TY - JOUR
T1 - Analysis of cellular signal transduction from an information theoretic approach
AU - Uda, Shinsuke
AU - Kuroda, Shinya
N1 - Funding Information:
We thank our laboratory members for critical reading of the manuscript. This work was supported by the Creation of Fundamental Technologies for Understanding and Control of Biosystem Dynamics, CREST , from the Japan Science and Technology ( JST ); by a KAKENHI Young Scientists (B) (# 25830142 ) from the Ministry of Education, Culture, Sports, Science and Technology of Japan ( MEXT ), and by a Human Frontier Science Project ( HFSP ) grant ( RGP0061/2011 ).
Publisher Copyright:
© 2015 Elsevier Ltd.
PY - 2016/3/1
Y1 - 2016/3/1
N2 - Signal transduction processes the information of various cellular functions, including cell proliferation, differentiation, and death. The information for controlling cell fate is transmitted by concentrations of cellular signaling molecules. However, how much information is transmitted in signaling pathways has thus far not been investigated. Shannon's information theory paves the way to quantitatively analyze information transmission in signaling pathways. The theory has recently been applied to signal transduction, and mutual information of signal transduction has been determined to be a measure of information transmission. We review this work and provide an overview of how signal transduction transmits informational input and exerts biological output.
AB - Signal transduction processes the information of various cellular functions, including cell proliferation, differentiation, and death. The information for controlling cell fate is transmitted by concentrations of cellular signaling molecules. However, how much information is transmitted in signaling pathways has thus far not been investigated. Shannon's information theory paves the way to quantitatively analyze information transmission in signaling pathways. The theory has recently been applied to signal transduction, and mutual information of signal transduction has been determined to be a measure of information transmission. We review this work and provide an overview of how signal transduction transmits informational input and exerts biological output.
UR - http://www.scopus.com/inward/record.url?scp=84960317598&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84960317598&partnerID=8YFLogxK
U2 - 10.1016/j.semcdb.2015.12.011
DO - 10.1016/j.semcdb.2015.12.011
M3 - Review article
C2 - 26710655
AN - SCOPUS:84960317598
SN - 1084-9521
VL - 51
SP - 24
EP - 31
JO - Seminars in Cell Biology
JF - Seminars in Cell Biology
ER -