Analysis of adverse events of bevacizumab-containing systemic chemotherapy for metastatic colorectal cancer in Japan

Taichi Isobe, Keita Uchino, Chinatsu Makiyama, Hiroshi Ariyama, Shuji Arita, Shingo Tamura, Masato Komoda, Hitoshi Kusaba, Tsuyoshi Shirakawa, Taito Esaki, Kenji Mitsugi, Shigeo Takaishi, Koichi Akashi, Eishi Baba

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Abstract

Background: Bevacizumab (BV) is widely used in chemotherapy for metastatic colorectal cancer (mCRC). Although specific adverse events have been observed, their risk factors have not been clarified. Patients and Methods: 178 mCRC patients who underwent chemotherapy were retrospectively examined and correlations between possible risk factors and adverse events were analyzed. Results: 87 out of 178 patients were treated with BV-containing chemotherapy. Possible risk factors for BV-related adverse events were: remaining primary tumor, current bleeding, history of arterial thromboembolism (ATE), hypertension, and proteinuria, and these were observed in 22%, 2%, 7%, 16%, and 8% of patients, respectively. Patients with hypertension prior to chemotherapy developed significantly worse hypertension (p=0.018). Gastrointestinal bleeding occurred in 3 out of 18 patients with residual primary tumor (16.7%) and 6 out of 63 patients with no primary tumor (8.7%) (p=0.385). Conclusion: Pre-existing hypertension appears to be a risk factor for BV-related deterioration of hypertension.

Original languageEnglish
Pages (from-to)2035-2040
Number of pages6
JournalAnticancer research
Volume34
Issue number4
Publication statusPublished - Apr 1 2014

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Colorectal Neoplasms
Japan
Drug Therapy
Hypertension
Prehypertension
Hemorrhage
Thromboembolism
Residual Neoplasm
Bevacizumab
Proteinuria
Neoplasms

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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Analysis of adverse events of bevacizumab-containing systemic chemotherapy for metastatic colorectal cancer in Japan. / Isobe, Taichi; Uchino, Keita; Makiyama, Chinatsu; Ariyama, Hiroshi; Arita, Shuji; Tamura, Shingo; Komoda, Masato; Kusaba, Hitoshi; Shirakawa, Tsuyoshi; Esaki, Taito; Mitsugi, Kenji; Takaishi, Shigeo; Akashi, Koichi; Baba, Eishi.

In: Anticancer research, Vol. 34, No. 4, 01.04.2014, p. 2035-2040.

Research output: Contribution to journalArticle

Isobe, T, Uchino, K, Makiyama, C, Ariyama, H, Arita, S, Tamura, S, Komoda, M, Kusaba, H, Shirakawa, T, Esaki, T, Mitsugi, K, Takaishi, S, Akashi, K & Baba, E 2014, 'Analysis of adverse events of bevacizumab-containing systemic chemotherapy for metastatic colorectal cancer in Japan', Anticancer research, vol. 34, no. 4, pp. 2035-2040.
Isobe, Taichi ; Uchino, Keita ; Makiyama, Chinatsu ; Ariyama, Hiroshi ; Arita, Shuji ; Tamura, Shingo ; Komoda, Masato ; Kusaba, Hitoshi ; Shirakawa, Tsuyoshi ; Esaki, Taito ; Mitsugi, Kenji ; Takaishi, Shigeo ; Akashi, Koichi ; Baba, Eishi. / Analysis of adverse events of bevacizumab-containing systemic chemotherapy for metastatic colorectal cancer in Japan. In: Anticancer research. 2014 ; Vol. 34, No. 4. pp. 2035-2040.
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AU - Isobe, Taichi

AU - Uchino, Keita

AU - Makiyama, Chinatsu

AU - Ariyama, Hiroshi

AU - Arita, Shuji

AU - Tamura, Shingo

AU - Komoda, Masato

AU - Kusaba, Hitoshi

AU - Shirakawa, Tsuyoshi

AU - Esaki, Taito

AU - Mitsugi, Kenji

AU - Takaishi, Shigeo

AU - Akashi, Koichi

AU - Baba, Eishi

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N2 - Background: Bevacizumab (BV) is widely used in chemotherapy for metastatic colorectal cancer (mCRC). Although specific adverse events have been observed, their risk factors have not been clarified. Patients and Methods: 178 mCRC patients who underwent chemotherapy were retrospectively examined and correlations between possible risk factors and adverse events were analyzed. Results: 87 out of 178 patients were treated with BV-containing chemotherapy. Possible risk factors for BV-related adverse events were: remaining primary tumor, current bleeding, history of arterial thromboembolism (ATE), hypertension, and proteinuria, and these were observed in 22%, 2%, 7%, 16%, and 8% of patients, respectively. Patients with hypertension prior to chemotherapy developed significantly worse hypertension (p=0.018). Gastrointestinal bleeding occurred in 3 out of 18 patients with residual primary tumor (16.7%) and 6 out of 63 patients with no primary tumor (8.7%) (p=0.385). Conclusion: Pre-existing hypertension appears to be a risk factor for BV-related deterioration of hypertension.

AB - Background: Bevacizumab (BV) is widely used in chemotherapy for metastatic colorectal cancer (mCRC). Although specific adverse events have been observed, their risk factors have not been clarified. Patients and Methods: 178 mCRC patients who underwent chemotherapy were retrospectively examined and correlations between possible risk factors and adverse events were analyzed. Results: 87 out of 178 patients were treated with BV-containing chemotherapy. Possible risk factors for BV-related adverse events were: remaining primary tumor, current bleeding, history of arterial thromboembolism (ATE), hypertension, and proteinuria, and these were observed in 22%, 2%, 7%, 16%, and 8% of patients, respectively. Patients with hypertension prior to chemotherapy developed significantly worse hypertension (p=0.018). Gastrointestinal bleeding occurred in 3 out of 18 patients with residual primary tumor (16.7%) and 6 out of 63 patients with no primary tumor (8.7%) (p=0.385). Conclusion: Pre-existing hypertension appears to be a risk factor for BV-related deterioration of hypertension.

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