Analysis of superhelical structures of nucleic acid-lipid conjugates by image processing.

H. Yanagawa, Y. Ogawa, H. Furuta, K. Tsuno

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Nucleoside-phospholipid conjugates containing a nucleotidyl residue and two long alkyl chains have been synthesized and their self-organization and morphology have been investigated. In particular, 5'-phosphatidylcytidine spontaneously assembled to form linear and circular strands. Image processing analysis of the electron micrograph of the strands confirmed that they are indeed double helix reminiscent of the double-helical structure of nucleic acids. The linear and circular strands from 5'-phosphatidylcytidine had grooves of approximately 100 A in diameter and right-handed helical pitch of approximately 240 A.

Original languageEnglish
Pages (from-to)189-192
Number of pages4
JournalNucleic acids symposium series
Issue number19
Publication statusPublished - 1988
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Medicine(all)

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