Abstract
Nucleoside-phospholipid conjugates containing a nucleotidyl residue and two long alkyl chains have been synthesized and their self-organization and morphology have been investigated. In particular, 5'-phosphatidylcytidine spontaneously assembled to form linear and circular strands. Image processing analysis of the electron micrograph of the strands confirmed that they are indeed double helix reminiscent of the double-helical structure of nucleic acids. The linear and circular strands from 5'-phosphatidylcytidine had grooves of approximately 100 A in diameter and right-handed helical pitch of approximately 240 A.
Original language | English |
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Pages (from-to) | 189-192 |
Number of pages | 4 |
Journal | Nucleic acids symposium series |
Issue number | 19 |
Publication status | Published - 1988 |
Externally published | Yes |
All Science Journal Classification (ASJC) codes
- Medicine(all)