroperitoneal fibrosis. Our case suggests that when we see patients with fever and huge splenomegaly, differential diagnosis should include retroperitoneal fibrosis.

AB - We report an unexpected cause of a febrile patient with huge splenomegaly. A 32-year-old patient with fever and huge splenomegaly was admitted to our hospital. Diagnostic splenectomy revealed that the enlarged spleen adhered strongly to the abdominal organs. Pathologically, the splenic parenchyma showed no malignant cells, and the soft tissue adjacent to the splenic hilum showed a proliferation of fibroblastic or myofibroblastic spindle cells with fibrosis and lymphoplasmacytic infiltration. These findings lead to a diagnosis of peritoneal fibrosis, and an administration of 50 mg/day of prednisolone alleviated all the symptoms. The differential diagnosis of huge splenomegaly with fever usually includes hematolymphoid malignancies and infectious diseases; however, our case was diagnosed as idiopathic retroperitoneal fibrosis. Our case suggests that when we see patients with fever and huge splenomegaly, differential diagnosis should include retroperitoneal fibrosis.

UR - http://www.scopus.com/inward/record.url?scp=45049085268&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=45049085268&partnerID=8YFLogxK

U2 - 10.1007/s10067-008-0856-6

DO - 10.1007/s10067-008-0856-6

M3 - Article

C2 - 18365137

AN - SCOPUS:45049085268

VL - 27

SP - 941

EP - 943

JO - Clinical Rheumatology

JF - Clinical Rheumatology

SN - 0770-3198

IS - 7

ER -