Abstract
Nucleoside-phospholipid conjugates containing a nucleotidyl residue and two long alkyl chains have been synthesized and their self-organization and morphology have been investigated. In particular, 5'-phosphatidylcytidine spontaneously assembled to form linear and circular strands. Image processing analysis of the electron micrograph of the strands confirmed that they are indeed double helix reminiscent of the double-helical structure of nucleic acids. The linear and circular strands from 5'-phosphatidylcytidine had grooves of approximately 100 A in diameter and right-handed helical pitch of approximately 240 A.
| Original language | English |
|---|---|
| Pages (from-to) | 189-192 |
| Number of pages | 4 |
| Journal | Nucleic acids symposium series |
| Issue number | 19 |
| Publication status | Published - 1988 |
| Externally published | Yes |
All Science Journal Classification (ASJC) codes
- Medicine(all)
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Yanagawa, H., Ogawa, Y., Furuta, H., & Tsuno, K. (1988). Analysis of superhelical structures of nucleic acid-lipid conjugates by image processing. Nucleic acids symposium series, (19), 189-192.