Abstract
Nucleoside-phospholipid conjugates containing a nucleotidyl residue and two long alkyl chains have been synthesized and their self-organization and morphology have been investigated. In particular, 5'-phosphatidylcytidine spontaneously assembled to form linear and circular strands. Image processing analysis of the electron micrograph of the strands confirmed that they are indeed double helix reminiscent of the double-helical structure of nucleic acids. The linear and circular strands from 5'-phosphatidylcytidine had grooves of approximately 100 A in diameter and right-handed helical pitch of approximately 240 A.
| Original language | English |
|---|---|
| Pages (from-to) | 189-192 |
| Number of pages | 4 |
| Journal | Nucleic acids symposium series |
| Issue number | 19 |
| Publication status | Published - Jan 1 1988 |
| Externally published | Yes |
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All Science Journal Classification (ASJC) codes
- Medicine(all)
Cite this
Analysis of superhelical structures of nucleic acid-lipid conjugates by image processing. / Yanagawa, H.; Ogawa, Y.; Furuta, Hiroyuki; Tsuno, K.
In: Nucleic acids symposium series, No. 19, 01.01.1988, p. 189-192.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Analysis of superhelical structures of nucleic acid-lipid conjugates by image processing.
AU - Yanagawa, H.
AU - Ogawa, Y.
AU - Furuta, Hiroyuki
AU - Tsuno, K.
PY - 1988/1/1
Y1 - 1988/1/1
N2 - Nucleoside-phospholipid conjugates containing a nucleotidyl residue and two long alkyl chains have been synthesized and their self-organization and morphology have been investigated. In particular, 5'-phosphatidylcytidine spontaneously assembled to form linear and circular strands. Image processing analysis of the electron micrograph of the strands confirmed that they are indeed double helix reminiscent of the double-helical structure of nucleic acids. The linear and circular strands from 5'-phosphatidylcytidine had grooves of approximately 100 A in diameter and right-handed helical pitch of approximately 240 A.
AB - Nucleoside-phospholipid conjugates containing a nucleotidyl residue and two long alkyl chains have been synthesized and their self-organization and morphology have been investigated. In particular, 5'-phosphatidylcytidine spontaneously assembled to form linear and circular strands. Image processing analysis of the electron micrograph of the strands confirmed that they are indeed double helix reminiscent of the double-helical structure of nucleic acids. The linear and circular strands from 5'-phosphatidylcytidine had grooves of approximately 100 A in diameter and right-handed helical pitch of approximately 240 A.
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UR - http://www.scopus.com/inward/citedby.url?scp=0024265922&partnerID=8YFLogxK
M3 - Article
C2 - 3226916
AN - SCOPUS:0024265922
SP - 189
EP - 192
JO - Nucleic acids symposium series
JF - Nucleic acids symposium series
SN - 0261-3166
IS - 19
ER -