Analysis for effect of cell shape on hippo signaling pathway using micro-fabricated cell culture platform

Ken Ichi Wada, Kazuyoshi Itoga, Teruo Okano, Shigenobu Yonemura, Hiroshi Sasaki

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Cell density affects Hippo signals, which regulates cell proliferation, but its molecular mechanism is still unclear. In this study, we examined the effect of cell shape on Hippo pathway by using micro fabricated cell culture platform and found that F-actin formation was modulated by cell shapes and F-actin had an inhibitory effect on Hippo pathway. This findings suggest that cell shape is an important factor in the regulation of cell proliferation via Hippo signaling, and that cells can detect density through their resulting morphology by F-actin mediated mechanism to regulate proliferation.

Original languageEnglish
Title of host publicationProceedings of the 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012
PublisherChemical and Biological Microsystems Society
Pages1051-1053
Number of pages3
ISBN (Print)9780979806452
Publication statusPublished - 2012
Externally publishedYes
Event16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012 - Okinawa, Japan
Duration: Oct 28 2012Nov 1 2012

Publication series

NameProceedings of the 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012

Other

Other16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012
CountryJapan
CityOkinawa
Period10/28/1211/1/12

All Science Journal Classification (ASJC) codes

  • Chemical Engineering (miscellaneous)
  • Bioengineering

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