Analysis of gastric cancer with cDNA microarray

Naotsugu Haraguchi; Hiroshi Inoue; Koshi Mimori; Fumiaki Tanaka; Tohru Utsunomiya; Kouji Yoshikawa; Masaki Mori

doi:10.1007/s00280-004-0882-2

Analysis of gastric cancer with cDNA microarray

Naotsugu Haraguchi, Hiroshi Inoue, Koshi Mimori, Fumiaki Tanaka, Tohru Utsunomiya, Kouji Yoshikawa, Masaki Mori

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

Abstract

Recent advances in cDNA microarray techniques have enabled us to study the expression of many genes simultaneously. As gastric cancer remains one of the most common cancers in Japan, we studied gene expression profiles in gastric cancer by cDNA microarray analysis to determine if it would be clinically useful. We demonstrated two points. First, cDNA microarray might be useful as a prognostic indicator. However, there remain several important problems to be solved and these are discussed. Second, laser microdissection plus cDNA microarray might be useful in determining the specific genes that correlate to cancer metastasis or histological subtype. We review the pros and cons for cDNA microarray analysis in the context of gastric cancer.

Original language	English
Pages (from-to)	S21-S24
Journal	Cancer chemotherapy and pharmacology
Volume	54
Issue number	SUPPL. 1
DOIs	https://doi.org/10.1007/s00280-004-0882-2
Publication status	Published - Sep 2004

All Science Journal Classification (ASJC) codes

Oncology
Toxicology
Pharmacology
Cancer Research
Pharmacology (medical)

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AU - Haraguchi, Naotsugu

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AU - Utsunomiya, Tohru

AU - Yoshikawa, Kouji

AU - Mori, Masaki

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AB - Recent advances in cDNA microarray techniques have enabled us to study the expression of many genes simultaneously. As gastric cancer remains one of the most common cancers in Japan, we studied gene expression profiles in gastric cancer by cDNA microarray analysis to determine if it would be clinically useful. We demonstrated two points. First, cDNA microarray might be useful as a prognostic indicator. However, there remain several important problems to be solved and these are discussed. Second, laser microdissection plus cDNA microarray might be useful in determining the specific genes that correlate to cancer metastasis or histological subtype. We review the pros and cons for cDNA microarray analysis in the context of gastric cancer.

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Analysis of gastric cancer with cDNA microarray

Abstract

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