Analysis of cationic comb-type copolymers/DNA interaction by the single molecular observation and intermolecular force measurement.

Masanori Hirano, Naohiko Shimada, Arihiro Kano, Satoru Kidoaki, Atsushi Maruyama

Research output: Contribution to journalArticle

Abstract

We have reported that poly(L-lysine)-graft-dextran (PLL-g-Dex) accelerates DNA hybridization and increases stability of a double stranded DNA (dsDNA). Furthermore, PLL-g-Dex was found to stimulate the DNA strand exchange reaction between dsDNA and its complementary single stranded DNA (ssDNA). In order to better understand these phenomena, we evaluate PLL-g-Dex/DNA interaction by the single molecular observation and intermolecular force measurement at single molecular level. We have been able to observe PLL-g-Dex/DNA complex at single molecular level. PLL-g-Dex was found to increases the dissociation force of a dsDNA.

Original languageEnglish
Pages (from-to)715-716
Number of pages2
JournalNucleic acids symposium series (2004)
Issue number52
Publication statusPublished - Dec 1 2008

All Science Journal Classification (ASJC) codes

  • Medicine(all)

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