Analysis of Stereochemical Stability of Dynamic Chiral Molecules Using an Automated Microflow Measurement System

Research output: Contribution to journalArticlepeer-review

Abstract

An automated microflow measurement system for the kinetic study of racemization of dynamic chiral molecules was developed. This system facilitated the analysis of fast racemization within several seconds at elevated temperatures owing to its rapid heating ability, high performance for controlling short residence times, and ease of connection to HPLC systems for direct measurement of the enantiomeric purity. A more precise analysis was realized by combination of microflow and common batch measurements over a broad range of temperatures.

Original languageEnglish
Pages (from-to)9651-9657
Number of pages7
JournalJournal of Organic Chemistry
Volume86
Issue number14
DOIs
Publication statusPublished - Jul 16 2021

All Science Journal Classification (ASJC) codes

  • Organic Chemistry

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