Analysis of GNA13 Protein in Follicular Lymphoma and its Association with Poor Prognosis

Joji Shimono, Hiroaki Miyoshi, Noriaki Yoshida, Takeharu Kato, Kensaku Sato, Takeshi Sugio, Kohta Miyawaki, Daisuke Kurita, Yuya Sasaki, Keisuke Kawamoto, Yoshitaka Imaizumi, Koji Kato, Koji Nagafuji, Koichi Akashi, Masao Seto, Takanori Teshima, Koichi Ohshima

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

GNA13 is a G protein involved in modulating tumor proliferative capacity, infiltration, metastasis, and migration. Genomic alteration of GNA13 was frequently observed in follicular lymphoma (FL). In this study, we examined 167 cases of FL by immunostaining of GNA13 using tissue microarray to evaluate the clinical significance. There were 26 GNA13-positive cases (15.6%) and 141 GNA13-negative cases (84.4%). GNA13-positive cases had a higher incidence of early progression of disease for which disease progression was recognized within 2 years compared with GNA13-negative cases (P=0.03). There were no significant differences in other clinicopathologic factors including histological grade, BCL2-IGH translocation, immunohistochemical phenotype, and Follicular Lymphoma International Prognostic Index. In addition, overall survival and progression-free survival were poorer in GNA13-positive cases than in GNA13-negative cases (P=0.009 and 0.005, respectively). In multivariate analysis, GNA13 positivity was found to be a poor prognostic factor for overall survival and progression-free survival. Thus, GNA13 protein expression was an independent prognostic factor and may affect disease progression in FL.

Original languageEnglish
Pages (from-to)1466-1471
Number of pages6
JournalAmerican Journal of Surgical Pathology
Volume42
Issue number11
DOIs
Publication statusPublished - Nov 1 2018

All Science Journal Classification (ASJC) codes

  • Anatomy
  • Surgery
  • Pathology and Forensic Medicine

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