[Analyses of plasma thrombopoietin levels in patients with thrombocytopenia].

Yasunobu Abe; Ilseung Choi; Motohiko Ikeda; Takamitsu Matsushima; Youko Suehiro; Motoaki Shiratsuchi; Naokuni Uike

[Analyses of plasma thrombopoietin levels in patients with thrombocytopenia].

Yasunobu Abe, Ilseung Choi, Motohiko Ikeda, Takamitsu Matsushima, Youko Suehiro, Motoaki Shiratsuchi, Naokuni Uike

Research output: Contribution to journal › Article › peer-review

Abstract

We measured plasma levels of thrombopoietin (TPO) in several patients with thrombocytopenia. Similar to previous reports, TPO levels in aplastic anemia (N=9) were markedly higher than those in idiopathic thrombocytopenic purpura (N=10): 16.19+/-9.07 fmol/ml and 1.21+/-1.06 fmol/ml, respectively. In patients with secondary failure of platelet recovery (N=7) as well as primary failure after hematopoietic stem cell transplantation, TPO levels were very high, reflecting impaired platelet production due to GVHD, drug treatments, and infection. When using new drugs such as TPO-receptor agonists, measurement of TPO levels might be important to differentiate the mechanism of thrombocytopenia.

Original language	English
Pages (from-to)	632-634
Number of pages	3
Journal	[Rinshō ketsueki] The Japanese journal of clinical hematology
Volume	53
Issue number	6
Publication status	Published - Jun 2012

All Science Journal Classification (ASJC) codes

Medicine(all)

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[Analyses of plasma thrombopoietin levels in patients with thrombocytopenia]. / Abe, Yasunobu; Choi, Ilseung; Ikeda, Motohiko; Matsushima, Takamitsu; Suehiro, Youko; Shiratsuchi, Motoaki; Uike, Naokuni.

In: [Rinshō ketsueki] The Japanese journal of clinical hematology, Vol. 53, No. 6, 06.2012, p. 632-634.

Research output: Contribution to journal › Article › peer-review

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AU - Abe, Yasunobu

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AU - Suehiro, Youko

AU - Shiratsuchi, Motoaki

AU - Uike, Naokuni

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AB - We measured plasma levels of thrombopoietin (TPO) in several patients with thrombocytopenia. Similar to previous reports, TPO levels in aplastic anemia (N=9) were markedly higher than those in idiopathic thrombocytopenic purpura (N=10): 16.19+/-9.07 fmol/ml and 1.21+/-1.06 fmol/ml, respectively. In patients with secondary failure of platelet recovery (N=7) as well as primary failure after hematopoietic stem cell transplantation, TPO levels were very high, reflecting impaired platelet production due to GVHD, drug treatments, and infection. When using new drugs such as TPO-receptor agonists, measurement of TPO levels might be important to differentiate the mechanism of thrombocytopenia.

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[Analyses of plasma thrombopoietin levels in patients with thrombocytopenia].

Abstract

All Science Journal Classification (ASJC) codes

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