Abstract
We measured plasma levels of thrombopoietin (TPO) in several patients with thrombocytopenia. Similar to previous reports, TPO levels in aplastic anemia (N=9) were markedly higher than those in idiopathic thrombocytopenic purpura (N=10): 16.19+/-9.07 fmol/ml and 1.21+/-1.06 fmol/ml, respectively. In patients with secondary failure of platelet recovery (N=7) as well as primary failure after hematopoietic stem cell transplantation, TPO levels were very high, reflecting impaired platelet production due to GVHD, drug treatments, and infection. When using new drugs such as TPO-receptor agonists, measurement of TPO levels might be important to differentiate the mechanism of thrombocytopenia.
| Original language | English |
|---|---|
| Pages (from-to) | 632-634 |
| Number of pages | 3 |
| Journal | [Rinshō ketsueki] The Japanese journal of clinical hematology |
| Volume | 53 |
| Issue number | 6 |
| Publication status | Published - Jun 2012 |
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All Science Journal Classification (ASJC) codes
- Medicine(all)
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[Analyses of plasma thrombopoietin levels in patients with thrombocytopenia]. / Abe, Yasunobu; Choi, Ilseung; Ikeda, Motohiko; Matsushima, Takamitsu; Suehiro, Youko; Shiratsuchi, Motoaki; Uike, Naokuni.
In: [Rinshō ketsueki] The Japanese journal of clinical hematology, Vol. 53, No. 6, 06.2012, p. 632-634.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - [Analyses of plasma thrombopoietin levels in patients with thrombocytopenia].
AU - Abe, Yasunobu
AU - Choi, Ilseung
AU - Ikeda, Motohiko
AU - Matsushima, Takamitsu
AU - Suehiro, Youko
AU - Shiratsuchi, Motoaki
AU - Uike, Naokuni
PY - 2012/6
Y1 - 2012/6
N2 - We measured plasma levels of thrombopoietin (TPO) in several patients with thrombocytopenia. Similar to previous reports, TPO levels in aplastic anemia (N=9) were markedly higher than those in idiopathic thrombocytopenic purpura (N=10): 16.19+/-9.07 fmol/ml and 1.21+/-1.06 fmol/ml, respectively. In patients with secondary failure of platelet recovery (N=7) as well as primary failure after hematopoietic stem cell transplantation, TPO levels were very high, reflecting impaired platelet production due to GVHD, drug treatments, and infection. When using new drugs such as TPO-receptor agonists, measurement of TPO levels might be important to differentiate the mechanism of thrombocytopenia.
AB - We measured plasma levels of thrombopoietin (TPO) in several patients with thrombocytopenia. Similar to previous reports, TPO levels in aplastic anemia (N=9) were markedly higher than those in idiopathic thrombocytopenic purpura (N=10): 16.19+/-9.07 fmol/ml and 1.21+/-1.06 fmol/ml, respectively. In patients with secondary failure of platelet recovery (N=7) as well as primary failure after hematopoietic stem cell transplantation, TPO levels were very high, reflecting impaired platelet production due to GVHD, drug treatments, and infection. When using new drugs such as TPO-receptor agonists, measurement of TPO levels might be important to differentiate the mechanism of thrombocytopenia.
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UR - http://www.scopus.com/inward/citedby.url?scp=84867294369&partnerID=8YFLogxK
M3 - Article
C2 - 22790640
AN - SCOPUS:84867294369
VL - 53
SP - 632
EP - 634
JO - [Rinsho ketsueki] The Japanese journal of clinical hematology
JF - [Rinsho ketsueki] The Japanese journal of clinical hematology
SN - 0485-1439
IS - 6
ER -